The Oct4 protein: More than a magic stemness marker

American Journal of Stem Cells

Volumn 3, Issue 2, 2014, Pages 74-82

  Zeineddine, Dana ^a   Hammoud, Aya Abou ^a,b   Mortada, Mohamad ^a   Boeuf, Hélène ^b  

^a LEBANESE UNIVERSITY   (Lebanon)

^b CNRS Bordeaux Segalen University   (France)

Author keywords

Cancer stem cells; Cell lineages; Embryonic stem cells; Oct4 Pou5f1; Pluripotency

Indexed keywords

JANUS KINASE; KRUPPEL LIKE FACTOR 4; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P53; RETINOIC ACID; STAT3 PROTEIN; SUMO 1 PROTEIN; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX2; UBIQUITIN PROTEIN LIGASE E3;

CARCINOGENICITY; CELL DIFFERENTIATION; DOWN REGULATION; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; NONHUMAN; ONCOGENE; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

EID: 84906925264     PISSN: None     EISSN: 21604150     Source Type: Journal    
DOI: None     Document Type: Review

References (81)

1. Scholer HR, Balling R, Hatzopoulos AK, Suzuki N, Gruss P. Octamer binding proteins confer transcriptional activity in early mouse embryo-genesis. EMBO J 1989; 8: 2551-7.
2. Yeom YI, Ha HS, Balling R, Scholer HR, Artzt K. Structure, expression and chromosomal location of the Oct-4 gene. Mech Dev 1991; 35: 171-179.
3. Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005; 6: 872-84.
4. [4] Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers ISchöler H, Smith A., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998; 95: 379 91.
5. Scholer HR. Octamania: the POU factors in murine development. Trends Genet 1991; 7: 323-329.
6. Palmieri SL, Peter W, Hess HSchöler HR, Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 1994; 166: 259-267.
7. Pesce M, Scholer HR. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 2001; 19: 271-8.
8. Jerabek S, Merino F Scholer HR.Cojocaru V., OCT4: Dynamic DNA binding pioneers stem cell pluripotency. Biochim Biophys Acta 2014; 1839: 138-154.
9. Pan GJ, Chang ZY, Scholer HR, Pei D. Stem cell pluripotency and transcription factor Oct4. Cell Res 2002; 12: 321-9.
10. Kehler J, Tolkunova E, Koschorz B, Pesce M, Gentile L, Boiani M Lomelí H, Nagy A, McLaughlin KJ, Schöler HR, Tomilin A., Oct4 is required for primordial germ cell survival. EMBO Rep 2004; 5: 1078-83.
11. Cauffman G Van de Velde H, Liebaers I, Van Steirteghem A., Oct-4 mRNA and protein expression during human preimplantation development. Mol Hum Reprod 2005; 11: 173-81.
12. Trouillas M, Saucourt C, Guillotin B, Gauthere-au X, Taupin JL, Moreau JF, Boeuf H. The LIF cytokine: towards adulthood. Eur Cytokine Netw 2009; 20: 51-62.
13. Trouillas M, Saucourt C, Guillotin B, Gauthere-au X, Ding L, Buchholz F, Doss MX, Sachinidis A, Hescheler J, Hummel O, Huebner N, Kolde R, Vilo J, Schulz H, Boeuf H. Three LIF-dependent signatures and gene clusters with atypi-cal expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives. BMC Genomics 2009; 10: 73.
14. Takeda J, Seino S, Bell GI. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res 1992; 20: 4613-20.
15. [15] Cauffman G, Liebaers I, Van Steirteghem A, Van de Velde H. POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos. Stem Cells 2006; 24: 2685-2691.
16. Verlinsky Y, Morozov G, Verlinsky O, Koukha-renko V, Rechitsky S, Goltsman E, Ivakhnenko V, Gindilis V, Strom CM, Kuliev A. Isolation of cDNA libraries from individual human preimplantation embryos. Mol Hum Reprod 1998; 4: 571-575.
17. Abdel-Rahman B, Fiddler M, Rappolee D, Per-gament E. Expression of transcription regulating genes in human preimplantation embryos. Hum Reprod 1995; 10: 2787-2792.
18. Hansis C, Grifo JA, Krey LC. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. Mol Hum Reprod 2000; 6: 999-1004.
19. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000; 18: 399-404.
20. Pera MF, Herszfeld D. Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2. Reprod Fertil Dev 1998; 10: 551-555.
21. Goto T, Adjaye J, Rodeck CH, Monk M. Identification of genes expressed in human primordial germ cells at the time of entry of the female germ line into meiosis. Mol Hum Reprod 1999; 5: 851-860.
22. Chambers I, Tomlinson SR. The transcriptional foundation of pluripotency. Development 2009; 136: 2311-2322.
23. Niwa H, Miyazaki J, Smith AG. Quantitative ex-pression of Oct-3/4 defines differentiation, de-differentiation or self-renewal of ES cells. Nat Genet 2000; 24: 372-376.
24. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 2005; 123: 917-929.
25. Le Bin GC, Muñoz-Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, Etienne-Dumeau C, Grabole N, Mulas C, Niwa H, Hadjantonakis AK, Nichols J. Oct4 is required for lineage prim-ing in the developing inner cell mass of the mouse blastocyst. Development 2014; 141: 1001-1010.
26. Hay DC, Sutherland L, Clark J, Burdon T. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. Stem Cells 2004; 22: 225-35.
27. Zafarana G, Avery SR, Avery K, Moore HD, Andrews PW. Specific knockdown of OCT4 in human embryonic stem cells by inducible short hairpin RNA interference. Stem Cells 2009; 27: 776-782.
28. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122: 947-956.
29. Niwa H. How is pluripotency determined and maintained? Development 2007; 134: 635-646.
30. Christophersen NS, Helin K. Epigenetic control of embryonic stem cell fate. J Exp Med 2010; 207: 2287-2295.
31. Dahéron L, Opitz SL, Zaehres H, Lensch MW, Andrews PW, Itskovitz-Eldor J, Daley GQ. LIF/ STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells 2004; 22: 770-8.
32. Pera MF, Trounson AO. Human embryonic stem cells: prospects for development. Development 2004; 131: 5515-5525.
33. Pera MF. Defining pluripotency. Nat Methods 2010; 7: 885-887.
34. Gafni O, Weinberger L, Mansour AA, Manor YS, Chomsky E, Ben-Yosef D, Kalma Y, Viukov S, Maza I, Zviran A, Rais Y, Shipony Z, Mukamel Z, Krupalnik V, Zerbib M, Geula S, Caspi I, Schneir D, Shwartz T, Gilad S, Amann-Zalcenstein D, Benjamin S, Amit I, Tanay A, Massarwa R, Novershtern N, Hanna JH. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013; 504: 282-286.
35. Hanna J, Cheng AW, Saha K, Kim J, Lengner CJ, Soldner F, Cassady JP, Muffat J, Carey BW, Jaenisch R. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A 2010; 107: 9222-9227.
36. Boeuf H, Hauss C, Graeve FD, Baran N, Kedinger C. Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells. J Cell Biol 1997; 138: 1207-1217.
37. Bourillot PY, Savatier P. Krüppel-like transcription factors and control of pluripotency. BMC Biol 2010; 8: 125.
38. Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, Hubner N, Savatier P. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Stem Cells 2009; 27: 1760-1771.
39. Mathieu ME, Saucourt C, Mournetas V, Gauthereau XThézé N, Praloran V, Thiébaud P, Bœuf H., LIF-Dependent Signaling: New Pieces in the Lego. Stem Cell Rev 2012; 8: 1-15.
40. Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, Matsuda T, Koide H, Yokota T. STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. J Biol Chem 2008; 283: 9713-9723.
41. Ura H, Murakami K, Akagi T, Kinoshita K, Yamaguchi S, Masui S, Niwa H, Koide H, Yokota T. Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation. EMBO J 2011; 30: 2190-2204.
42. Li Y, McClintick J, Zhong L, Edenberg HJ, Yoder MC, Chan RJ. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 2005; 105: 635-637.
43. Niwa H, Ogawa K, Shimosato D, Adachi K. A parallel circuit of LIF signalling pathways main-tains pluripotency of mouse ES cells. Nature 2009; 460: 118-122.
44. Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M. Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A 2009; 106: 12759-12764.
45. Mathieu ME, Faucheux C, Saucourt C, Soulet F, Gauthereau XFédou S, Trouillas M, Thézé N, Thiébaud P, Boeuf H., MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embry-onic cell fate. Development 2013; 140: 3311-3322.
46. Zeineddine D, Papadimou E, Chebli K, Gineste M, Liu J, Grey C, Thurig S, Behfar A, Wallace VA, Skerjanc ISPucéat M., Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development. Dev Cell 2006; 11: 535-546.
47. Stefanovic S, Puceat M. Oct-3/4: not just a gatekeeper of pluripotency for embryonic stem cell, a cell fate instructor through a gene dosage effect. Cell Cycle 2007; 6: 8-10.
48. Kopp JL, Ormsbee BD, Desler M, Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 2008; 26: 903-11.
49. Shimozaki K, Nakashima K, Niwa H, Taga T. Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development 2003; 130: 2505-12.
50. Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J 2013; 32: 938-953.
51. Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 2009; 186: 665-673.
52. Brumbaugh J, Hou Z, Russell JD, Howden SE, Yu P, Ledvina AR, Coon JJ, Thomson JA. Phosphorylation regulates human OCT4. Proc Natl Acad Sci U S A 2012; 109: 7162-7168.
53. Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J. Post-translational regulation of Oct4 transcriptional activity. PLoS One 2009; 4: e4467.
54. Swaney DL, Wenger CD, Thomson JA, Coon JJ. Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A 2009; 106: 995-1000.
55. Cai N, Li M, Qu J, Liu G-H, Izpisua Belmonte JC. Post-translational modulation of pluripotency. J Mol Cell Biol 2012; 4: 262-265.
56. Liao B, Jin Y. Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dos-age-dependent manner. Cell Res 2010; 20: 332-344.
57. Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y. Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. J Cell Physiol 2013; 228: 1443-1451.
58. Xu H, Wang W, Li C, Yu H, Yang A, Wang B, Jin Y. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res 2009; 19: 561-573.
59. Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, Sheng HZ, Zhao YX, Zhao YM, Jin Y. Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 2004; 279: 23495-23503.
60. Spelat R, Ferro F, Curcio F. Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation. J Biol Chem 2012; 287: 38279-38288.
61. Gill G. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev 2004; 18: 2046-2059.
62. Wei F Schlöer HR, Atchison ML, Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem 2007; 282: 21551-21560.
63. Wu Y, Guo Z, Wu H, Wang X, Yang L, Shi X, Du J, Tang B, Li W, Yang L, Zhang Y. SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. PLoS One 2012; 7: e39606.
64. [64] Koo BS, Lee SH, Kim JM, Huang S, Kim SH, Rho YS, Bae WJ, Kang HJ, Kim YS, Moon JH, Lim YC. Oct4 is a critical regulator of stemness in head and neck squamous carcinoma cells. Oncogene 2014; [Epub ahead of print].
65. Boumahdi S, Driessens G, Lapouge G, Rorive S, Nassar D, Le Mercier M, Delatte B, Caauwe A, Lenglez S, Nkusi EBrohée S, Salmon I, Dubois C, del Marmol V, Fuks F, Beck B, Blanpain C., SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 2014; 511: 246-50.
66. Abubaker K, Luwor RB, Zhu H, McNally O, Quinn MA, Burns CJ, Thompson EW, Findlay JK, Ahmed N. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden. BMC Cancer 2014; 14: 317.
67. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40: 499-507.
68. Hu T, Liu S, Breiter DR, Wang F, Tang Y, Sun S. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res 2008; 68: 6533-40.
69. Darini CY, Pisani DF, Hofman P, Pedeutour F, Sudaka I, Chomienne C, Dani C, Ladoux A. Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potential. Oncogene 2012; 31: 2438-49.
70. Patru C, Romao L, Varlet P, Coulombel L, Ra-poni E, Cadusseau J, Renault-Mihara F, Thirant C, Leonard N, Berhneim A, Mihalescu-Maingot M, Haiech JBièche I, Moura-Neto V, Daumas-Duport C, Junier MP, Chneiweiss H., CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors. BMC Cancer 2010; 10: 66.
71. Thirant C, Bessette B, Varlet P, Puget S, Cadusseau J, Tavares Sdos R, Studler JM, Silvestre DC, Susini A, Villa C, Miquel C, Bogeas A, Sure-na AL, Dias-Morais ALéonard N, Pflumio F, Bièche I, Boussin FD, Sainte-Rose C, Grill J, Daumas-Duport C, Chneiweiss H, Junier MP., Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors. PLoS One 2011; 6: e16375.
72. Thirant C, Galan-Moya EM, Dubois LG, Pinte S, Chafey P, Broussard C, Varlet P, Devaux B, Soncin F, Gavard J, Junier MP, Chneiweiss H. Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor. Stem Cells 2012; 30: 845-853.
73. Thirant C, Gavard J, Junier MP, Chneiweiss H. Critical multiple angiogenic factors secreted by glioblastoma stem-like cells underline the need for combinatorial anti-angiogenic therapeutic strategies. Proteomics Clin Appl 2013; 7: 79-90.
74. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-76.
75. Carey BW, Markoulaki S, Hanna JH, Faddah DA, Buganim Y, Kim J, Ganz K, Steine EJ, Cassady JP, Creyghton MP, Welstead GG, Gao Q, Jaenisch R. Reprogramming factor stoichiom-etry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 2011; 9: 588-98.
76. Buganim Y, Faddah DA, Jaenisch R. Mechanisms and models of somatic cell reprogramming. Nat Rev Genet 2013; 14: 427-39.
77. Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat Methods 2011; 8: 409-12.
78. Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008; 3: 568-74.
79. Inoue H, Nagata N, Kurokawa H Yamanaka S., iPS cells: a game changer for future medicine. EMBO J 2014; 33: 409-17.
80. Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell 2014; 156: 663-77.
81. Corpet F. Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res 1988; 16: 10881-90.