Synthesis and biological activities of 4-substituted pyrrolo[2,3-a] carbazole Pim kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 225-236

  Giraud, Francis ^a,b   Akué Gédu, Rufine ^a,b   Nauton, Lionel ^a,b   Candelon, Nicolas ^a,b   Debiton, Eric ^a,c   Théry, Vincent ^a,b   Anizon, Fabrice ^a,b   Moreau, Pascale ^a,b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b ICCF   (France)

^c INSERM   (France)

Author keywords

In vitro antiproliferative activities; Photo induced cyclization; Pim kinase inhibition; Pyrrolo 2,3 a carbazole; Suzuki coupling

Indexed keywords

1 (TERT BUTOXYCARBONYL) 1H INDOLE 3 CARBALDEHYDE; 3 (1H INDOL 3 YL) 2 (1H PYRROL 3 YL)PROP 2 ENOIC ACID; 4 NITRO 1 (PHENYLSULFONYL) 1H INDOLE 3 CARBALDEHYDE; 6 AMINO 1,10 DIHYDROPYRROLO[2,3 A]CARBAZOLE 4 CARBOXYLIC ACID; CARBAZOLE DERIVATIVE; METHYL 1,10 DIHYDROPYRROLO[2,3 A]CARBAZOLE 4 CARBOXYLIC ACID; METHYL 2 (1H PYRROL 3 YL) 3 [4 (TERT BUTOXYCARBONYL)AMINO] 1H INDOL 3 YL]PROPANOATE; METHYL 2 BROMO 3 [4 AMINO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL]PROP 2 ENOATE; METHYL 2 BROMO 3 [4 AZIDO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL]PROP 2 ENOATE; METHYL 2 BROMO 3 [4 NITRO 1 (PHENYLSULFONYL) 1H INDOL 3 YL]PROP 2 ENOATE; METHYL 2 BROMO 3 [4 NITRO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL]PROP 2 ENOATE; METHYL 3 (1H INDOL 3 YL) 2 (1H PYRROL 3 YL)PROP 2 ENOATE; METHYL 3 [1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 2 (1H PYRROL 3 YL)PROP 2 ENOATE; METHYL 3 [1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 2 [1 (TRIISOPROPYLSILYL) 1H PYRROL 3 YL]PROP 2 ENOATE; METHYL 3 [4 [BIS(TERT BUTOXYCARBONYL)AMINO] 1 (PHENYLSULFONYL) 1H INDOL 3 YL] 2 (1H PYRROL 3 YL)PROP 2 ENOATE; METHYL 3 [4 [BIS(TERT BUTOXYCARBONYL)AMINO] 1 (PHENYLSULFONYL) 1H INDOL 3 YL] 2 [1 (TRIISOPROPYLSILYL) 1H PYRROL 3 YL]PROP 2 ENOATE; METHYL 3 [4 [BIS(TERT BUTOXYCARBONYL)AMINO] 1 (PHENYLSULFONYL) 1H INDOL 3 YL] 2 BROMOPROP 2 ENOATE; METHYL 3 [4 AMINO 1 (PHENYLSULFONYL) 1H INDOL 3 YL] 2 BROMOPROP 2 ENOATE; METHYL 3 [4 AMINO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 2 (1H PYRROL 3 YL)PROP 2 ENOATE; METHYL 3 [4 AMINO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 2 [1 (TRIISOPROPYLSILYL) 1H PYRROL 3 YL]PROP 2 ENOATE; METHYL 3 [4 AZIDO 1 (TERT BUTOXYCARBONYL) 1H INDOL 3 YL] 2 [1 (TRIISOPROPYLSILYL) 1H PYRROL 3 YL]PROP 2 ENOATE; METHYL 6 (2 AMINOPHENYL) 1H INDOLE 4 CARBOXYLIC ACID; METHYL 6 (2,6 DIAMINOPHENYL) 1H INDOLE 4 CARBOXYLIC ACID; METHYL 6 [BIS(TERT BUTOXYCARBONYL)AMINO] 1,10 DIHYDROPYRROLO[2,3 A]CARBAZOLE 4 CARBOXYLIC ACID; METHYL 6 AMINO 1,10 DIHYDROPYRROLO[2,3 A]CARBAZOLE 4 CARBOXYLIC ACID; PROTEIN KINASE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 3; PYRROLO[2,3 A]CARBAZOLE 3 CARBALDEHYDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SEQUENCE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CYCLIZATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; SUZUKI REACTION;

ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84866086589     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.029     Document Type: Article

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