Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-S N2′ reactions and their use in the preparation of low-molecule CXCR4 antagonists

Journal of Organic Chemistry

Volumn 71, Issue 10, 2006, Pages 3942-3951

  Niida, Ayumu ^a   Tanigaki, Hiroaki ^a   Inokuchi, Eriko ^a   Sasaki, Yoshikazu ^a   Oishi, Shinya ^a   Ohno, Hiroaki ^a   Tamamura, Hirokazu ^a   Wang, Zixuan ^b   Peiper, Stephen C ^b   Kitaura, Kazuo ^a   Otaka, Akira ^a,c   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,6-DISUBSTITUTED-3,6-DIHYDROPYRIDIN-2-ONES; DIKETOPIPERAZINE MIMETICS; RING-CLOSING METATHESIS; STEREOSELECTIVE SYNTHESIS;

AMINO ACIDS; MOLECULAR DYNAMICS; PHOSPHATES; REACTION KINETICS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

KETONES;

3,6 DIHYDROPYRIDIN 2 ONE DERIVATIVE; ALCOHOL DERIVATIVE; ALLYL COMPOUND; ALPHA AMINO ACID; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; COPPER DERIVATIVE; DIHYDROPYRIDINE DERIVATIVE; LITHIUM CHLORIDE; ORGANOMETALLIC COMPOUND; PHOSPHATE; PIPERAZINE DERIVATIVE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; METAL BINDING; MOLECULAR WEIGHT; REACTION ANALYSIS; RING CLOSING METATHESIS; STEREOCHEMISTRY; SUBSTITUTION REACTION; SYNTHESIS;

COPPER; DIKETOPIPERAZINES; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDINES; RECEPTORS, CXCR4;

EID: 33646511988     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo060390t     Document Type: Article

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