Functional characterization of a promoter region in the human MEN1 tumor suppressor gene

Journal of Molecular Biology

Volumn 333, Issue 1, 2003, Pages 87-102

  Fromaget, Maud ^a   Vercherat, Cécile ^a   Zhang, Chang X ^b   Zablewska, Barbara ^c   Gaudray, Patrick ^c   Chayvialle, Jean Alain ^a   Calender, Alain ^a,d   Cordier Bussat, Martine ^a  

^a INSERM   (France)

^b CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^c CNRS   (France)

^d EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Endocrine; MEN1; Menin; Promoter; TATA less

Indexed keywords

LUCIFERASE; METHIONINE; TUMOR SUPPRESSOR PROTEIN;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL HETEROGENEITY; CONTROLLED STUDY; DNA FLANKING REGION; DOWNSTREAM PROCESSING; ENDOCRINE CELL; EXON; FIBROBLAST; GENE CONTROL; GENE DELETION; GENE ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KIDNEY; KNOCKOUT MOUSE; MOLECULAR CLONING; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION SITE; TUMOR SUPPRESSOR GENE;

EID: 0141457540     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.08.001     Document Type: Article

References (29)

1. Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 276:1997;404-407.
2. Lemmens I., Van de Ven W.J., Kas K., Zhang C.X., Giraud S., Wautot V., et al. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum. Mol. Genet. 6:1997;1177-1183.
3. Larsson C., Skogseid B., Oberg K., Nakamura Y., Nordenskjold M. Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature. 332:1988;85-87.
4. Pannett A.A., Thakker R.V. Multiple endocrine neoplasia type 1. Endocr. Relat. Cancer. 6:1999;449-473.
5. Wautot V., Vercherat C., Lespinasse J., Chambe B., Lenoir G.M., Zhang C.X., et al. Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. Hum. Mutat. 20:2002;35-47.
6. Guru S.C., Goldsmith P.K., Burns A.L., Marx S.J., Spiegel A.M., Collins F.S., Chandrasekharappa S.C. Menin, the product of the MEN1 gene, is a nuclear protein. Proc. Natl Acad. Sci. USA. 95:1998;1630-1634.
7. Poisson A., Zablewska B., Gaudray P. Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1. Cancer Letters. 189:2003;1-10.
8. Crabtree J.S., Scacheri P.C., Ward J.M., Garrett-Beal L., Emmert-Buck M.R., Edgemon K.A., et al. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc. Natl Acad. Sci. USA. 98:2001;1118-1123.
9. Guru S.C., Crabtree J.S., Brown K.D., Dunn K.J., Manickam P., Prasad N.B., et al. Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene. Mamm. Genome. 10:1999;592-596.
10. Stewart C., Parente F., Piehl F., Farnebo F., Quincey D., Silins G., et al. Characterization of the mouse Men1 gene and its expression during development. Oncogene. 17:1998;2485-2493.
11. Ikeo Y., Sakurai A., Suzuki R., Zhang M.X., Koizumi S., Takeuchi Y., et al. Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage. Lab. Invest. 80:2000;797-804.
12. Farnebo F., Kytola S., Teh B.T., Dwight T., Wong F.K., Hoog A., et al. Alternative genetic pathways in parathyroid tumorigenesis. J. Clin. Endocrinol. Metab. 84:1999;3775-3780.
13. Ikeo, Y., Sakurai, A., Hashizume, K. (1999). Characterization of the MEN1 gene product, menin, by site-specific polyclonal antibodies. Jpn. J. Cancer Res. 90, 1088-95.
14. Kaji H., Canaff L., Goltzman D., Hendy G.N. Cell cycle regulation of menin expression. Cancer Res. 59:1999;5097-5101.
15. Wautot V., Khodaei S., Frappart L., Buisson N., Baro E., Lenoir G.M., et al. Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues. Int. J. Cancer. 85:2000;877-881.
16. Khodaei-O'Brien S., Zablewska B., Fromaget M., Bylund L., Weber G., Gaudray P. Heterogeneity at the 5′-end of MEN1 transcripts. Biochem. Biophys. Res. Commun. 276:2000;508-514.
17. Newton D.C., Bevan S.C., Choi S., Robb G.B., Millar A., Wang Y., Marsden P.A. Translational regulation of human neuronal nitric-oxide synthase by an alternatively spliced 5′-untranslated region leader exon. J. Biol. Chem. 278:2003;636-644.
18. Hampsey M. Molecular genetics of the RNA polymerase II general transcriptional machinery. Microbiol. Mol. Biol. Rev. 62:1998;465-503.
19. Smale S.T. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. Biochim. Biophys. Acta. 1351:1997;73-88.
20. Wang Y., Newton D.C., Robb G.B., Kau C.L., Miller T.L., Cheung A.H., et al. RNA diversity has profound effects on the translation of neuronal nitric oxide synthase. Proc. Natl Acad. Sci. USA. 96:1999;12150-12155.
21. Ahn A.H., Kunkel L.M. The structural and functional diversity of dystrophin. Nature Genet. 3:1993;283-291.
22. Muhlethaler-Mottet A., Otten L.A., Steimle V., Mach B. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:1997;2851-2860.
23. Emami K.H., Burke T.W., Smale S.T. Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. Nucl. Acids Res. 26:1998;839-846.
24. Mantovani R. A survey of 178 NF-Y binding CCAAT boxes. Nucl. Acids Res. 26:1998;1135-1143.
25. Sayo Y., Murao K., Imachi H., Cao W.M., Sato M., Dobashi H., et al. The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Endocrinology. 143:2002;2437-2440.
26. Namihira H., Sato M., Murao K., Cao W.M., Matsubara S., Imachi H., et al. The multiple endocrine neoplasia type 1 gene product, menin, inhibits the human prolactin promoter activity. J. Mol. Endocrinol. 29:2002;297-304.
27. Wang H., Maechler P., Ritz-Laser B., Hagenfeldt K.A., Ishihara H., Philippe J., Wollheim C.B. Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J. Biol. Chem. 276:2001;25279-25286.
28. Bertolino P., Radovanovic I., Casse H., Aguzzi A., Wang Z.Q., Zhang C.X. Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech. Dev. 120:2003;549-560.
29. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd edit. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.