OCD-like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons

Journal of Neuroscience

Volumn 19, Issue 12, 1999, Pages 5044-5053

  Campbell, Keith M ^a   De Lecea, Luis ^b   Severynse, Diana M ^c,d   Caron, Marc G ^c   McGrath, Michael J ^a   Sparber, Sheldon B ^a   Sun, Li Yan ^a,e   Burton, Frank H ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d PROCTER AND GAMBLE COMPANY   (United States)

^e Wayne Hughes Institute   (United States)

Author keywords

cAMP; Cholera toxin; D1 receptor; Dopamine; G proteins; Intercalated nucleus; Obsessive compulsive disorder; Piriform; Somatosensory; Stereotypy; Transgenic mice

Indexed keywords

CHOLERA TOXIN; DOPAMINE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CONTROLLED STUDY; GENE EXPRESSION; LIMBIC CORTEX; MALE; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL STIMULATION; NEUROTRANSMISSION; NONHUMAN; OBSESSION; PRIORITY JOURNAL; PYRIFORM CORTEX; SOMATOSENSORY CORTEX; TRANSGENE; TRANSGENIC MOUSE;

EID: 0033564428     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-12-05044.1999     Document Type: Article

References (66)

1. Abel T, Nguyen PV, Borad M, Deuel TA, Kandel ER, Bourtchouladze R (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88:615-626.
2. Alleva E (1993) Assessment of aggressive behavior in rodents. Methods Neurosci 14:111-137.
3. Ariano MA, Sibley DR (1994) Dopamine receptor distribution in the rat CNS: elucidation using anti-peptide antisera directed against D1A and D3 subtypes. Brain Res 649:95-110.
4. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81:905-915.
5. Bachus SE, Kleinman JE (1996) The neuropathology of schizophrenia. J Clin Psychiatry 57:72-83.
6. Barbas H (1993) Organization of cortical afferent input to orbitofrontal areas in the rhesus monkey. Neuroscience 56:841-864.
7. Berendse HW, deGalis GY, Groenewegen HJ (1992) Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol 316:314-347.
8. Bergson C, Mrzlijak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS (1995) Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptor in primate brain. J Neurosci 15:7821-7836.
9. Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological, and neurochemical correlations. J Neurol Sci 20:415-455.
10. Bernstein IC, Callahan WA, Jaranson JM (1975) Lobotomy in private practice. Arch Gen Psychol 32:1041-1047.
11. Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN, Kendrick AD, Davis TL, Jiang A, Cohen MS, Stern CE, Belliveau JW, Baer L, O'Sullivan RL, Savage CR, Jenike MA, Rosen BR (1996) Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Arch Gen Psychiatry 53:595-606.
12. Brown AS, Gershon S (1993) Dopamine and depression. J Neural Transm 91:75-109.
13. Burton FH, Hasel K, Bloom FE, Sutcliffe JG (1991) Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. Nature 350:74-77.
14. Burton FH, Forss-Petter S, Battenberg E, Bloom FE, Sutcliffe JG (1998) Lethal psychomotor abnormalities in mice caused by a neural cholera toxin transgene. Transgenics 2:249-257.
15. Campbell KM, Rohland RM, McGrath MJ, Satoskar SD, Burton FH (1998) Detecting complex repetitive or stereotypic behaviors by graphing behavior as a multifrequency waveform. Physiol Behav 64:83-91.
16. Cepeda C, Buchwald NA, Levine MS (1993) Neuromodulatory actions of dopamine in the neostriatum are dependent on the excitatory amino acid receptor subtypes activated. Proc Natl Acad Sci USA 90:9576-9580.
17. Connolly JB, Roberts JH, Armstrong JD, Kaiser K, Forte M, Tully T, O'Kane CJ (1996) Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies. Science 274:2104-2107.
18. Cunningham ST, Kelley AE (1993) Hyperactivity and sensitization to psychostimulants following cholera toxin infusion into the nucleus accumbens. J Neurosci 13:2342-2350.
19. de Lecea L, del Rio JA, Criado JR, Alcantara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG (1997) Cortistatin is expressed in a distinct subset of cortical interneurons. J Neurosci 17:5868-5880.
20. Delfs JM, Kelly AE (1990) The role of D1 and D2 dopamine receptors in oral stereotypy induced by dopaminergic stimulation of the ventrolateral striatum. Neuroscience 39:59-67.
21. Fray PJ, Sahakian BJ, Robbins TW, Koob GF, Iversen SD (1980) An observational method for quantifying the behavioral effects of dopamine agonists: contrasting effects of D-amphetamine and apomorphine. Psychopharmacology (Berl) 69:253-259.
22. Fremeau Jr RT, Duncan GE, Fornaretto MG, Dearry A, Gingrich JA, Breese GR, Caron MG (1991) Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. Proc Natl Acad Sci USA 88:37772-37776.
23. Gaspar P, Bloch B, LeMoine C (1995) D1 and D2 receptor gene expression in the rat frontal cortex: cellular localization in different classes of efferent neurons. Eur J Neurosci 7:1050-1063.
24. Geller AI, During ML, Haycock JL, Freese A, Neve R (1993) Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively activated adenylate cyclase from a herpes simplex virus type I vector. Proc Natl Acad Sci USA 90:7603-7607.
25. Gerfen CR, Wilson JW (1996) The basal ganglia. Handbook of Chem Neuroanat 12:371-468.
26. Gettys TW, Okonogi K, Tarry WC, Johnston J, Horton C, Taylor IL (1990) Elimination of relative rates of cAMP synthesis and degradation in crude membranes of adipocytes treated with hormones. Second Messengers Phosphoproteins 13:37-49.
27. Gill DM, Meren R (1978) ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the action of adenylate cyclase. Proc Natl Acad Sci USA 75:3050-3054.
28. Grobin AC, Deutch AY (1998) Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat. J Pharmacol Exp Ther 285:350-357.
29. Hen R (1996) Mean genes. Neuron 16:17-21.
30. 2+ conductance. J Neurosci 17:3334-3342.
31. Horwitz B, Swedo SE, Grady CL, Pietrini P, Schapiro MB, Rapoport JL, Rapoport SI (1991) Cerebral metabolic pattern in obsessive-compulsive disorder: altered intercorrelations between regional rates of glucose utilization. Psychiatry Res 40:221-237.
32. Huang Q, Zhou D, Chase K, Gusella JF, Aronia N, DiFiglia M (1992) Immunocytochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre-and postsynaptic localization, and prevalence in the basal ganglia, limbic system and thalamic reticular nucleus. Proc Natl Acad Sci USA 89:11988-11992.
33. Kaneko T, Caria MA, Asanuma H (1994) Information processing within the motor cortex. II. Intracortical connections between neurons receiving somatosensory cortical input and motor output neurons of the cortex. J Comp Neurol 345:172-184.
34. Kurlan R, Kersun J, Ballantine HT, Caine ED (1990) Neurosurgical treatment of severe obsessive-compulsive disorder associated with Tourette's syndrome. Mov Disord 5:152-155.
35. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L (1989) GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340:692-696.
36. Levey AI, Hersch SM, Rye DB, Sunahara RK, Niznik HB, Kitt CA, Price DL, Maggio R, Brann MR, Ciliax BJ (1993) Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proc Natl Acad Sci USA 90:8861-8865.
37. Lidow MS, Goldman-Rakic PS (1994) A common action of clozapine, haloperidol, and remoxipride on D1-and D2-dopaminergic receptors in the primate cerebral cortex. Proc Natl Acad Sci USA 91:4353-4356.
38. Lidow MS, Elsworth JD, Goldman-Rakic PS (1997) Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. J Pharmacol Exp Ther 281:597-603.
39. Mayford M, Wang J, Kandel ER, O'Dell TJ (1995) CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81:891-904.
40. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-1683.
41. McDonald AJ (1987) Organization of amygdaloid projections to the mediodorsal thalamus and prefrontal cortex: a fluorescent retrograde transport study in the rat. J Comp Neurol 261:46-58.
42. McDonald AJ, Augustine JR (1993) Localization of GABA-like immunoreactivity in the monkey amygdala. Neuroscience 52:281-294.
43. McDougle CJ, Goodman WK, Price LH (1994) Dopamine antagonists in tic-related and psychotic spectrum obsessive-compulsive disorder. J Clin Psychiatry 55:24-31.
44. McGeorge AJ, Faull RLM (1989) The organization of the projection from the cerebral cortex to the striatum of the rat. Neuroscience 29:503-537.
45. Ming X, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and dopamine-mediated behavioral responses. Cell 79:729-742.
46. Morecraft RJ, Geula C, Mesulam MM (1992) Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey. J Comp Neurol 323:341-358.
47. Nestler EJ (1997) Schizophrenia: an emerging pathophysiology (news and views). Nature 385:578-579.
48. O'Connell DP, Botkin SJ, Ramos SI, Sibley DR, Ariano MA, Felder RA, Carey RM (1995) Localization of dopamine D1A receptor proteins in rat kidneys. Am J Physiol 268:1185-1197.
49. Ritz MC, Kuhar MJ (1993) Psychostimulant drugs and a dopamine hypothesis regarding addiction: update on recent research. Biochem Soc Symp 59:51-64.
50. Rosen JB, Davis M (1988) Enhancement of acoustic startle by electrical stimulation of the amygdala. Behav Neurosci 102:195-202, 324.
51. Rotenberg A, Mayford M, Hawkins RD, Kandel ER, Muller RU (1996) Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell 87:1351-1361.
52. Scibilia RJ, Lachowicz JE, Kilts CD (1992) Topographic nonoverlapping distribution of D1 and D2 dopamine receptors in the amygdaloid nuclear complex of the rat brain. Synapse 11:146-154.
53. 1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice. Mol Brain Res 30:336-346.
54. Spiegel AM (1996) Defects in G protein-coupled signal transduction in human disease. Annu Rev Physiol 58:143-170.
55. Spooren WPJM, Groenewegen HJ, Cools AR (1991) Subregions of the caudate nucleus and their in-and output channels in oro-facial dyskinesia: a behavioral and retrograde tracing study in the cat. Brain Res 539:85-93.
56. Tomic M, Vukosavic S, Joksimovic J (1997) Acute amphetamine and/or phencyclidine effects on the dopamine receptor specific binding in the rat brain. Eur Neuropsychopharmacol 7:295-301.
57. Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M, Kandel ER, Tonegawa S (1996a) Subregion-and cell type-restricted gene knockout in mouse brain. Cell 87:1317-1326.
58. Tsien JZ, Huerta PT, Tonegawa S (1996b) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87:1327-1338.
59. Walseth TF, Zhang HJ, Olson LK, Schroeder WA, Robertson RP (1989) Increase in Gs and cyclic AMP generation in HIT cells. J Biol Chem 264:21106-21111.
60. Weiner DM, Levey AI, Sunahara RK, Niznik HB, O'Dowd BF, Seeman P, Brann MR (1991) D1 and D2 dopamine receptor mRNA in rat brain. Proc Natl Acad Sci USA 88:1859-1863.
61. Winkler JD, Callison K, Cass SA, Weiss B (1988) Selective down-regulation of D1 dopamine mediated rotational behavior in supersensitive mice. Neuropharmacology 27:439-442.
62. Wogensen L, Ma YH, Grodsky GM, Robertson RP, Burton FH, Sutcliffe JG, Sarvetnick N (1993) Functional effects of transgenic expression of cholera toxin in pancreatic beta-cells. Mol Cell Endocrinol 98:33-42.
63. Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ, Tonegawa S (1994) Elimination of cocaine-induced hyperactivity and dopamine receptor-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 79:945-955.
64. Yamamoto T, Samejima A, Oka H (1990) The mode of synaptic activation of pyramidal neurons in the cat primary somatosensory cortex: an intracellular HRP study. Exp Brain Res 80:12-22.
65. Zeiger MA, Motoyasu S, Gusev Y, Westra WH, Takiyama Y, Dooley WZ, Kohn LD, Levine MA (1997) Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice. Endocrinology 138:3133-3140.
66. Zhang X, Gelowitz DL, Lai CT, Boulton AA, Yu PH (1997) Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70. Eur J Neurosci 9:760-769.