Pharmacophore-based small molecule CXCR4 ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4169-4172

  Narumi, Tetsuo ^a   Tanaka, Tomohiro ^a   Hashimoto, Chie ^a   Nomura, Wataru ^a   Aikawa, Haruo ^a   Sohma, Akira ^a   Itotani, Kyoko ^a   Kawamata, Miyako ^b   Murakami, Tsutomu ^b   Yamamoto, Naoki ^c   Tamamura, Hirokazu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

AIDS; Chemokine receptor; HIV entry inhibitors; Low molecular weight CXCR4 ligands

Indexed keywords

ANTIVIRUS AGENT; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; ST 34; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE; HIV-1; HUMANS; LIGANDS; OLIGOPEPTIDES; RECEPTORS, CXCR4; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 84861578002     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.032     Document Type: Article

References (32)

1. T. Nagasawa, H. Kikutani, and T. Kishimoto Proc. Natl. Acad. Sci. U. S. A. 91 1994 2305
2. C.C. Bleul, M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T.A. Springer Nature 382 1996 829
3. E. Oberlin, A. Amara, F. Bachelerie, C. Bessia, J.L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.M. Heard, I. Clark-Lewis, D.L. Legler, M. Loetscher, M. Baggiolini, and B. Moser Nature 382 1996 833
4. K. Tashiro, H. Tada, R. Heilker, M. Shirozu, T. Nakano, and T. Honjo Science 261 1993 600
5. C.C. Bleul, R.C. Fuhlbrigge, J.M. Casanovas, A. Aiuti, and T.A. Springer J. Exp. Med. 2 1996 1101
6. K. Tachibana, S. Hirota, H. Iizasa, H. Yoshida, K. Kawabata, Y. Kataoka, Y. Kitamura, K. Matsushima, N. Yoshida, S. Nishikawa, T. Kishimoto, and T. Nagasawa Nature 393 1998 591
7. T. Nagasawa, S. Hirota, K. Tachibana, N. Takakura, S. Nishikawa, Y. Kitamura, N. Yoshida, H. Kikutani, and T. Kishimoto Nature 382 1996 635
8. Y. Zhu, Y. Yu, X.C. Zhang, T. Nagasawa, J.Y. Wu, and Y. Rao Nat. Neurosci. 5 2002 719
9. R.K. Stumm, C. Zhou, T. Ara, F. Lazarini, M. Dubois-Dalcq, T. Nagasawa, V. Hollt, and S. Schulz J. Neurosci. 23 2003 5123
10. H.K. Deng, R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P.D. Marzio, S. Marmon, R.E. Sutton, C.M. Hill, C.B. Davis, S.C. Peiper, T.J. Schall, D.R. Littman, and N.R. Landau Nature 381 1996 661
11. Y. Feng, C.C. Broder, P.E. Kennedy, and E.A. Berger Science 272 1996 872
12. T. Koshiba, R. Hosotani, Y. Miyamoto, J. Ida, S. Tsuji, S. Nakajima, M. Kawaguchi, H. Kobayashi, R. Doi, T. Hori, N. Fujii, and M. Imamura Clin. Cancer. Res. 6 2000 3530
13. A. Müller, B. Homey, H. Soto, N. Ge, D. Catron, M.E. Buchanan, T. McClanahan, E. Murphy, W. Yuan, S.N. Wagner, J.L. Barrera, A. Mohar, E. Verastegui, and A. Zlotnik Nature 410 2001 50
14. H. Tamamura, A. Hori, N. Kanzaki, K. Hiramatsu, M. Mizumoto, H. Nakashima, N. Yamamoto, A. Otaka, and N. Fujii FEBS Lett. 550 2003 79
15. N. Tsukada, J.A. Burger, N.J. Zvaifler, and T.J. Kipps Blood 99 2002 1030
16. J. Juarez, K.F. Bradstock, D.J. Gottlieb, and L.J. Bendall Leukemia 17 2003 1294
17. T. Nanki, K. Hayashida, H.S. EI-Gabalawy, S. Suson, K. Shi, H.J. Girschick, S. Yavuz, and P.E. Lipsky J. Immunol. 165 2000 6590
18. H. Tamamura, M. Fujisawa, K. Hiramatsu, M. Mizumoto, H. Nakashima, N. Yamamoto, A. Otaka, and N. Fujii FEBS Lett. 569 2004 99
19. T. Murakami, T. Nakajima, Y. Koyanagi, K. Tachibana, N. Fujii, H. Tamamura, N. Toshida, M. Waki, A. Matsumoto, O. Yoshie, T. Kishimoto, N. Yamamoto, and T. Nagasawa J. Exp. Med. 186 1997 1389
20. H. Tamamura, Y. Xu, T. Hattori, X. Zhang, R. Arakaki, K. Kanbara, A. Omagari, A. Otaka, T. Ibuka, N. Yamamoto, H. Nakashima, and N. Fujii Biochem. Biophys. Res. Commun. 253 1998 877
21. H. Tamamura, A. Omagari, S. Oishi, T. Kanamoto, N. Yamamoto, S.C. Peiper, H. Nakashima, A. Otaka, and N. Fujii Bioorg. Med. Chem. Lett. 10 2000 2633
22. N. Fujii, S. Oishi, K. Hiramatsu, T. Araki, S. Ueda, H. Tamamura, A. Otaka, S. Kusano, S. Terakubo, H. Nakashima, J.A. Broach, J.O. Trent, Z. Wang, and S.C. Peiper Angew. Chem., Int. Ed. 42 2003 3251
23. H. Tamamura, K. Hiramatsu, S. Ueda, Z. Wang, S. Kusano, S. Terakubo, J.O. Trent, S.C. Peiper, N. Yamamoto, H. Nakashima, A. Otaka, and N. Fujii J. Med. Chem. 48 2005 380
24. H. Tamamura, T. Araki, S. Ueda, Z. Wang, S. Oishi, A. Esaka, J.O. Trent, H. Nakashima, N. Yamamoto, S.C. Peiper, A. Otaka, and N. Fujii J. Med. Chem. 48 2005 3280
25. C. Hashimoto, T. Tanaka, T. Narumi, W. Nomura, and H. Tamamura Expert Opin. Drug Disc. 6 2011 1067
26. H. Tamamura, H. Tsutsumi, H. Masuno, S. Mizokami, K. Hiramatsu, Z. Wang, J.O. Trent, H. Nakashima, N. Yamamoto, S.C. Peiper, and N. Fujii Org. Biomol. Chem. 4 2006 2354
27. D. Schols, S. Struyf, J. Van Damme, J.A. Este, G. Henson, and E. DeClarcq J. Exp. Med. 186 1997 1383
28. K. Ichiyama, S. Yokoyama-Kumakura, Y. Tanaka, R. Tanaka, K. Hirose, K. Bannai, T. Edamatsu, M. Yanaka, Y. Niitani, N. Miyano-Kurosaki, H. Takaku, Y. Koyanagi, and N. Yamamoto Proc. Natl. Acad. Sci. U.S.A. 100 2003 4185
29. H. Tamamura, A. Ojida, T. Ogawa, H. Tsutsumi, H. Masuno, H. Nakashima, N. Yamamoto, I. Hamachi, and N. Fujii J. Med. Chem. 49 2006 3412
30. T. Tanaka, T. Narumi, T. Ozaki, A. Sohma, N. Ohashi, C. Hashimoto, K. Itotani, W. Nomura, T. Murakami, N. Yamamoto, and H. Tamamura ChemMedChem 6 2011 834
31. T. Tanaka, H. Tsutsumi, W. Nomura, Y. Tanabe, N. Ohashi, A. Esaka, C. Ochiai, J. Sato, K. Itotani, T. Murakami, K. Ohba, N. Yamamoto, N. Fujii, and H. Tamamura Org. Biomol. Chem. 6 2008 4374
32. J.R. Tagat, S.W. McCombie, D. Nazareno, M.A. Labroli, Y. Xiao, R.W. Steensma, J.M. Strizki, B.M. Baroudy, K. Cox, J. Lachowicz, G. Varty, and R. Watkins J. Med. Chem. 47 2004 2405