Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior

Psychopharmacology

Volumn 227, Issue 1, 2013, Pages 55-66

  Schepisi, Chiara ^a   De Carolis, Lorenza ^a   Nencini, Paolo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

5HT2c receptor; Clomipramine; Contrafreeloading; Obsessive compulsive disorder; Polydipsia; Pramipexole; SB242084

Indexed keywords

6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; CLOMIPRAMINE; PRAMIPEXOLE; SEROTONIN 2C RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; COMPULSION; CONTRAFREELOADING; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG SENSITIVITY; FLUID INTAKE; FORAGING BEHAVIOR; MALE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; POLYDIPSIA; PRIORITY JOURNAL; RAT;

AMINOPYRIDINES; ANIMALS; BENZOTHIAZOLES; COMPULSIVE BEHAVIOR; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; DRINKING; INDOLES; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D3; REINFORCEMENT SCHEDULE; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS; TREATMENT OUTCOME;

EID: 84876062987     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2938-z     Document Type: Article

References (74)

1. Ahlskog JE (2011) Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease. Physiol Behav 104:168-172
2. Amato D, Milella MS, Badiani A, Nencini P (2006) Compulsive-like effects of repeated administration of quinpirole on drinking behavior in rats. Behav Brain Res 172:1-13
3. Amato D, Milella MS, Badiani A, Nencini P (2007) Compulsive-like effects of quinpirole on drinking behavior in rats are inhibited by substituting ethanol for water. Behav Brain Res 177:340-346
4. Amato D, Stasi MA, Borsini F, Nencini P (2008) Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia. Psychopharmacology 200:157-165
5. Antonini A, Barone P, Ceravolo R, Fabbrini G, Tinazzi M, Abbruzzese G (2010) Role of pramipexole in the management of Parkinson's disease. CNS Drugs 24:829-841
6. Attar-Lévy D, Martinot JL, Blin J, Dao-Castellana MH, Crouzel C, Mazoyer B, Poirier MF, Bourdel MC, Aymard N, Syrota A, Féline A (1999) The cortical serotonin2 receptors studied with positron-emission tomography and [18F]-setoperone during depressive illness and antidepressant treatment with clomipramine. Biol Psychiatry 45:180-186
7. Badiani A, Vaccaro R, Burdino R, Casini A, Valeri P, Renda TG, Nencini P (2002) Dissociation in the effects of the D2/D3 dopaminergic agonist quinpirole on drinking and on vasopressin levels in the rat. Neurosci Lett 325:79-82
8. Bienfait KL, Menza M, Mark MH, Dobkin RD (2010) Impulsive smoking in a patient with Parkinson's disease treated with dopamine agonists. J Clin Neurosci 17:539-540
9. Blier P, de Montigny C (2008) Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses. Biol Psych 44:313-323
10. Boulouguris V, Robbins TW (2010) Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. J Neurosci 30:930-938
11. Boulouguris V, Glennon JC, Robbins TW (2008) Dissociable effects of selective 5-HT2A and 5HT2C receptor antagonists on serial spatial reversal learning in rats. Neuropsychopharmacology 33:2007-2019
12. Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC (1991) Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Res 564:203-219
13. Bratcher NA, Farmer-Dougan V, Dougan JD, Heidenreich BA, Garris PA (2005) The role of dopamine in reinforcement: changes in reinforcement sensitivity induced by D1-type, D2-type, and nonselective dopamine receptor agonists. J Exp Anal Behav 84:371-399
14. Campbell-Meiklejohn D, Wakeley J, Herbert V, Cook J, Scollo P, Ray MK, Selvaraj S, Passingham RE, Cowen P, Rogers RD (2011) Serotonin and dopamine play complementary roles in gambling to recover losses. Neuropsychopharmacology 36:402-410
15. Chang WL, Geyer MA, Buell MR, Weber M, Swerdlow NR (2010) The effects of pramipexole on prepulse inhibition and locomotor activity in C57BL/6J mice. Behav Pharmacol 21:135-143
16. Chang WL, Breier MR, Yang A, Swerdlow NR (2011) Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats. Pharmacol Biochem Behav 99:634-638
17. Chang WL, Weber M, Breier MR, Saint Marie RL, Hines SR, Swerdlow NR (2012) Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats. Brain Res 1437:69-76
18. Chernoloz O, El Mansari M, Blier P (2009) Sustained administration of pramipexole modifies the spontaneous firing of dopamine, norepinephrine, and serotonin neurons in the rat brain. Neuropsychopharmacology 34:651-661
19. Cioli I, Caricati A, Nencini P (2000) Quinpirole- and amphetamine-induced hyperdipsia: influence of fluid palatability and behavioral cost. Behav Brain Res 109:9-18
20. Comella CL (2002) Restless legs syndrome: treatment with dopaminergic agents. Neurology 58:S87-S92
21. De Carolis L, Stasi MA, Serlupi-Crescenzi O, Borsini F, Nencini P (2010) The effects of clozapine on quinpirole-induced non-regulatory drinking and prepulse inhibition disruption in rats. Psychopharmacology (Berl) 212:105-115
22. De Carolis L, Schepisi C, Milella MS, Nencini P (2011) Clomipramine, but not haloperidol or aripiprazole, inhibits quinpirole-induced water contrafreeloading, a putative animal model of compulsive behavior. Psychopharmacology (Berl) 218:749-759
23. de Leeuw AS, Westenberg HG (2008) Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo. J Psychiatr Res 42:894-901
24. de Leon (2003) Polydipsia - a study in a long-term psychiatric unit. Eur Arch Psychiatry Clin Neurosci 253:37-39
25. de Leon J, Verghese C, Tracy JI, Josiassen RC, Simpson GM (1994) Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature. Biol Psychiatry 35:408-419
26. Deas-Nesmith D, Brewerton TD (1992) A case of fluoxetine-responsive psychogenic polydipsia: a variant of obsessive-compulsive disorder? J Nerv Ment Dis 180:338-339
27. Diaz J, Levesque D, Lammers CH, Griffon N, Martres MP, Schwartz JC, Sokoloff P (1995) Phenotypical characterization of neurons expressing the dopamine D3 receptor in rat brain. Neuroscience 65:731-745
28. Diaz MR, Chappell AM, Christian DT, Anderson NJ, McCool BA (2011) Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala. Neuropsychopharmacology 36:1090-1103
29. Dodd ML, Klos KJ, Bower JH, Geda YE, Josephs KA, Ahiskog JE (2005) Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol 62:1377-1381
30. Fineberg NA, Gale TM (2005) Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int J Neuropsychopharmacol 8:107-129
31. Fleischer-Grinberg S, Klavir O, Joel D (2008) The role of 5HT2A and 5HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. Int J Neuropsychopharmacol 11:811-825
32. Fox SH, Katzenschlager R, Lim SY, Ravina B, Seppi K, Coelho M, Poewe W, Rascol O, Goetz CG, Sampaio C (2011) The movement disorder society evidence-based medicine review update: treatments for the motor symptoms of Parkinson's disease. Mov Disord 3:S2-S41
33. Fraioli S, Cioli I, Nencini P (1997) Amphetamine reinstates polydipsia induced by chronic exposure to quinpirole, a dopaminergic D2 agonist, in rats. Behav Brain Res 89:199-215
34. Greene-Schloesser DM, Van der Zee EA, Sheppard DK, Castillo MR, Gregg KA, Burrow T, Foltz H, Slater M, Bult-Ito A (2011) Predictive validity of a non-induced mouse model of compulsive-like behavior. Behav Brain Res 221:55-62
35. Hassan A, Bower JH, Kumar N, Matsumoto JY, Fealey RD, Josephs KA, Ahlskog JE (2011) Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies. Parkinsonism Relat Disord 17:260-264
36. Inglis IR, Ferguson NJ (1986) Starlings search for food rather than eat freely-available, identical food. Anim Behav 34:614-617
37. Inglis IR, Forkman B, Lazarus J (1997) Free food or earned food? A review and fuzzy model of contrafreeloading. Anim Behav 53:1171-1191
38. Jensen ED (1963) Preference for bar pressing over "free- loading" as a function of unrewarded presses. J Exp Psychol 65:451-454
39. Joel D, Avisar A (2001) Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder? Behav Brain Res 123:77-87
40. Johnson PS, Madden GJ, Brewer AT, Pinkston JW, Fowler SC (2011) Effects of acute pramipexole on preference for gambling-like schedules of reinforcement in rats. Psychopharmacology (Berl):11-18
41. Kolla BP, Mansukhani MP, Barraza R, Bostwick JM (2010) Impact of dopamine agonists on compulsive behaviors: a case series of pramipexole-induced pathological gambling. Psychosomatics 51:271-273
42. Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB, American Psychiatric Association (2007) Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry 164:5-53
43. Kurylo DD (2004) Effects of quinpirole on operant conditioning: perseveration of behavioral components. Behav Brain Res 155:117-124
44. Kvernmo T, Härtter S, Bürger E (2006) A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther 28:1065-1078
45. Lader M (2008) Antiparkinsonian medication and pathological gambling. CNS Drugs 22:407-416
46. Leggio GM, Cathala A, Moison D, Cunningham KA, Piazza PV, Spampinato U (2009) Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens. Neuropharmacology 56:507-513
47. Levant B (1998) Differential distribution of D3 dopamine receptors in the brains of several mammalian species. Brain Res 800:269-274
48. Levesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (1992) Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxyl-N, N-di-n-propyl-2-aminotetralin. Proc Natl Acad Sci USA 89:815
49. Li X, Morrow D, Witkin JM (2006) Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying. Life Sci 78(17):1933-1939
50. Manconi M, Ferri R, Zucconi M, Clemens S, Giarolli L, Bottasini V, Ferini-Strambi L (2011) Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. Neurology 77:110-117
51. McGowan RT, Robbins CT, Alldredge JR, Newberry RC (2010) Contrafreeloading in grizzly bears: implications for captive foraging enrichment. Zoo Biol 29:484-502
52. Mierau J, Schneider FJ, Ensinger HA, Chio CL, Lajiness ME, Huff RM (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol 290:29-36
53. Milella MS, Amato D, Badiani A, Nencini P (2008) The influence of cost manipulation on water contrafreeloading induced by repeated exposure to quinpirole in the rat. Psychopharmacology 197:379-390
54. Milella MS, Passarelli F, De Carolis L, Schepisi C, Nativio P, Scaccianoce S, Nencini P (2010) Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia. Psychopharmacology (Berl) 211:355-366
55. Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther 303:791-804
56. Navailles S, Moison D, Cunningham KA, Spampinato U (2008) Differential regulation of the mesoaccumbens dopamine circuit by serotonin2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology 33:237-246
57. Nirenberg MJ, Waters C (2006) Compulsive eating and weight gain related to dopamine agonist use. Mov Disord 21:524-529
58. Ogura T (2011) Contrafreeloading and the value of control over visual stimuli in Japanese macaques (Macaca fuscata). Anim Cogn 14:427-431
59. Pittenger C (2011) Pathophysiological modeling of obsessive-compulsive disorder: challenges, and progress. Biol Psychiatry 70:1002-1003
60. Rendell M, McGrane D, Cuesta M (1978) Fatal compulsive water drinking. JAMA 240:2557-2559
61. Riba J, Krämer UM, Heldmann M, Richter S, Münte TF (2008) Dopamine agonist increases risk taking but blunts reward-related brain activity. PLoS One 3:e2479
62. Robertson LC, Anderson SC (1975) The effects of differing type and magnitude of reward on the contrafreeloading phenomenon in rats. Anim Learn Behav 3:325-328
63. Schilman EA, Klavir O, Winter C, Sohr R, Joel D (2010) The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system. Neuropsychopharmacology 35:1026-1039
64. Serretti A, Artioli P, De Ronchi D (2004) The 5HT2C receptor as a target for mood disorders. Expert Opin Ther Targets 8:15-23
65. Shanahan NA, Velez LP, Masten VL, Dulawa SC (2011) Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biol Psychiatry 70:1039-1048
66. Shutty MS Jr, McCulley K, Pigott B (1995) Association between stereotypic behavior and polydipsia in chronic schizophrenic patients. J Behav Ther Exp Psychiatry 26:339-343
67. Simpson HB (2010) Pharmacological treatment of obsessive-compulsive disorder. Curr Top Behav Neurosci 2:527-543
68. Singh D (1970) Preference for bar pressing to obtain reward over freeloading in rats and children. J Comp Physiol Psychol 73:320-327
69. Sotty F, Folgering JH, Hogg S, Mork A, Hertel P, Cremers TI (2009) Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRI effects. Neuropharmacology 57:18-24
70. Szechtman H, Sulis W, Eilam D (1998) Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 112:1475-1485
71. Tarte RD (1981) Contrafreeloading in humans. Psychol Rep 49:859-866
72. van Eimeren T, Ballanger B, Pellecchia G, Miyasaki JM, Lang AE, Strafella AP (2009) Dopamine agonists diminish value sensitivity of the orbitofrontal cortex: a trigger for pathological gambling in Parkinson's disease? Neuropsychopharmacology 34:2758-2766
73. Yamauchi M, Tatebayashi T, Nagase K, Kojima M, Imanishi T (2004) Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats. Pharmacol Biochem Behav 78:683-689
74. Ye Z, Hammer A, Camara E, Münte TF (2011) Pramipexole modulates the neural network of reward anticipation. Hum Brain Mapp 32:800-811