Pyridine N-oxide derivatives: Unusual anti-HIV compounds with multiple mechanisms of antiviral action

Journal of Antimicrobial Chemotherapy

Volumn 55, Issue 2, 2005, Pages 135-138

  Balzarini, Jan ^a   Stevens, Miguel ^a   De Clercq, Erik ^a   Schols, Dominique ^a   Pannecouque, Christophe ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

HIV chemotherapy; NF B; NNRTI; Reverse transcriptase; Transcription inhibitors

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; JPL 10; JPL 133; JPL 153; JPL 32; JPL 71; JPL 74; JPL 78; JPL 88; PLACEBO; PYRIDINE 1 OXIDE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROTECTION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; MOUSE STRAIN; NONHUMAN; T LYMPHOCYTE; VIRUS GENE; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS RESISTANCE;

ANIMALS; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; HIV-1; HIV-2; HUMANS; PYRIDINES;

EID: 14744285125     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh530     Document Type: Article

References (4)

1. Balzarini, J., Stevens, M., Andrei, G. et al. (2002). Pyridine oxide derivatives: structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture. Helvetica Chimica Acta 85, 2961-74.
2. Stevens, M., Pannecouque, C., De Clercq, E. et al. (2003). Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives. Antimicrobial Agents and Chemotherapy 47, 2951-7.
3. Stevens, M., Pannecouque, C., De Clercq, E. et al. (2003). Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action. Antimicrobial Agents and Chemotherapy 47, 3109-16.
4. Stevens, M., Pannecouque, C., De Clercq, E. et al. (2003). Pyridine oxides represent a novel class of HIV transactivation inhibitors. The Tenth West Coast Retrovirus Meeting, Palm Springs, CA, 9-11 October 2003. Abstracts p. 44.