Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4124-4129

  Ueda, Satoshi ^a   Kato, Manabu ^a   Inuki, Shinsuke ^a   Ohno, Hiroaki ^a   Evans, Barry ^b   Wang, Zi xuan ^b   Peiper, Stephen C ^b   Izumi, Kazuki ^a   Kodama, Eiichi ^a   Matsuoka, Masao ^a   Nagasawa, Hideko ^c   Oishi, Shinya ^a   Fujii, Nobutaka ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Anti HIV; Chemokine; CXCR4; Indole; SDF 1

Indexed keywords

5 ACETAMIDO 1 METHYLINDOLE 2 CARBOXAMIDE; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CYCLOPEPTIDE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; INDOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG DISPOSITION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PEPTIDE ANALYSIS; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

CHEMISTRY, PHARMACEUTICAL; CHEMOKINES; CHEMOTAXIS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PEPTIDES; PEPTIDES, CYCLIC; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 47149090722     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.092     Document Type: Article

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