Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4704-4710

  Suchaud, Virginie ^a,b   Gavara, Laurent ^a,b   Giraud, Francis ^a,b   Nauton, Lionel ^a,b   Théry, Vincent ^a,b   Anizon, Fabrice ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b ICCF   (France)

Author keywords

In vitro antiproliferative activities; Kinase inhibitors; Pim kinases; Pyrazolo 4,3 a phenanthridines

Indexed keywords

10 CHLORO 3H PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 10 CHLORO 5 NITRO 3H PYRAZOLO[4,3 A]PHENANTHRIDINE; 3 (TETRAHYDRO 2H PYRAN 2 YL) 3H PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 3H PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 3H PYRAZOLO[4,3 A]PHENANTHRIDINE; 3H [1,3]DIOXOLO[4,5 J]PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 5 BROMO 6 NITROINDAZOLE; 5 NITRO 3H PYRAZOLO[4,3 A]PHENANTHRIDINE; 5 NITRO 3H [1,3]DIOXOLO[4,5 J]PYRAZOLO[4,3 A]PHENANTHRIDINE; 8 FLUORO 3H PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 8 FLUORO 5 NITRO 3H PYRAZOLO[4,3 A]PHENANTHRIDINE; 9 METHOXY 3H PYRAZOLO[4,3 A]PHENANTHRIDIN 5 AMINE; 9 METHOXY 5 NITRO 3H PYRAZOLO[4,3 A]PHENANTHRIDINE; ADENOSINE TRIPHOSPHATE; INDAZOLE DERIVATIVE; PHENANTHRIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; PYRAZOLO[4,3 A]PHENANTHRIDINE; UNCLASSIFIED DRUG; PROTO-ONCOGENE PROTEINS PIM; PYRAZOLE DERIVATIVE;

ARTICLE; BINDING SITE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR MODEL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENANTHRIDINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906934473     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.07.011     Document Type: Article

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