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Volumn 42, Issue 11, 2008, Pages 894-901

Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo

Author keywords

Cortisol; MCPP; Obsessive compulsive disorder; Prolactin; Ritanserin; Serotonin receptors

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; HYDROCORTISONE; PLACEBO; PROLACTIN; RITANSERIN; SEROTONIN 2 ANTAGONIST; SEROTONIN 2 RECEPTOR; 1-(3-CHLOROPHENYL)PIPERAZINE; DIAGNOSTIC AGENT; PIPERAZINE DERIVATIVE; SEROTONIN 2C RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

EID: 47849094106     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2007.09.001     Document Type: Article
Times cited : (27)

References (43)
  • 1
    • 0035987340 scopus 로고    scopus 로고
    • Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms
    • Abi-Saab W., Seibyl J.P., D'Souza D.C., Karper L.P., Gueorgueva R., bi-Dargham A., et al. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology (Berlin) 162 (2002) 55-62
    • (2002) Psychopharmacology (Berlin) , vol.162 , pp. 55-62
    • Abi-Saab, W.1    Seibyl, J.P.2    D'Souza, D.C.3    Karper, L.P.4    Gueorgueva, R.5    bi-Dargham, A.6
  • 3
    • 47849096248 scopus 로고    scopus 로고
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th revised ed. Washington, DC: American Psychiatric Press; 1994.
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th revised ed. Washington, DC: American Psychiatric Press; 1994.
  • 4
    • 0024359398 scopus 로고
    • Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats
    • Bagdy G., Szemeredi K., Kanyicska B., and Murphy D.L. Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats. Journal of Pharmacology and Experimental Therapeutics 250 (1989) 72-78
    • (1989) Journal of Pharmacology and Experimental Therapeutics , vol.250 , pp. 72-78
    • Bagdy, G.1    Szemeredi, K.2    Kanyicska, B.3    Murphy, D.L.4
  • 5
    • 0025184390 scopus 로고
    • Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder
    • Bastani B., Nash J.F., and Meltzer H.Y. Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. Archives of General Psychiatry 47 (1990) 833-839
    • (1990) Archives of General Psychiatry , vol.47 , pp. 833-839
    • Bastani, B.1    Nash, J.F.2    Meltzer, H.Y.3
  • 6
    • 0028863641 scopus 로고
    • The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain
    • Baumann M.H., Mash D.C., and Staley J.K. The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain. Neuroreport 6 (1995) 2150-2152
    • (1995) Neuroreport , vol.6 , pp. 2150-2152
    • Baumann, M.H.1    Mash, D.C.2    Staley, J.K.3
  • 7
    • 0030943214 scopus 로고    scopus 로고
    • Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment
    • Broocks A., Briggs N.C., Pigott T.A., Hill J.L., Canter S.K., Tolliver T.J., et al. Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment. Psychopharmacology (Berlin) 130 (1997) 91-103
    • (1997) Psychopharmacology (Berlin) , vol.130 , pp. 91-103
    • Broocks, A.1    Briggs, N.C.2    Pigott, T.A.3    Hill, J.L.4    Canter, S.K.5    Tolliver, T.J.6
  • 8
    • 0023179757 scopus 로고
    • Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects
    • Charney D.S., Woods S.W., Goodman W.K., and Heninger G.R. Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects. Psychopharmacology (Berlin) 92 (1987) 14-24
    • (1987) Psychopharmacology (Berlin) , vol.92 , pp. 14-24
    • Charney, D.S.1    Woods, S.W.2    Goodman, W.K.3    Heninger, G.R.4
  • 9
    • 0023860008 scopus 로고
    • Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects
    • Charney D.S., Goodman W.K., Price L.H., Woods S.W., Rasmussen S.A., and Heninger G.R. Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects. Archives of General Psychiatry 45 (1988) 177-185
    • (1988) Archives of General Psychiatry , vol.45 , pp. 177-185
    • Charney, D.S.1    Goodman, W.K.2    Price, L.H.3    Woods, S.W.4    Rasmussen, S.A.5    Heninger, G.R.6
  • 10
    • 0032902870 scopus 로고    scopus 로고
    • Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain
    • Eriksson E., Engberg G., Bing O., and Nissbrandt H. Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology 20 (1999) 287-296
    • (1999) Neuropsychopharmacology , vol.20 , pp. 287-296
    • Eriksson, E.1    Engberg, G.2    Bing, O.3    Nissbrandt, H.4
  • 11
    • 0035213085 scopus 로고    scopus 로고
    • Low versus standard dose mCPP challenge in obsessive-compulsive patients
    • Erzegovesi S., Martucci L., Henin M., and Bellodi L. Low versus standard dose mCPP challenge in obsessive-compulsive patients. Neuropsychopharmacology 24 (2001) 31-36
    • (2001) Neuropsychopharmacology , vol.24 , pp. 31-36
    • Erzegovesi, S.1    Martucci, L.2    Henin, M.3    Bellodi, L.4
  • 12
    • 3142727136 scopus 로고    scopus 로고
    • Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile
    • Feuchtl A., Bagli M., Stephan R., Frahnert C., Kolsch H., Kuhn K.U., et al. Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile. Pharmacopsychiatry 37 (2004) 180-188
    • (2004) Pharmacopsychiatry , vol.37 , pp. 180-188
    • Feuchtl, A.1    Bagli, M.2    Stephan, R.3    Frahnert, C.4    Kolsch, H.5    Kuhn, K.U.6
  • 13
    • 0019382706 scopus 로고
    • Serotonergic stimulation of pituitary-adrenocortical function in rats
    • Fuller R.W. Serotonergic stimulation of pituitary-adrenocortical function in rats. Neuroendocrinology 32 (1981) 118-127
    • (1981) Neuroendocrinology , vol.32 , pp. 118-127
    • Fuller, R.W.1
  • 14
    • 0038489422 scopus 로고    scopus 로고
    • Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety
    • Gatch M.B. Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life Sciences 73 (2003) 1347-1367
    • (2003) Life Sciences , vol.73 , pp. 1347-1367
    • Gatch, M.B.1
  • 17
    • 0029119856 scopus 로고
    • m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: absence of symptom exacerbation
    • Goodman W.K., McDougle C.J., Price L.H., Barr L.C., Hills O.F., Caplik J.F., et al. m-Chlorophenylpiperazine in patients with obsessive-compulsive disorder: absence of symptom exacerbation. Biological Psychiatry 38 (1995) 138-149
    • (1995) Biological Psychiatry , vol.38 , pp. 138-149
    • Goodman, W.K.1    McDougle, C.J.2    Price, L.H.3    Barr, L.C.4    Hills, O.F.5    Caplik, J.F.6
  • 18
    • 0024514089 scopus 로고
    • 1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain
    • Hamik A., and Peroutka S.J. 1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain. Biological Psychiatry 25 (1989) 569-575
    • (1989) Biological Psychiatry , vol.25 , pp. 569-575
    • Hamik, A.1    Peroutka, S.J.2
  • 19
    • 0036166909 scopus 로고    scopus 로고
    • Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis
    • Hemrick-Luecke S.K., and Evans D.C. Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. Neuropharmacology 42 (2002) 162-169
    • (2002) Neuropharmacology , vol.42 , pp. 162-169
    • Hemrick-Luecke, S.K.1    Evans, D.C.2
  • 21
    • 0026519130 scopus 로고
    • Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers
    • Hollander E., DeCaria C.M., Nitescu A., Gully R., Suckow R.F., Cooper T.B., et al. Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Archives of General Psychiatry 49 (1992) 21-28
    • (1992) Archives of General Psychiatry , vol.49 , pp. 21-28
    • Hollander, E.1    DeCaria, C.M.2    Nitescu, A.3    Gully, R.4    Suckow, R.F.5    Cooper, T.B.6
  • 23
    • 0345267247 scopus 로고    scopus 로고
    • Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive-compulsive disorder and controls
    • Ho Pian K.L., Westenberg H.G., den Boer J.A., de Bruin W.I., and van Rijk P.P. Effects of meta-chlorophenylpiperazine on cerebral blood flow in obsessive-compulsive disorder and controls. Biological Psychiatry 44 (1998) 367-370
    • (1998) Biological Psychiatry , vol.44 , pp. 367-370
    • Ho Pian, K.L.1    Westenberg, H.G.2    den Boer, J.A.3    de Bruin, W.I.4    van Rijk, P.P.5
  • 24
    • 0023895447 scopus 로고
    • Functional correlates of serotonin 5-HT1 recognition sites
    • Hoyer D. Functional correlates of serotonin 5-HT1 recognition sites. Journal of Receptor Research 8 (1988) 59-81
    • (1988) Journal of Receptor Research , vol.8 , pp. 59-81
    • Hoyer, D.1
  • 25
    • 0026353340 scopus 로고
    • m-Chlorophenylpiperazine as a probe of serotonin function
    • Kahn R.S., and Wetzler S. m-Chlorophenylpiperazine as a probe of serotonin function. Biological Psychiatry 30 (1991) 1139-1166
    • (1991) Biological Psychiatry , vol.30 , pp. 1139-1166
    • Kahn, R.S.1    Wetzler, S.2
  • 26
  • 27
    • 0025182532 scopus 로고
    • Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects
    • Kahn R.S., Kalus O., Wetzler S., Cahn W., Asnis G.M., and van Praag H.M. Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects. Psychiatry Research 33 (1990) 189-198
    • (1990) Psychiatry Research , vol.33 , pp. 189-198
    • Kahn, R.S.1    Kalus, O.2    Wetzler, S.3    Cahn, W.4    Asnis, G.M.5    van Praag, H.M.6
  • 28
    • 0035219188 scopus 로고    scopus 로고
    • Neuroendocrine and behavioral responses to mCPP in obsessive-compulsive disorder
    • Khanna S., John J.P., and Reddy L.P. Neuroendocrine and behavioral responses to mCPP in obsessive-compulsive disorder. Psychoneuroendocrinology 26 (2001) 209-223
    • (2001) Psychoneuroendocrinology , vol.26 , pp. 209-223
    • Khanna, S.1    John, J.P.2    Reddy, L.P.3
  • 29
    • 0026674018 scopus 로고
    • Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls
    • Lucey J.V., O'Keane V., Butcher G., Clare A.W., and Dinan T.G. Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls. British Journal of Psychiatry 161 (1992) 517-521
    • (1992) British Journal of Psychiatry , vol.161 , pp. 517-521
    • Lucey, J.V.1    O'Keane, V.2    Butcher, G.3    Clare, A.W.4    Dinan, T.G.5
  • 30
    • 0026592571 scopus 로고
    • Neuroendocrine and behavioral responses to challenge with the indirect serotonin agonist dl-fenfluramine in adults with obsessive-compulsive disorder
    • McBride P.A., DeMeo M.D., Sweeney J.A., Halper J., Mann J.J., and Shear M.K. Neuroendocrine and behavioral responses to challenge with the indirect serotonin agonist dl-fenfluramine in adults with obsessive-compulsive disorder. Biological Psychiatry 31 (1992) 19-34
    • (1992) Biological Psychiatry , vol.31 , pp. 19-34
    • McBride, P.A.1    DeMeo, M.D.2    Sweeney, J.A.3    Halper, J.4    Mann, J.J.5    Shear, M.K.6
  • 33
    • 0022892343 scopus 로고
    • Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans
    • Mueller E.A., Murphy D.L., and Sunderland T. Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans. Psychopharmacology (Berlin) 89 (1986) 388-391
    • (1986) Psychopharmacology (Berlin) , vol.89 , pp. 388-391
    • Mueller, E.A.1    Murphy, D.L.2    Sunderland, T.3
  • 34
    • 0024313157 scopus 로고
    • Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers
    • Murphy D.L., Mueller E.A., Hill J.L., Tolliver T.J., and Jacobsen F.M. Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers. Psychopharmacology (Berlin) 98 (1989) 275-282
    • (1989) Psychopharmacology (Berlin) , vol.98 , pp. 275-282
    • Murphy, D.L.1    Mueller, E.A.2    Hill, J.L.3    Tolliver, T.J.4    Jacobsen, F.M.5
  • 35
    • 0027458735 scopus 로고
    • A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP
    • Pigott T.A., Hill J.L., Grady T.A., L'Heureux F., Bernstein S., Rubenstein C.S., et al. A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP. Biological Psychiatry 33 (1993) 3-14
    • (1993) Biological Psychiatry , vol.33 , pp. 3-14
    • Pigott, T.A.1    Hill, J.L.2    Grady, T.A.3    L'Heureux, F.4    Bernstein, S.5    Rubenstein, C.S.6
  • 36
    • 0032858740 scopus 로고    scopus 로고
    • Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells
    • Porter R.H., Benwell K.R., Lamb H., Malcolm C.S., Allen N.H., Revell D.F., et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. British Journal of Pharmacology 128 (1999) 13-20
    • (1999) British Journal of Pharmacology , vol.128 , pp. 13-20
    • Porter, R.H.1    Benwell, K.R.2    Lamb, H.3    Malcolm, C.S.4    Allen, N.H.5    Revell, D.F.6
  • 37
    • 0036121286 scopus 로고    scopus 로고
    • Serotonin releasing agents. Neurochemical, therapeutic and adverse effects
    • Rothman R.B., and Baumann M.H. Serotonin releasing agents. Neurochemical, therapeutic and adverse effects. Pharmacology, Biochemistry and Behavior 71 (2002) 825-836
    • (2002) Pharmacology, Biochemistry and Behavior , vol.71 , pp. 825-836
    • Rothman, R.B.1    Baumann, M.H.2
  • 38
    • 0026056522 scopus 로고
    • Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects
    • Seibyl J.P., Krystal J.H., Price L.H., Woods S.W., D'Amico C., Heninger G.R., et al. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 38 (1991) 227-236
    • (1991) Psychiatry Research , vol.38 , pp. 227-236
    • Seibyl, J.P.1    Krystal, J.H.2    Price, L.H.3    Woods, S.W.4    D'Amico, C.5    Heninger, G.R.6
  • 39
    • 0028169962 scopus 로고
    • The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers
    • Silverstone P.H., and Cowen P.J. The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers. Biological Psychiatry 36 (1994) 309-316
    • (1994) Biological Psychiatry , vol.36 , pp. 309-316
    • Silverstone, P.H.1    Cowen, P.J.2
  • 41
    • 31144476933 scopus 로고    scopus 로고
    • Desensitization of 5-HT(2A) receptor function by chronic administration of selective serotonin reuptake inhibitors
    • Yamauchi M., Miyara T., Matsushima T., and Imanishi T. Desensitization of 5-HT(2A) receptor function by chronic administration of selective serotonin reuptake inhibitors. Brain Research 1067 (2006) 164-169
    • (2006) Brain Research , vol.1067 , pp. 164-169
    • Yamauchi, M.1    Miyara, T.2    Matsushima, T.3    Imanishi, T.4
  • 42
    • 0036827036 scopus 로고    scopus 로고
    • Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI
    • Zhang Y., Damjanoska K.J., Carrasco G.A., Dudas B., D'souza D.N., Tetzlaff J., et al. Evidence that 5-HT2A receptors in the hypothalamic paraventricular nucleus mediate neuroendocrine responses to (-)DOI. Journal of Neuroscience 22 (2002) 9635-9642
    • (2002) Journal of Neuroscience , vol.22 , pp. 9635-9642
    • Zhang, Y.1    Damjanoska, K.J.2    Carrasco, G.A.3    Dudas, B.4    D'souza, D.N.5    Tetzlaff, J.6
  • 43


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