Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD)

Psychopharmacology

Volumn 227, Issue 2, 2013, Pages 277-285

  Tucci, Mark C ^a   Dvorkin Gheva, Anna ^a   Graham, Dawn ^a   Amodeo, Sean ^a   Cheon, Paul ^a   Kirk, Ashley ^a   Peel, John ^a   Taji, Leena ^a   Szechtman, Henry ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Animal model; Behavioral sensitization; mCPP; Obsessive compulsive disorder; Quinpirole; Rat; Serotonin

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; QUINPIROLE; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPULSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; MALE; MOTOR PERFORMANCE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SATIETY; SUBSTANTIA NIGRA PARS RETICULATA;

ANIMALS; BEHAVIOR, ANIMAL; COMPULSIVE BEHAVIOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; OBSESSIVE-COMPULSIVE DISORDER; PIPERAZINES; QUINPIROLE; RATS; RATS, LONG-EVANS; SEROTONIN RECEPTOR AGONISTS; TIME FACTORS;

EID: 84879601843     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-2976-1     Document Type: Article

References (62)

1. Ben Pazi A, Szechtman H, Eilam D (2001) The morphogenesis of motor rituals in rats treated chronically with the dopamine agonist quinpirole. Behav Neurosci 115:1301-1317
2. Berendse HW, Groenewegen HJ, Lohman AH (1992) Compartmental distribution of ventral striatal neurons projecting to the mesencephalon in the rat. The Journal of neuroscience: the official journal of the Society for Neuroscience 12:2079-2103
3. Boyer P, Lienard P (2006) Why ritualized behavior? Precaution systems and action parsing in developmental, pathological and cultural rituals. Behav Brain Sci 29:595-613
4. Broocks A, Pigott TA, Hill JL, Stephanie C, Grady TA, L'Heureux F, Murphy DL (1998) Acute intravenous administration of ondansetron and m-CPP, alone and in combination, in patients with obsessive-compulsive disorder (OCD): behavioral and biological results. Psychiatry Res 79:11-20
5. Charney DS, Goodman WK, Price LH, Woods SW, Rasmussen SA, Heninger GR (1988) Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Arch Gen Psychiatry 45:177-185
6. de Leeuw AS, Westenberg HG (2008) Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo. J Psychiatr Res 42:894-901
7. Deniau JM, Menetrey A, Thierry AM (1994) Indirect nucleus accumbens input to the prefrontal cortex via the substantia nigra pars reticulata: a combined anatomical and electrophysiological study in the rat. Neuroscience 61:533-545
8. Djodari-Irani A, Klein J, Banzhaf J, Joel D, Heinz A, Harnack D, Lagemann T, Juckel G, Kupsch A, Morgenstern R, Winter C (2011) Activity modulation of the globus pallidus and the nucleus entopeduncularis affects compulsive checking in rats. Behav Brain Res 219:149-158
9. Drai D, Golani I (2001) SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci Biobehav Rev 25:409-426
10. Drai D, Benjamini Y, Golani I (2000) Statistical discrimination of natural modes of motion in rat exploratory behavior. J Neurosci Methods 96:119-131
11. Dvorkin A, Perreault ML, Szechtman H (2006) Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder. Behav Brain Res 169:303-311
12. Dvorkin A, Silva C, McMurran T, Bisnaire L, Foster J, Szechtman H (2010) Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. Eur J Neurosci 32:1552-1563
13. Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurol 384:233-247
14. Eilam D, Golani I (1989) Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behav Brain Res 34:199-211
15. Eilam D, Szechtman H (2005) Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals. CNS Spectr 10:191-202
16. El Mansari M, Blier P (2006) Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 30:362-373
17. Feygin DL, Swain JE, Leckman JF (2006) The normalcy of neurosis: evolutionary origins of obsessive-compulsive disorder and related behaviors. Prog Neuropsychopharmacol Biol Psychiatry 30:854-864
18. Foa EB, Liebowitz MR, Kozak MJ, Davies S, Campeas R, Franklin ME, Huppert JD, Kjernisted K, Rowan V, Schmidt AB, Simpson HB, Tu X (2005) Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. Am J Psychiatry 162:151-161
19. Golani I, Benjamini Y, Eilam D (1993) Stopping behavior: constraints on exploration in rats (Rattus norvegicus). Behav Brain Res 53:21-33
20. Goodman WK, McDougle CJ, Price LH, Barr LC, Hills OF, Caplik JF, Charney DS, Heninger GR (1995) m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: absence of symptom exacerbation. Biol Psychiatry 38:138-149
21. Greenberg BD, Malone DA, Friehs GM, Rezai AR, Kubu CS, Malloy PF, Salloway SP, Okun MS, Goodman WK, Rasmussen SA (2006) Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 31:2384-2393
22. Gross-Isseroff R, Cohen R, Sasson Y, Voet H, Zohar J (2004) Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan. Neuropsychobiology 50:200-205
23. Hamada S, Senzaki K, Hamaguchi-Hamada K, Tabuchi K, Yamamoto H, Yamamoto T, Yoshikawa S, Okano H, Okado N (1998) Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Brain Res Mol Brain Res 54:199-211
24. Heimer L, Zahm DS, Churchill L, Kalivas PW, Wohltmann C (1991) Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41:89-125
25. Hen I, Sakov A, Kafkafi N, Golani I, Benjamini Y (2004) The dynamics of spatial behavior: how can robust smoothing techniques help? J Neurosci Methods 133:161-172
26. Ho Pian KL, Westenberg HG, den Boer JA, de Bruin WI, van Rijk PP (1998) Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive-compulsive disorder and controls. Biol Psychiatry 44:367-370
27. Hoffman KL (2011) Animal models of obsessive compulsive disorder: recent findings and future directions. Expert Opin Drug Discov 6:725-737
28. Hollander E, DeCaria C, Gully R, Nitescu A, Suckow RF, Gorman JM, Klein DF, Liebowitz MR (1991) Effects of chronic fluoxetine treatment on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine in obsessive-compulsive disorder. Psychiatry Res 36:1-17
29. Joel D (2006) Current animal models of obsessive compulsive disorder: a critical review. Prog Neuropsychopharmacol Biol Psychiatry 30:374-388
30. Kahn RS, Wetzler S (1991) m-Chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry 30:1139-1166
31. Khanna S, John JP, Lakshmi Reddy P (2001) Neuroendocrine and behavioral responses to mCPP in obsessive-compulsive disorder. Psychoneuroendocrinology 26:209-223
32. Kontis D, Boulougouris V, Papakosta VM, Kalogerakou S, Papadopoulos S, Poulopoulou C, Papadimitriou GN, Tsaltas E (2008) Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder. Psychopharmacology (Berl) 200:597-610
33. Korff S, Harvey BH (2006) Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacology. Psychiatr Clin North Am 29:371-390
34. Korff S, Stein DJ, Harvey BH (2008) Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 32:348-355
35. Lind C, Boschen MJ (2009) Intolerance of uncertainty mediates the relationship between responsibility beliefs and compulsive checking. J Anxiety Disord 23:1047-1052
36. Lundberg S, Carlsson A, Norfeldt P, Carlsson ML (2004) Nicotine treatment of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 28:1195-1199
37. Man J, Hudson AL, Ashton D, Nutt DJ (2004) Animal models for obsessive-compulsive disorder. Current Neuropharmacology 2:169-181
38. Mataix-Cols D, Rosario-Campos MC, Leckman JF (2005) A multidimensional model of obsessive-compulsive disorder. Am J Psychiatry 162:228-238
39. Matsunaga H, Kiriike N, Matsui T, Iwasaki Y, Koshimune K, Ohya K, Stein DJ (2001) A comparative study of clinical features between pure checkers and pure washers categorized using a lifetime symptom rating method. Psychiatry Res 105:221-229
40. Mundt A, Klein J, Joel D, Heinz A, Djodari-Irani A, Harnack D, Kupsch A, Orawa H, Juckel G, Morgenstern R, Winter C (2009) High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur J Neurosci 29:2401-2412
41. Murphy DL, Zohar J, Benkelfat C, Pato MT, Pigott TA, Insel TR (1989) Obsessive-compulsive disorder as a 5-HT subsystem-related behavioural disorder. Br J Psychiatry Suppl (8):15-24
42. Noldus LP, Spink AJ, Tegelenbosch RA (2001) EthoVision: a versatile video tracking system for automation of behavioral experiments. BehavResMethods InstrumComput 33:398-414
43. Pigott TA, Hill JL, Grady TA, L'Heureux F, Bernstein S, Rubenstein CS, Murphy DL (1993) A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biol Psychiatry 33:3-14
44. Pitman RK (1989) Animal models of compulsive behavior. Biol Psychiatry 26:189-198
45. Rajkumar R, Pandey DK, Mahesh R, Radha R (2009) 1-(m-Chlorophenyl) piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT2A receptors: proposal of a modified rodent antidepressant assay. Eur J Pharmacol 608:32-41
46. Salin-Pascual RJ, Basanez-Villa E (2003) Changes in compulsion and anxiety symptoms with nicotine transdermal patches in non-smoking obsessive-compulsive disorder patients. Rev Invest Clin 55:650-654
47. Spink AJ, Tegelenbosch RA, Buma MO, Noldus LP (2001) The EthoVision video tracking system - a tool for behavioral phenotyping of transgenic mice. Physiol Behav 73:731-744
48. Szechtman H, Eilam D (2005) Psychiatric models. In: Whishaw IQ, Kolb B (eds) The behavior of the laboratory rat: a handbook with tests. Oxford University Press, New York, pp 462-474
49. Szechtman H, Woody E (2004) Obsessive-compulsive disorder as a disturbance of security motivation. Psychol Rev 111:111-127
50. Szechtman H, Sulis W, Eilam D (1998) Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 112:1475-1485
51. Szechtman H, Eckert MJ, Tse WS, Boersma JT, Bonura CA, McClelland JZ, Culver KE, Eilam D (2001) Compulsive checking behavior of quinpirole-sensitized rats as an animal model of obsessive-compulsive disorder (OCD): form and control. BMC Neurosci 2:4
52. Tizabi Y, Louis VA, Taylor CT, Waxman D, Culver KE, Szechtman H (2002) Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorder. Biol Psychiatry 51:164-171
53. Tolkamp BJ, Kyriazakis I (1999) To split behaviour into bouts, log-transform the intervals. Animal Behavior 57:807-817
54. Tolkamp BJ, Allcroft DJ, Austin EJ, Nielsen BL, Kyriazakis I (1998) Satiety splits feeding behaviour into bouts. J Theor Biol 194:235-250
55. Tsaltas E, Kontis D, Chrysikakou S, Giannou H, Biba A, Pallidi S, Christodoulou A, Maillis A, Rabavilas A (2005) Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biol Psychiatry 57:1176-1185
56. van den Heuvel OA, Remijnse PL, Mataix-Cols D, Vrenken H, Groenewegen HJ, Uylings HBM, van Balkom AJLM, Veltman DJ (2009) The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain 132:853-868
57. Westenberg HG, Fineberg NA, Denys D (2007) Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr 12:14-27
58. Whishaw IQ, Gharbawie OA, Clark BJ, Lehmann H (2006) The exploratory behavior of rats in an open environment optimizes security. Behav Brain Res 171:230-239
59. Winter C, Flash S, Klavir O, Klein J, Sohr R, Joel D (2008) The role of the subthalamic nucleus in 'compulsive' behavior in rats. Eur J Neurosci 27:1902-1911
60. Woody EZ, Szechtman H (2005) Motivation, time course, and heterogeneity in obsessive-compulsive disorder: response to Taylor, McKay, and Abramowitz (2005). Psychol Rev 112:658-661
61. Zadicario P, Ronen S, Eilam D (2007) Modulation of quinpirole-induced compulsive-like behavior in rats by environmental changes: implications for OCD rituals and for exploration and navigation. BMC Neurosci 8:23
62. Zohar J, Mueller EA, Insel TR, Zohar-Kadouch RC, Murphy DL (1987) Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Arch Gen Psychiatry 44:946-951