-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: The next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
77950346282
-
Immunity, inflammation, and cancer
-
S.I. Grivennikov et al. Immunity, inflammation, and cancer Cell 140 2010 883 899
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
-
3
-
-
79952193038
-
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
-
W. Tan et al. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling Nature 470 2011 548 553
-
(2011)
Nature
, vol.470
, pp. 548-553
-
-
Tan, W.1
-
4
-
-
79953761842
-
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
-
A. Fukuda et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression Cancer Cell 19 2011 441 455
-
(2011)
Cancer Cell
, vol.19
, pp. 441-455
-
-
Fukuda, A.1
-
5
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
M. Lesina et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer Cancer Cell 19 2011 456 469
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
-
6
-
-
79953749145
-
The unholy trinity: Inflammation, cytokines, and STAT3 shape the cancer microenvironment
-
N. Li et al. The unholy trinity: Inflammation, cytokines, and STAT3 shape the cancer microenvironment Cancer Cell 19 2011 429 431
-
(2011)
Cancer Cell
, vol.19
, pp. 429-431
-
-
Li, N.1
-
7
-
-
0030963446
-
Positional cloning of the gene for multiple endocrine neoplasia-type 1
-
S.C. Chandrasekharappa et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1 Science 276 1997 404 407
-
(1997)
Science
, vol.276
, pp. 404-407
-
-
Chandrasekharappa, S.C.1
-
8
-
-
0141457540
-
Functional characterization of a promoter region in the human MEN1 tumor suppressor gene
-
M. Fromaget et al. Functional characterization of a promoter region in the human MEN1 tumor suppressor gene J. Mol. Biol. 333 2003 87 102
-
(2003)
J. Mol. Biol.
, vol.333
, pp. 87-102
-
-
Fromaget, M.1
-
10
-
-
0034055408
-
Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues
-
V. Wautot et al. Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues Int. J. Cancer 85 2000 877 881
-
(2000)
Int. J. Cancer
, vol.85
, pp. 877-881
-
-
Wautot, V.1
-
11
-
-
0033592706
-
Stable overexpression of MEN1 suppresses tumorigenicity of RAS
-
Y.S. Kim et al. Stable overexpression of MEN1 suppresses tumorigenicity of RAS Oncogene 18 1999 5936 5942
-
(1999)
Oncogene
, vol.18
, pp. 5936-5942
-
-
Kim, Y.S.1
-
12
-
-
0032539632
-
Menin, the product of the MEN1 gene, is a nuclear protein
-
S.C. Guru et al. Menin, the product of the MEN1 gene, is a nuclear protein Proc. Natl. Acad. Sci. USA 95 1998 1630 1634
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1630-1634
-
-
Guru, S.C.1
-
13
-
-
0141885136
-
Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex
-
H. Kim et al. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex Cancer Res. 63 2003 6135 6139
-
(2003)
Cancer Res.
, vol.63
, pp. 6135-6139
-
-
Kim, H.1
-
14
-
-
84876902432
-
Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome
-
B. Gurung et al. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome Cancer Res. 73 2013 2650 2658
-
(2013)
Cancer Res.
, vol.73
, pp. 2650-2658
-
-
Gurung, B.1
-
15
-
-
70450227256
-
Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin
-
S.B. Gao et al. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin Oncogene 28 2009 4095 4104
-
(2009)
Oncogene
, vol.28
, pp. 4095-4104
-
-
Gao, S.B.1
-
16
-
-
84879728552
-
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation
-
Y.J. Yang, T.Y. Song, J. Park, and J. Lee et al. Menin mediates epigenetic regulation via histone H3 lysine 9 methylation Cell Death Dis. 4 2013 583
-
(2013)
Cell Death Dis.
, vol.4
, pp. 583
-
-
Yang, Y.J.1
Song, T.Y.2
Park, J.3
Lee, J.4
-
17
-
-
20044380143
-
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
-
T.A. Milne et al. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Proc. Natl. Acad. Sci. USA 102 2005 749 754
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 749-754
-
-
Milne, T.A.1
-
18
-
-
26844548626
-
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27(Kip1) and p18(INK4c)
-
S.K. Karnik et al. Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27(Kip1) and p18(INK4c) Proc. Natl. Acad. Sci. USA 102 2005 14659 14664
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14659-14664
-
-
Karnik, S.K.1
-
19
-
-
10744224167
-
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
-
C.M. Hughes et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus Mol. Cell 13 2004 587 597
-
(2004)
Mol. Cell
, vol.13
, pp. 587-597
-
-
Hughes, C.M.1
-
20
-
-
84890030905
-
Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model
-
R.K. Ng et al. Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model J. Pathol. 232 2014 65 74
-
(2014)
J. Pathol.
, vol.232
, pp. 65-74
-
-
Ng, R.K.1
-
21
-
-
84862777931
-
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
-
J. Huang et al. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription Nature 482 2012 542 546
-
(2012)
Nature
, vol.482
, pp. 542-546
-
-
Huang, J.1
-
22
-
-
32244439095
-
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
-
Y.X. Chen et al. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression Proc. Natl. Acad. Sci. USA 103 2006 1018 1023
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 1018-1023
-
-
Chen, Y.X.1
-
23
-
-
26844555530
-
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
-
A. Yokoyama et al. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis Cell 123 2005 207 218
-
(2005)
Cell
, vol.123
, pp. 207-218
-
-
Yokoyama, A.1
-
24
-
-
84886412528
-
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription
-
B. Xu et al. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription Proc. Natl. Acad. Sci. USA 110 2013 17480 17485
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 17480-17485
-
-
Xu, B.1
-
25
-
-
33751009660
-
Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis
-
P.J. Zindy et al. Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis Hepatology 44 2006 1296 1307
-
(2006)
Hepatology
, vol.44
, pp. 1296-1307
-
-
Zindy, P.J.1
-
26
-
-
0031963046
-
The pathophysiologic roles of interleukin-6 in human disease
-
D.A. Papanicolaou et al. The pathophysiologic roles of interleukin-6 in human disease Ann. Intern. Med. 128 1998 127 137
-
(1998)
Ann. Intern. Med.
, vol.128
, pp. 127-137
-
-
Papanicolaou, D.A.1
-
27
-
-
0034658541
-
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
-
T. Hirano, K. Ishihara, and M. Hibi Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors Oncogene 19 2000 2548 2556
-
(2000)
Oncogene
, vol.19
, pp. 2548-2556
-
-
Hirano, T.1
Ishihara, K.2
Hibi, M.3
-
28
-
-
0033963825
-
Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene
-
A.C. Gao, W. Lou, and J.T. Isaacs Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene Clin. Cancer Res. 6 2000 493 497
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 493-497
-
-
Gao, A.C.1
Lou, W.2
Isaacs, J.T.3
-
29
-
-
33745125712
-
Tumor suppressor menin: The essential role of nuclear localization signal domains in coordinating gene expression
-
P. La, A. Desmond, Z. Hou, A.C. Silva, R.W. Schnepp, and X. Hua Tumor suppressor menin: The essential role of nuclear localization signal domains in coordinating gene expression Oncogene 25 2006 3537 3546
-
(2006)
Oncogene
, vol.25
, pp. 3537-3546
-
-
La, P.1
Desmond, A.2
Hou, Z.3
Silva, A.C.4
Schnepp, R.W.5
Hua, X.6
-
30
-
-
45849115106
-
Menin critically links MLL proteins with LEDGF on cancer-associated target genes
-
A. Yokoyama, and M.L. Cleary Menin critically links MLL proteins with LEDGF on cancer-associated target genes Cancer Cell 14 2008 36 46
-
(2008)
Cancer Cell
, vol.14
, pp. 36-46
-
-
Yokoyama, A.1
Cleary, M.L.2
-
31
-
-
0035816682
-
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
-
M. Tachibana, K. Sugimoto, T. Fukushima, and Y. Shinkai Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3 J. Biol. Chem. 276 2001 25309 25317
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25309-25317
-
-
Tachibana, M.1
Sugimoto, K.2
Fukushima, T.3
Shinkai, Y.4
-
32
-
-
0034632829
-
Regulation of chromatin structure by site-specific histone H3 methyltransferases
-
S. Rea et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases Nature 406 2000 593 599
-
(2000)
Nature
, vol.406
, pp. 593-599
-
-
Rea, S.1
-
33
-
-
0034461595
-
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
-
D. O'Carroll et al. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression Mol. Cell. Biol. 20 2000 9423 9433
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9423-9433
-
-
O'carroll, D.1
-
34
-
-
84872033208
-
G9a, a multipotent regulator of gene expression
-
S.R. Shankar et al. G9a, a multipotent regulator of gene expression Epigenetics 8 2013 16 22
-
(2013)
Epigenetics
, vol.8
, pp. 16-22
-
-
Shankar, S.R.1
-
35
-
-
84880721384
-
Menin: A scaffold protein that controls gene expression and cell signaling
-
S. Matkar, A. Thiel, and X. Hua Menin: A scaffold protein that controls gene expression and cell signaling Trends Biochem. Sci. 38 2013 394 402
-
(2013)
Trends Biochem. Sci.
, vol.38
, pp. 394-402
-
-
Matkar, S.1
Thiel, A.2
Hua, X.3
-
36
-
-
14144256749
-
Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes
-
N. Mizusawa et al. Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes Gene 331 2004 53 63
-
(2004)
Gene
, vol.331
, pp. 53-63
-
-
Mizusawa, N.1
-
37
-
-
0037180757
-
Inflammation and cancer
-
L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
38
-
-
84886002334
-
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
-
Y. Zhang et al. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance Cancer Res. 73 2013 6359 6374
-
(2013)
Cancer Res.
, vol.73
, pp. 6359-6374
-
-
Zhang, Y.1
-
39
-
-
84906935030
-
Inflammation and pancreatic cancer: Tale of two cytokines
-
Wei. Li et al. Inflammation and pancreatic cancer: Tale of two cytokines Cell Biol. Res. Therapy 10 2012 2324 9293
-
(2012)
Cell Biol. Res. Therapy
, vol.10
, pp. 2324-9293
-
-
Li, W.1
-
40
-
-
77952315859
-
Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
-
C. Huang et al. Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro J. Exp. Clin. Cancer Res. 29 2010 51
-
(2010)
J. Exp. Clin. Cancer Res.
, vol.29
, pp. 51
-
-
Huang, C.1
|