Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4759-4769

  Zachariassen, Zack G ^a   Thiele, Stefanie ^b   Berg, Erik A ^c   Rasmussen, Pernille ^c   Fossen, Torgils ^c   Rosenkilde, Mette M ^b   Våbenø, Jon ^a   Haug, Bengt Erik ^c  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

CXCR4 antagonist; Cyclopentapeptide; Peptidomimetic; Scaffold

Indexed keywords

1,10 [[8 [2 (NAPHTHALEN 2 YL)ETHYL] 4,7 DIOXOHEXAHYDRO 2H,6H PYRAZINO[2,1 B][1,3]THIAZINE 3,6 DIYL]BIS(PROPANE 3,1 DIYL)]DIGUANIDINE; 2 GUANIDINO N [6 (3 GUANIDINOPROPYL) 8 [2 (NAPHTHALEN 2 YL)ETHYL] 4,7 DIOXOHEXAHYDRO 2H,6H PYRAZINO[2,1 B][1,3]THIAZIN 3 YL]ACETAMIDE; 5 GUANIDINO 2 (5 GUANIDINOPENTANAMIDO) N [2 (NAPHTHALEN 2 YL)ETHYL]PENTANAMIDE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; CXCR4 PROTEIN, HUMAN; CYCLOPEPTIDE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906935431     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.004     Document Type: Article

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