Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers

Journal of the American Chemical Society

Volumn 128, Issue 37, 2006, Pages 12162-12168

  Sasaki, Shunta ^a   Bando, Toshikazu ^a   Minoshima, Masafumi ^a   Shimizu, Tatsuhiko ^a   Shinohara, Ken Ichi ^a   Takaoka, Toshiyasu ^a   Sugiyama, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINES; CHEMICAL BONDS; ELECTROPHORESIS; GELS; HUMAN ENGINEERING; SYNTHESIS (CHEMICAL);

CYTOTOXICITIES; INDOLE LINKERS; PYRROLES; TELOMERES;

COPOLYMERS;

1 (CHLOROMETHYL) 5 HYDROXY 1,2 DIHYDRO 3H BENZ[E]INDOLE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONJUGATION; CONTROLLED STUDY; DNA ALKYLATION; DNA DENATURATION; DNA SEQUENCE; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; POLYACRYLAMIDE GEL ELECTROPHORESIS; SYNTHESIS; TELOMERE;

ALKYLATION; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INDOLES; MOLECULAR SEQUENCE DATA; NEOPLASMS; PYRROLES; REPETITIVE SEQUENCES, NUCLEIC ACID; SUBSTRATE SPECIFICITY; TELOMERE;

EID: 33748792040     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0626584     Document Type: Article

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