메뉴 건너뛰기




Volumn 231, Issue 18, 2014, Pages 3707-3718

Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD)

Author keywords

Compulsive checking behavior; Dopamine serotonin interaction; mCPP; Quinpirole; Security motivation

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; QUINPIROLE; 1-(3-CHLOROPHENYL)PIPERAZINE; DOPAMINE 3 RECEPTOR; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST;

EID: 84906936535     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3505-6     Document Type: Article
Times cited : (19)

References (96)
  • 1
    • 84893048020 scopus 로고    scopus 로고
    • Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy
    • Albert PR, Le François B (2010) Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy. Front Neurosci 4:35
    • (2010) Front Neurosci , vol.4 , pp. 35
    • Albert, P.R.1    Le François, B.2
  • 2
    • 33846426067 scopus 로고    scopus 로고
    • Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
    • DOI 10.1016/j.pharmthera.2006.08.004, PII S0163725806001525
    • Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296-320 (Pubitemid 46149046)
    • (2007) Pharmacology and Therapeutics , vol.113 , Issue.2 , pp. 296-320
    • Alex, K.D.1    Pehek, E.A.2
  • 3
    • 84872075489 scopus 로고    scopus 로고
    • Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit
    • Alkhatib AH, Dvorkin-Gheva A, Szechtman H (2013) Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit. Behav Pharmacol 24:65-73
    • (2013) Behav Pharmacol , vol.24 , pp. 65-73
    • Alkhatib, A.H.1    Dvorkin-Gheva, A.2    Szechtman, H.3
  • 4
    • 51249109478 scopus 로고    scopus 로고
    • Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia
    • Amato D, Stasi MA, Borsini F, Nencini P (2008) Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia. Psychopharmacol (Berl) 200:157-165
    • (2008) Psychopharmacol (Berl) , vol.200 , pp. 157-165
    • Amato, D.1    Stasi, M.A.2    Borsini, F.3    Nencini, P.4
  • 5
    • 77957342017 scopus 로고    scopus 로고
    • A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals
    • Andersen SL, Greene-Colozzi EA, Sonntag KC (2010) A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals. Biol Psychiatry 68:741-747
    • (2010) Biol Psychiatry , vol.68 , pp. 741-747
    • Andersen, S.L.1    Greene-Colozzi, E.A.2    Sonntag, K.C.3
  • 6
    • 2342537848 scopus 로고    scopus 로고
    • Pathophysiology of obsessive-compulsive disorder: A necessary link between phenomenology, neuropsychology, imagery and physiology
    • DOI 10.1016/j.pneurobio.2004.02.004, PII S0301008204000280
    • Aouizerate B, Guehl D, Cuny E, Rougier A, Bioulac B, Tignol J, Burbaud P (2004) Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Prog Neurobiol 72:195-221 (Pubitemid 38591296)
    • (2004) Progress in Neurobiology , vol.72 , Issue.3 , pp. 195-221
    • Aouizerate, B.1    Guehl, D.2    Cuny, E.3    Rougier, A.4    Bioulac, B.5    Tignol, J.6    Burbaud, P.7
  • 8
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their function
    • DOI 10.1016/S0028-3908(99)00010-6, PII S0028390899000106
    • Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-152 (Pubitemid 29292403)
    • (1999) Neuropharmacology , vol.38 , Issue.8 , pp. 1083-1152
    • Barnes, N.M.1    Sharp, T.2
  • 10
    • 0027074323 scopus 로고
    • Neuroimaging studies of obsessive compulsive disorder
    • Baxter LR Jr (1992) Neuroimaging studies of obsessive compulsive disorder. Psychiatr Clin North Am 15:871-884
    • (1992) Psychiatr Clin North Am , vol.15 , pp. 871-884
    • Baxter Jr., L.R.1
  • 11
    • 0035208451 scopus 로고    scopus 로고
    • The morphogenesis of motor rituals in rats treated chronically with the dopamine agonist quinpirole
    • DOI 10.1037//0735-7044.115.6.1301
    • Ben Pazi A, Szechtman H, Eilam D (2001) The morphogenesis of motor rituals in rats treated chronically with the dopamine agonist quinpirole. Behav Neurosci 115:1301-1317 (Pubitemid 33139137)
    • (2001) Behavioral Neuroscience , vol.115 , Issue.6 , pp. 1301-1317
    • Ben-Pazi, A.1    Szechtman, H.2    Eilam, D.3
  • 12
    • 33745608054 scopus 로고    scopus 로고
    • A systematic review: Antipsychotic augmentation with treatment refractory obsessive-compulsive disorder
    • DOI 10.1038/sj.mp.4001823, PII 4001823
    • Bloch MH, Landeros-Weisenberger A, Kelmendi B, Coric V, Bracken MB, Leckman JF (2006) A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol Psychiatry 11:622-632 (Pubitemid 43989810)
    • (2006) Molecular Psychiatry , vol.11 , Issue.7 , pp. 622-632
    • Bloch, M.H.1    Landeros-Weisenberger, A.2    Kelmendi, B.3    Coric, V.4    Bracken, M.B.5    Leckman, J.F.6
  • 13
    • 0030610606 scopus 로고    scopus 로고
    • 2c receptors. Synthesis and biological evaluation of substituted 2-(Indol-1-yl), 1-methylethylamines and 2-(Indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder
    • DOI 10.1021/jm970030l
    • Bos M, Jenck F, Martin JR, Moreau JL, Sleight AJ, Wichmann J, Widmer U (1997) Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl) -1-methylethylamines. Improved therapeutics for obsessive compulsive disorder. J Med Chem 40:2762-2769 (Pubitemid 27366457)
    • (1997) Journal of Medicinal Chemistry , vol.40 , Issue.17 , pp. 2762-2769
    • Bos, M.1    Jenck, F.2    Martin, J.R.3    Moreau, J.-L.4    Sleight, A.J.5    Wichmann, J.6    Widmer, U.7
  • 14
    • 45149127256 scopus 로고    scopus 로고
    • 2C receptor antagonists on serial spatial reversal learning in rats
    • DOI 10.1038/sj.npp.1301584, PII 1301584
    • Boulougouris V, Glennon JC, Robbins TW (2008) Dissociable effects of selective 5-HT2A and 5-HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology 33:2007-2019 (Pubitemid 351832598)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.8 , pp. 2007-2019
    • Boulougouris, V.1    Glennon, J.C.2    Robbins, T.W.3
  • 15
    • 0032474508 scopus 로고    scopus 로고
    • Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder (OCD): Behavioral and biological results
    • DOI 10.1016/S0165-1781(98)00029-8, PII S0165178198000298
    • Broocks A, Pigott TA, Hill JL, Stephanie C, Grady TA, L'Heureux F, Murphy DL (1998) Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder (OCD): behavioral and biological results. Psychiatry Res 79:11-20 (Pubitemid 28318238)
    • (1998) Psychiatry Research , vol.79 , Issue.1 , pp. 11-20
    • Broocks, A.1    Pigott, T.A.2    Hill, J.L.3    Stephanie, C.4    Grady, T.A.5    L'Heureux, F.6    Murphy, D.L.7
  • 17
    • 0036890466 scopus 로고    scopus 로고
    • Elevated levels of GluR1 in the midbrain: A trigger for sensitization to drugs of abuse?
    • Carlezon WA Jr, Nestler EJ (2002) Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci 25:610-615
    • (2002) Trends Neurosci , vol.25 , pp. 610-615
    • Carlezon Jr., W.A.1    Nestler, E.J.2
  • 18
    • 0037469962 scopus 로고    scopus 로고
    • Differences in quinpirole-induced local cerebral glucose utilization between naive and sensitized rats
    • DOI 10.1016/S0006-8993(02)04115-X
    • Carpenter TL, Pazdernik TL, Levant B (2003) Differences in quinpirole-induced local cerebral glucose utilization between naive and sensitized rats. Brain Res 964:295-301 (Pubitemid 36165154)
    • (2003) Brain Research , vol.964 , Issue.2 , pp. 295-301
    • Carpenter, T.L.1    Pazdernik, T.L.2    Levant, B.3
  • 19
    • 0023860008 scopus 로고
    • Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects
    • Charney DS, Goodman WK, Price LH, Woods SW, Rasmussen SA, Heninger GR (1988) Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Arch Gen Psychiatry 45:177-85 (Pubitemid 18052850)
    • (1988) Archives of General Psychiatry , vol.45 , Issue.2 , pp. 177-185
    • Charney, D.S.1    Goodman, W.K.2    Price, L.H.3    Woods, S.W.4    Rasmussen, S.A.5    Heninger, G.R.6
  • 20
    • 49949098406 scopus 로고    scopus 로고
    • Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: Effects of pre-treatment with Ro 41-1049
    • Culver KE, Szechtman H, Levant B (2008) Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049. Eur J Pharmacol 592:67-72
    • (2008) Eur J Pharmacol , vol.592 , pp. 67-72
    • Culver, K.E.1    Szechtman, H.2    Levant, B.3
  • 21
    • 47849094106 scopus 로고    scopus 로고
    • Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo
    • de Leeuw AS, Westenberg HG (2008) Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo. J Psychiatr Res 42:894-901
    • (2008) J Psychiatr Res , vol.42 , pp. 894-901
    • De Leeuw, A.S.1    Westenberg, H.G.2
  • 22
    • 33646140558 scopus 로고    scopus 로고
    • Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
    • Denys D (2006) Pharmacotherapy of obsessive-compulsive disorder and obsessive-compulsive spectrum disorders. Psychiatr Clin North Am 29:553-584
    • (2006) Psychiatr Clin North Am , vol.29 , pp. 553-584
    • Denys, D.1
  • 24
    • 0034829038 scopus 로고    scopus 로고
    • SEE: A tool for the visualization and analysis of rodent exploratory behavior
    • DOI 10.1016/S0149-7634(01)00022-7, PII S0149763401000227
    • Drai D, Golani I (2001) SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci Biobehav Rev 25:409-426 (Pubitemid 32879298)
    • (2001) Neuroscience and Biobehavioral Reviews , vol.25 , Issue.5 , pp. 409-426
    • Drai, D.1    Golani, I.2
  • 25
    • 0034654483 scopus 로고    scopus 로고
    • Statistical discrimination of natural modes of motion in rat exploratory behavior
    • DOI 10.1016/S0165-0270(99)00194-6, PII S0165027099001946
    • Drai D, Benjamini Y, Golani I (2000) Statistical discrimination of natural modes of motion in rat exploratory behavior. J Neurosci Methods 96:119-131 (Pubitemid 30138057)
    • (2000) Journal of Neuroscience Methods , vol.96 , Issue.2 , pp. 119-131
    • Drai, D.1    Benjamini, Y.2    Golani, I.3
  • 26
    • 33645069657 scopus 로고    scopus 로고
    • Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder
    • Dvorkin A, Perreault ML, Szechtman H (2006) Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder. Behav Brain Res 169:303-311
    • (2006) Behav Brain Res , vol.169 , pp. 303-311
    • Dvorkin, A.1    Perreault, M.L.2    Szechtman, H.3
  • 27
    • 78149255370 scopus 로고    scopus 로고
    • Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex
    • Dvorkin A, Silva C, McMurran T, Bisnaire L, Foster J, Szechtman H (2010) Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. Eur J Neurosci 32:1552-1563
    • (2010) Eur J Neurosci , vol.32 , pp. 1552-1563
    • Dvorkin, A.1    Silva, C.2    McMurran, T.3    Bisnaire, L.4    Foster, J.5    Szechtman, H.6
  • 28
    • 0024414254 scopus 로고
    • Home base behavior of rats (Rattus norvegicus) exploring a novel environment
    • Eilam D, Golani I (1989) Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behav Brain Res 34:199-211 (Pubitemid 19214768)
    • (1989) Behavioural Brain Research , vol.34 , Issue.3 , pp. 199-211
    • Eilam, D.1    Golani, I.2
  • 29
    • 16844379173 scopus 로고    scopus 로고
    • Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: An ethological approach to the form of compulsive rituals
    • Eilam D, Szechtman H (2005) Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals. CNS Spectr 10:191-202 (Pubitemid 40489289)
    • (2005) CNS Spectrums , vol.10 , Issue.3 , pp. 191-202
    • Eilam, D.1    Szechtman, H.2
  • 30
    • 0028816558 scopus 로고
    • Perseveration without hyperlocomotion in a spontaneous alternation task in rats sensitized to the dopamine agonist quinpirole
    • Einat H, Szechtman H (1995) Perseveration without hyperlocomotion in a spontaneous alternation task in rats sensitized to the dopamine agonist quinpirole. Physiol Behav 57:55-9
    • (1995) Physiol Behav , vol.57 , pp. 55-59
    • Einat, H.1    Szechtman, H.2
  • 31
    • 33645233540 scopus 로고    scopus 로고
    • A review of antipsychotics in the treatment of obsessive compulsive disorder
    • Fineberg NA, Gale TM, Sivakumaran T (2006) A review of antipsychotics in the treatment of obsessive compulsive disorder. J Psychopharmacol 20:97-103
    • (2006) J Psychopharmacol , vol.20 , pp. 97-103
    • Fineberg, N.A.1    Gale, T.M.2    Sivakumaran, T.3
  • 32
    • 37549064027 scopus 로고    scopus 로고
    • 5-HT receptor regulation of neurotransmitter release
    • Fink KB, Göthert M (2007) 5-HT receptor regulation of neurotransmitter release. Pharmacol Rev 59:360-417
    • (2007) Pharmacol Rev , vol.59 , pp. 360-417
    • Fink, K.B.1    Göthert, M.2
  • 33
    • 50849118848 scopus 로고    scopus 로고
    • The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessivecompulsive disorder
    • Flaisher-Grinberg S, Klavir O, Joel D (2008) The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessivecompulsive disorder. Int J Neuropsychopharmacol 11:811-25
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 811-825
    • Flaisher-Grinberg, S.1    Klavir, O.2    Joel, D.3
  • 34
    • 0038489422 scopus 로고    scopus 로고
    • Discriminative st imulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety
    • Gatch MB (2003) Discriminative st imulus effects of m- chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life Sci 73:1347-1367
    • (2003) Life Sci , vol.73 , pp. 1347-1367
    • Gatch, M.B.1
  • 35
    • 0027458604 scopus 로고
    • Stopping behavior: Constraints on exploration in rats (Rattus norvegicus)
    • Golani I, Benjamini Y, Eilam D (1993) Stopping behavior: constraints on exploration in rats (Rattus norvegicus). Behav Brain Res 53:21-33 (Pubitemid 23074027)
    • (1993) Behavioural Brain Research , vol.53 , Issue.1-2 , pp. 21-33
    • Golani, I.1    Benjamini, Y.2    Eilam, D.3
  • 36
    • 0025161710 scopus 로고
    • Beyond the serotonin hypothesis: A role for dopamine in some forms of obsessive compulsive disorder?
    • discussion 55-58
    • Goodman WK, McDougle CJ, Price LH, Riddle MA, Pauls DL, Leckman JF (1990) Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder? J Clin Psychiatry 51(Suppl):36-43, discussion 55-58
    • (1990) J Clin Psychiatry , vol.51 , Issue.SUPPL. , pp. 36-43
    • Goodman, W.K.1    McDougle, C.J.2    Price, L.H.3    Riddle, M.A.4    Pauls, D.L.5    Leckman, J.F.6
  • 38
    • 0033636505 scopus 로고    scopus 로고
    • Toward a neurobiology of obsessive-compulsive disorder
    • Graybiel AM, Rauch SL (2000) Toward a neurobiology of obsessive-compulsive disorder. Neuron 28:343-347
    • (2000) Neuron , vol.28 , pp. 343-347
    • Graybiel, A.M.1    Rauch, S.L.2
  • 40
    • 4644346877 scopus 로고    scopus 로고
    • Serotonergic dissection of obsessive compulsive symptoms: A challenge study with m-chlorophenylpiperazine and sumatriptan
    • DOI 10.1159/000079970
    • Gross-Isseroff R, Cohen R, Sasson Y, Voet H, Zohar J (2004) Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan. Neuropsychobiology 50:200-5 (Pubitemid 39279410)
    • (2004) Neuropsychobiology , vol.50 , Issue.3 , pp. 200-205
    • Gross-Isseroff, R.1    Cohen, R.2    Sasson, Y.3    Voet, H.4    Zohar, J.5
  • 41
    • 79954589565 scopus 로고    scopus 로고
    • 5-HT receptors and reward-related behaviour: A review
    • Hayes DJ, Greenshaw AJ (2011) 5-HT receptors and reward-related behaviour: a review. Neurosci Biobehav Rev 35:1419-1449
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 1419-1449
    • Hayes, D.J.1    Greenshaw, A.J.2
  • 42
    • 0742272070 scopus 로고    scopus 로고
    • The dynamics of spatial behavior: How can robust smoothing techniques help?
    • DOI 10.1016/j.jneumeth.2003.10.013
    • Hen I, Sakov A, Kafkafi N, Golani I, Benjamini Y (2004) The dynamics of spatial behavior: how can robust smoothing techniques help? J Neurosci Methods 133:161-172 (Pubitemid 38147768)
    • (2004) Journal of Neuroscience Methods , vol.133 , Issue.1-2 , pp. 161-172
    • Hen, I.1    Sakov, A.2    Kafkafi, N.3    Golani, I.4    Benjamini, Y.5
  • 44
    • 84856289525 scopus 로고    scopus 로고
    • When too much is not enough: Obsessive-compulsive disorder as a pathology of stopping, rather than starting
    • Hinds AL, Woody EZ, Van Ameringen M, Schmidt LA, Szechtman H (2012) When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting. PLoS ONE 7:e30586
    • (2012) PLoS ONE , vol.7
    • Hinds, A.L.1    Woody, E.Z.2    Van Ameringen, M.3    Schmidt, L.A.4    Szechtman, H.5
  • 45
    • 0345267247 scopus 로고    scopus 로고
    • Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive-compulsive disorder and controls
    • DOI 10.1016/S0006-3223(97)00458-7, PII S0006322397004587
    • Ho Pian KL, Westenberg HG, den Boer JA, de Bruin WI, van Rijk PP (1998) Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive-compulsive disorder and controls. Biol Psychiatry 44:367-70 (Pubitemid 28432649)
    • (1998) Biological Psychiatry , vol.44 , Issue.5 , pp. 367-370
    • Ho, P.K.L.1    Westenberg, H.G.M.2    Den, B.J.A.3    De Bruin, W.I.4    Van Rijk, P.P.5
  • 46
    • 84857017715 scopus 로고    scopus 로고
    • D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout's repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior
    • Hoffman KL, Rueda Morales RI (2012) D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout's repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior. Behav Brain Res 230:1-10
    • (2012) Behav Brain Res , vol.230 , pp. 1-10
    • Hoffman, K.L.1    Rueda Morales, R.I.2
  • 47
    • 0026035082 scopus 로고
    • Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to metachlorophenylpiperazine in obsessive-compulsive disorder
    • Hollander E, DeCaria C, Gully R, Nitescu A, Suckow RF, Gorman JM, Klein DF, Liebowitz MR (1991) Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to metachlorophenylpiperazine in obsessive-compulsive disorder. Psychiatry Res 36:1-17
    • (1991) Psychiatry Res , vol.36 , pp. 1-17
    • Hollander, E.1    DeCaria, C.2    Gully, R.3    Nitescu, A.4    Suckow, R.F.5    Gorman, J.M.6    Klein, D.F.7    Liebowitz, M.R.8
  • 49
    • 0027055218 scopus 로고
    • Neurobiology of obsessive compulsive disorder: A review
    • Insel TR (1992) Neurobiology of obsessive compulsive disorder: a review. Int Clin Psychopharmacol 7(Suppl 1):31-33, 31-33
    • (1992) Int Clin Psychopharmacol , vol.7 , Issue.SUPPL. 1
    • Insel, T.R.1
  • 50
    • 0022220570 scopus 로고
    • Obsessive-compulsive disorder and serotonin: Is there a connection?
    • DOI 10.1016/0006-3223(85)90176-3
    • Insel TR, Mueller EA, Alterman I, Linnoila M, Murphy DL (1985) Obsessive-compulsive disorder and serotonin: is there a connection? Biol Psychiatry 20:1174-1188 (Pubitemid 16053592)
    • (1985) Biological Psychiatry , vol.20 , Issue.11 , pp. 1174-1188
    • Insel, T.R.1    Mueller, E.A.2    Alterman, I.3
  • 51
    • 80052925171 scopus 로고    scopus 로고
    • Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety
    • Jimenez-Gomez C, Osentoski A, Woods JH (2011) Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety. Behav Pharmacol 22:711-713
    • (2011) Behav Pharmacol , vol.22 , pp. 711-713
    • Jimenez-Gomez, C.1    Osentoski, A.2    Woods, J.H.3
  • 52
    • 33744962934 scopus 로고    scopus 로고
    • The signal attenuation rat model of obsessive-compulsive disorder: A review
    • Joel D (2006) The signal attenuation rat model of obsessive-compulsive disorder: a review. Psychopharmacol (Berl) 186:487-503
    • (2006) Psychopharmacol (Berl) , vol.186 , pp. 487-503
    • Joel, D.1
  • 53
    • 0035215558 scopus 로고    scopus 로고
    • 2 antagonist haloperidol
    • DOI 10.1037//0735-7044.115.6.1291
    • Joel D, Avisar A, Doljansky J (2001) Enhancement of excessive lever-pressing after post-training signal attenuation in rats by repeated administration of the D1 antagonist SCH 23390 or the D2 agonist quinpirole, but not the D1 agonist SKF 38393 or the D2 antagonist haloperidol. Behav Neurosci 115:1291-1300 (Pubitemid 33139136)
    • (2001) Behavioral Neuroscience , vol.115 , Issue.6 , pp. 1291-1300
    • Joel, D.1    Avisar, A.2    Doljansky, J.3
  • 54
    • 0035219188 scopus 로고    scopus 로고
    • Neuroendocrine and behavioral responses to mCPP in obsessive-compulsive disorder
    • Khanna S, John JP, Lakshmi Reddy P (2001) Neuroendocrine and behavioral responses to mCPP in obsessive-compulsive disorder. Psychoneuroendocrinology 26:209-223
    • (2001) Psychoneuroendocrinology , vol.26 , pp. 209-223
    • Khanna, S.1    John, J.P.2    Lakshmi Reddy, P.3
  • 56
    • 38749088723 scopus 로고    scopus 로고
    • Stereotypic behaviour in the deer mouse: Pharmacological validation and relevance for obsessive compulsive disorder
    • DOI 10.1016/j.pnpbp.2007.08.032, PII S027858460700320X
    • Korff S, Stein DJ, Harvey BH (2008) Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 32:348-355 (Pubitemid 351178945)
    • (2008) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.32 , Issue.2 , pp. 348-355
    • Korff, S.1    J, S.D.2    H, H.B.3
  • 57
    • 4344700352 scopus 로고    scopus 로고
    • Effects of quinpirole on operant conditioning: Perseveration of behavioral components
    • Kurylo DD (2004) Effects of quinpirole on operant conditioning: perseveration of behavioral components. Behav Brain Res 155:117-124
    • (2004) Behav Brain Res , vol.155 , pp. 117-124
    • Kurylo, D.D.1
  • 59
    • 0024427173 scopus 로고
    • Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder
    • Modell JG, Mountz JM, Curtis GC, Greden JF (1989) Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 1:27-36 (Pubitemid 19247050)
    • (1989) Journal of Neuropsychiatry and Clinical Neurosciences , vol.1 , Issue.1 , pp. 27-36
    • Modell, J.G.1    Mountz, J.M.2    Curtis, G.C.3    Greden, J.F.4
  • 63
    • 33747341585 scopus 로고    scopus 로고
    • Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: Pre- and postsynaptic mechanisms
    • Perreault ML, Graham D, Bisnaire L, Simms J, Hayton S, Szechtman H (2005) Kappa-opioid agonist U69593 potentiates locomotor sensitization to the D2/D3 agonist quinpirole: pre- and postsynaptic mechanisms. Neuropsychopharmacology 31:1967-1981
    • (2005) Neuropsychopharmacology , vol.31 , pp. 1967-1981
    • Perreault, M.L.1    Graham, D.2    Bisnaire, L.3    Simms, J.4    Hayton, S.5    Szechtman, H.6
  • 64
    • 35748954389 scopus 로고    scopus 로고
    • Kappa-Opioid Receptor Stimulation Quickens Pathogenesis of Compulsive Checking in the Quinpirole Sensitization Model of Obsessive-Compulsive Disorder (OCD)
    • DOI 10.1037/0735-7044.121.5.976, PII S0735704407605369
    • Perreault ML, Seeman P, Szechtman H (2007) Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole Sensitization model of obsessive-compulsive disorder (OCD). Behav Neurosci 121:976-991 (Pubitemid 350051300)
    • (2007) Behavioral Neuroscience , vol.121 , Issue.5 , pp. 976-991
    • Perreault, M.L.1    Seeman, P.2    Szechtman, H.3
  • 65
    • 0027458735 scopus 로고
    • A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP
    • DOI 10.1016/0006-3223(93)90272-F
    • Pigott TA, Hill JL, Grady TA, L'Heureux F, Bernstein S, Rubenstein CS, Murphy DL (1993) A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biol Psychiatry 33:3-14 (Pubitemid 23042675)
    • (1993) Biological Psychiatry , vol.33 , Issue.1 , pp. 3-14
    • Pigott, T.A.1    Hill, J.L.2    Grady, T.A.3    L'Heureux, F.4    Bernstein, S.5    Rubenstein, C.S.6    Murphy, D.L.7
  • 66
    • 0024411940 scopus 로고
    • Animal models of compulsive behavior
    • Pitman RK (1989) Animal models of compulsive behavior. Biol Psychiatry 26:189-198
    • (1989) Biol Psychiatry , vol.26 , pp. 189-198
    • Pitman, R.K.1
  • 67
    • 62949112001 scopus 로고    scopus 로고
    • 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT2A receptors: Proposal of a modified rodent antidepressant assay
    • Rajkumar R, Pandey DK, Mahesh R, Radha R (2009) 1-(m-Chlorophenyl) piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT2A receptors: proposal of a modified rodent antidepressant assay. Eur J Pharmacol 608:32-41
    • (2009) Eur J Pharmacol , vol.608 , pp. 32-41
    • Rajkumar, R.1    Pandey, D.K.2    Mahesh, R.3    Radha, R.4
  • 68
    • 17044367836 scopus 로고    scopus 로고
    • Altered quinpirole-induced local cerebral glucose utilization in anterior cortical regions in rats after sensitization to quinpirole
    • Richards TL, Pazdernik TL, Levant B (2005) Altered quinpirole-induced local cerebral glucose utilization in anterior cortical regions in rats after sensitization to quinpirole. Brain Res 1042:53-61
    • (2005) Brain Res , vol.1042 , pp. 53-61
    • Richards, T.L.1    Pazdernik, T.L.2    Levant, B.3
  • 69
    • 0035318505 scopus 로고    scopus 로고
    • Brain-behavior relationships in obsessive-compulsive disorder
    • Saxena S, Bota RG, Brody AL (2001) Brain-behavior relationships in obsessive-compulsive disorder. Semin Clin Neuropsychiatry 6:82-101
    • (2001) Semin Clin Neuropsychiatry , vol.6 , pp. 82-101
    • Saxena, S.1    Bota, R.G.2    Brody, A.L.3
  • 70
    • 84876062987 scopus 로고    scopus 로고
    • Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior
    • Schepisi C, De Carolis L, Nencini P (2013) Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior. Psychopharmacol (Berl) 227:55-66
    • (2013) Psychopharmacol (Berl) , vol.227 , pp. 55-66
    • Schepisi, C.1    De Carolis, L.2    Nencini, P.3
  • 71
    • 76749089572 scopus 로고    scopus 로고
    • The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: Possible involvement of the serotonergic system
    • Schilman EA, Klavir O, Winter C, Sohr R, Joel D (2010) The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system. Neuropsychopharmacology 35:1026-1039
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1026-1039
    • Schilman, E.A.1    Klavir, O.2    Winter, C.3    Sohr, R.4    Joel, D.5
  • 73
    • 84878827673 scopus 로고    scopus 로고
    • Evaluation of animal models of obsessive-compulsive disorder: Correlation with phasic dopamine neuron activity
    • Sesia T, Bizup B, Grace AA (2013) Evaluation of animal models of obsessive-compulsive disorder: correlation with phasic dopamine neuron activity. International Journal of Neuropsychopharmacology: 1-13
    • (2013) International Journal of Neuropsychopharmacology , pp. 1-13
    • Sesia, T.1    Bizup, B.2    Grace, A.A.3
  • 74
    • 80155193446 scopus 로고    scopus 로고
    • Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice
    • Shanahan NA, Velez LP, Masten VL, Dulawa SC (2011) Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biol Psychiatry 70:1039-48
    • (2011) Biol Psychiatry , vol.70 , pp. 1039-1048
    • Shanahan, N.A.1    Velez, L.P.2    Masten, V.L.3    Dulawa, S.C.4
  • 75
    • 0034831096 scopus 로고    scopus 로고
    • The EthoVision video tracking system - A tool for behavioral phenotyping of transgenic mice
    • DOI 10.1016/S0031-9384(01)00530-3, PII S0031938401005303
    • Spink AJ, Tegelenbosch RA, Buma MO, Noldus LP (2001) The EthoVision video tracking system - a tool for behavioral phenotyping of transgenic mice. Physiol Behav 73:731-744 (Pubitemid 32885562)
    • (2001) Physiology and Behavior , vol.73 , Issue.5 , pp. 731-744
    • Spink, A.J.1    Tegelenbosch, R.A.J.2    Buma, M.O.S.3    Noldus, L.P.J.J.4
  • 76
    • 0037014867 scopus 로고    scopus 로고
    • Obsessive-compulsive disorder
    • Stein DJ (2002) Obsessive-compulsive disorder. Lancet 360:397-405
    • (2002) Lancet , vol.360 , pp. 397-405
    • Stein, D.J.1
  • 77
    • 0032484505 scopus 로고    scopus 로고
    • Effects of quinpirole on central dopamine systems in sensitized and non- sensitized rats
    • DOI 10.1016/S0306-4522(97)00412-0, PII S0306452297004120
    • Sullivan RM, Talangbayan H, Einat H, Szechtman H (1998) Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 83:781-9 (Pubitemid 28068898)
    • (1998) Neuroscience , vol.83 , Issue.3 , pp. 781-789
    • Sullivan, R.M.1    Talangbayan, H.2    Einat, H.3    Szechtman, H.4
  • 79
    • 0742323861 scopus 로고    scopus 로고
    • Obsessive-Compulsive Disorder as a Disturbance of Security Motivation
    • DOI 10.1037/0033-295X.111.1.111
    • Szechtman H, Woody E (2004) Obsessive-compulsive disorder as a disturbance of security motivation. Psychol Rev 111:111-127 (Pubitemid 38157078)
    • (2004) Psychological Review , vol.111 , Issue.1 , pp. 111-127
    • Szechtman, H.1    Woody, E.2
  • 80
    • 0028043115 scopus 로고
    • Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole
    • DOI 10.1016/0091-3057(94)90201-1
    • Szechtman H, Dai H, Mustafa S, Einat H, Sullivan RM (1994a) Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole. Pharmacol Biochem Behav 48:921-928 (Pubitemid 24259822)
    • (1994) Pharmacology Biochemistry and Behavior , vol.48 , Issue.4 , pp. 921-928
    • Szechtman, H.1    Dai, H.2    Mustafa, S.3    Einat, H.4    Sullivan, R.M.5
  • 81
    • 0028360983 scopus 로고
    • Dynamics of behavioral sensitization induced by the dopamine agonist quinpirole and a proposed central energy control mechanism
    • published erratum appears in Psychopharmacology (Berl) 1994Sep;116(1):124.
    • Szechtman H, Talangbayan H, Canaran G, Dai H, Eilam D (1994b) Dynamics of behavioral sensitization induced by the dopamine agonist quinpirole and a proposed central energy control mechanism [published erratum appears in Psychopharmacology (Berl) 1994Sep;116(1):124]. Psychopharmacol (Berl) 115:95-104
    • (1994) Psychopharmacol (Berl) , vol.115 , pp. 95-104
    • Szechtman, H.1    Talangbayan, H.2    Canaran, G.3    Dai, H.4    Eilam, D.5
  • 82
    • 0032441547 scopus 로고    scopus 로고
    • Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD)
    • Szechtman H, Sulis W, Eilam D (1998) Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 112:1475-1485
    • (1998) Behav Neurosci , vol.112 , pp. 1475-1485
    • Szechtman, H.1    Sulis, W.2    Eilam, D.3
  • 83
    • 84906938286 scopus 로고    scopus 로고
    • Pathophysiology of obsessive-compulsive disorder: Insights from normal function and neurotoxic effects of drugs, infection and brain injury
    • Kostrzewa RM (ed) Springer London, Limited
    • Szechtman H, Shivji S, Woody EZ (2013) Pathophysiology of obsessive-compulsive disorder: insights from normal function and neurotoxic effects of drugs, infection and brain injury. In: Kostrzewa RM (ed) Handbook of neurotoxicity. Springer London, Limited
    • (2013) Handbook of Neurotoxicity
    • Szechtman, H.1    Shivji, S.2    Woody, E.Z.3
  • 84
    • 0030813682 scopus 로고    scopus 로고
    • Locomotor sensitization to quinpirole: Environment-modulated increase in efficacy and context-dependent increase in potency
    • DOI 10.1007/s002130050442
    • Szumlinski KK, Allan M, Talangbayan H, Tracey A, Szechtman H (1997) Locomotor sensitization to quinpirole: environment-modulated increase in efficacy and context-dependent increase in potency. Psychopharmacoly (Berl) 134:193-200 (Pubitemid 27522576)
    • (1997) Psychopharmacology , vol.134 , Issue.2 , pp. 193-200
    • Szumlinski, K.K.1    Allan, M.2    Talangbayan, H.3    Tracey, A.4    Szechtman, H.5
  • 85
    • 0033118786 scopus 로고    scopus 로고
    • To split behaviour into bouts, log-transform the intervals
    • DOI 10.1006/anbe.1998.1022
    • Tolkamp BJ, Kyriazakis I (1999) To split behaviour into bouts, log-transform the intervals. Anim Behav 57:807-817 (Pubitemid 29186605)
    • (1999) Animal Behaviour , vol.57 , Issue.4 , pp. 807-817
    • Tolkamp, B.J.1    Kyriazakis, I.2
  • 89
    • 0025370554 scopus 로고
    • Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: Lack of conditioned effects
    • DOI 10.1016/0006-8993(90)90902-N
    • Vezina P, Stewart J (1990) Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects. Brain Res 516:99-106 (Pubitemid 20189205)
    • (1990) Brain Research , vol.516 , Issue.1 , pp. 99-106
    • Vezina, P.1    Stewart, J.2
  • 90
    • 84913603549 scopus 로고    scopus 로고
    • Neurobiology of obsessive-compulsive disorder: Serotonin and beyond
    • Westenberg HG, Fineberg NA, Denys D (2007) Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr 12:14-27
    • (2007) CNS Spectr , vol.12 , pp. 14-27
    • Westenberg, H.G.1    Fineberg, N.A.2    Denys, D.3
  • 91
    • 0000645386 scopus 로고
    • Obsessive compulsive disorder - Is it a basal ganglia dysfunction?
    • Rapoport J (ed) American Psychiatric Press, Washington, DC
    • Wise S, Rapoport JL (1989) Obsessive compulsive disorder - is it a basal ganglia dysfunction? In: Rapoport J (ed) Obsessive compulsive disorder in children and adolescence. American Psychiatric Press, Washington, DC, pp 327-344
    • (1989) Obsessive Compulsive Disorder in Children and Adolescence , pp. 327-344
    • Wise, S.1    Rapoport, J.L.2
  • 92
    • 23844548906 scopus 로고    scopus 로고
    • Motivation, time course, and heterogeneity in obsessive-compulsive disorder: Response to Taylor, McKay, and Abramowitz (2005)
    • DOI 10.1037/0033-295X.112.3.658
    • Woody EZ, Szechtman H (2005) Motivation, time course, and heterogeneity in obsessive-compulsive disorder: response to Taylor, McKay, and Abramowitz (2005). Psychol Rev 112:658-661 (Pubitemid 41151869)
    • (2005) Psychological Review , vol.112 , Issue.3 , pp. 658-661
    • Woody, E.Z.1    Szechtman, H.2
  • 93
    • 79951576408 scopus 로고    scopus 로고
    • Adaptation to potential threat: The evolution, neurobiology, and psychopathology of the security motivation system
    • Woody EZ, Szechtman H (2011) Adaptation to potential threat: the evolution, neurobiology, and psychopathology of the security motivation system. Neurosci Biobehav Rev 35:1019-1033
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 1019-1033
    • Woody, E.Z.1    Szechtman, H.2
  • 94
    • 0026355203 scopus 로고
    • Spontaneous alternation behavior: An animal model for obsessive-compulsive disorder?
    • Yadin E, Friedman E, Bridger WH (1991) Spontaneous alternation behavior: an animal model for obsessive-compulsive disorder? Pharmacol Biochem Behav 40:311-315
    • (1991) Pharmacol Biochem Behav , vol.40 , pp. 311-315
    • Yadin, E.1    Friedman, E.2    Bridger, W.H.3
  • 95
    • 0023501985 scopus 로고
    • Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls
    • Zohar J, Mueller EA, Insel TR, Zohar-Kadouch RC, Murphy DL (1987) Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Arch Gen Psychiatry 44:946-51 (Pubitemid 18009649)
    • (1987) Archives of General Psychiatry , vol.44 , Issue.11 , pp. 946-951
    • Zohar, J.1    Mueller, E.A.2    Insel, T.R.3    Zohar-Kadouch, R.C.4    Murphy, D.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.