Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potential

Oncogene

Volumn 31, Issue 19, 2012, Pages 2438-2449

  Darini, C Y ^a,b,f   Pisani, D F ^a,b   Hofman, P ^c   Pedeutour, F ^a,b,d   Sudaka, I ^e   Chomienne, C ^c   Dani, C ^a,b   Ladoux, A ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c INSERM   (France)

^d UNIVERSITY HOSPITAL OF NICE   (France)

^e University of Côte d'Azur   (France)

^f CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

gene tracking; metastasis; Oct 4; tumour initiating cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GREEN FLUORESCENT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PUROMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE EXPRESSION; METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; TUMOR DIFFERENTIATION; TUMOR GENE; TUMOR GROWTH; TUMOR INITIATING CELL;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; MICE; MICE, SCID; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; PUROMYCIN; RECEPTORS, CXCR4; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861340293     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.421     Document Type: Article

References (53)

1. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. (2003). Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988. (Pubitemid 36418143)
2. Beier D, Hau P, Proescholdt M, Lohmeier A, Wischhusen J, Oefner PJ et al. (2007). CD133(+) and CD133(+) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67: 4010-4015. (Pubitemid 46815044)
3. Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A et al. (2008). An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40: 499-507. (Pubitemid 351601215)
4. Bonnet D, Dick JE. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737. (Pubitemid 27298715)
5. Carlisle AJ, Lyttle CA, Carlisle RY, Maris JM. (2009). CXCR4 expression heterogeneity in neuroblastoma cells due to ligandindependent regulation. Mol Cancer 8: 126.
6. Chambers I, Silva J, Colby D, Nichols J, Nijmeijer B, Robertson M et al. (2007). Nanog safeguards pluripotency and mediates germline development. Nature 450: 1230-1234.
7. Charafe-Jauffret E, Ginestier C, Iovino F, Wicinski J, Cervera N, Finetti P et al. (2009). Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 69: 1302-1313.
8. Charrad RS, Li Y, Delpech B, Balitrand N, Clay D, Jasmin C et al. (1999). Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nat Med 5: 669-676. (Pubitemid 29289431)
9. Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ et al. (2010). Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res 70: 10433-10444.
10. Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruizi Altaba A. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 17: 165-172. (Pubitemid 46107823)
11. Diehn M, Cho RW, Clarke MF. (2009). Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol 19: 78-86.
12. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS et al. (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
13. Felsher DW. (2004). Reversibility of oncogene-induced cancer. Curr Opin Genet Dev 14: 37-42. (Pubitemid 38167475)
14. Gassmann P, Haier J, Schluter K, Domikowsky B, Wendel C, Wiesner U et al. (2009). CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. Neoplasia 11: 651-661.
15. Gidekel S, Pizov G, Bergman Y, Pikarsky E. (2003). Oct-3/4 is a dosedependent oncogenic fate determinant. Cancer Cell 4: 361-370. (Pubitemid 37491097)
16. Harris MA, Yang H, Low BE, Mukherje J, Guha A, Bronson RT et al. (2008). Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 68: 10051-10059.
17. Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M et al. (2007). Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic. Cell Stem cell 1: 313-323. (Pubitemid 47355323)
18. Hochedlinger K, Plath K. (2009). Epigenetic reprogramming and induced pluripotency. Development 136: 509-523.
19. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. (2005). Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121: 465-477. (Pubitemid 40692305)
20. Huang CY, Lee CY, Chen MY, Yang WH, Chen YH, Chang CH et al. (2009). Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. J Cell Physiol 221: 204-212.
21. Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D et al. (2005). Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev 19: 214-223. (Pubitemid 40111117)
22. Kaufman DS. (2006). Challenges in the treatment of bladder cancer. Ann Oncol 17(Suppl 5): v106-v112. (Pubitemid 43985218)
23. Kucia M, Ratajczak J, Ratajczak MZ. (2005). Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells. Biol Cell 97: 133-146. (Pubitemid 40298268)
24. Lee J, Kim JY, Kang IY, Kim HK, Han YM, Kim J. (2007). The EWS-Oct-4 fusion gene encodes a transforming gene. Biochem J 406: 519-526. (Pubitemid 47425458)
25. Lengner CJ, Camargo FD, Hochedlinger K, Welstead GG, Zaidi S, Gokhale S et al. (2007). Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1: 403-415. (Pubitemid 47506536)
26. Levings PP, McGarry SV, Currie TP, Nickerson DM, McClellan S, Ghivizzani SC et al. (2009). Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res 69: 5648-5655.
27. le Viseur C, Hotfilder M, Bomken S, Wilson K, Rottgers S, Schrauder A et al. (2008). In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 14: 47-58. (Pubitemid 351885495)
28. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V et al. (2007). Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037.
29. Marangoni E, Lecomte N, Durand L, de Pinieux G, Decaudin D, Chomienne C et al. (2009). CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts. Br J Cancer 100: 918-922.
30. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K et al. (2007). Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 9: 625-635. (Pubitemid 47214724)
31. Monteiro J, Fodde R. (2010). Cancer stemness and metastasis: therapeutic consequences and perspectives. Eur J Cancer 46: 1198-1203.
32. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME et al. (2001). Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56. (Pubitemid 32225831)
33. Nguyen DX, Bos PD, Massague J. (2009). Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284.
34. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I et al. (1998). Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-391. (Pubitemid 28507326)
35. Niwa H, Miyazaki J, Smith AG. (2000). Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-376. (Pubitemid 30187435)
36. O'Brien CA, Kreso A, Dick JE. (2009). Cancer stem cells in solid tumors: an overview. Semin Radiat Oncol 19: 71-77.
37. O'Brien CA, Pollett A, Gallinger S, Dick JE. (2007). A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110. (Pubitemid 46067310)
38. Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P et al. (2007). Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 104: 973-978. (Pubitemid 46154721)
39. Rajagopalan V, El Kamar FG, Thayaparan R, Grossbard ML. (2005). Bone marrow metastases from glioblastoma multiforme-a case report and review of the literature. J Neurooncol 72: 157-161. (Pubitemid 40796466)
40. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C et al. (2007). Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115. (Pubitemid 46067311)
41. Rodriguez AM, Pisani D, Dechesne CA, Turc-Carel C, Kurzenne JY, Wdziekonski B et al. (2005). Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse. J ExpMed 201: 1397-1405. (Pubitemid 40664084)
42. Ruiz i Altaba A, Brand AH. (2009). Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer. EMBO Rep 10: 832-836.
43. Santagata S, Ligon KL, Hornick JL. (2007). Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol 31: 836-845. (Pubitemid 47165136)
44. Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S et al. (2004). MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature 431: 1112-1117. (Pubitemid 39472236)
45. Shackleton M, Quintana E, Fearon ER, Morrison SJ. (2009). Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 138: 822-829.
46. Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J et al. (2007). Molecular definition of breast tumor heterogeneity. Cancer Cell 11: 259-273. (Pubitemid 46349843)
47. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T et al. (2004). Identification of human brain tumour initiating cells. Nature 432: 396-401. (Pubitemid 39551674)
48. Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM et al. (2009). Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4: 129-140.
49. Wang J, Wang H, Li Z, Wu Q, Lathia JD, McLendon RE et al. (2008). c-Myc is required for maintenance of glioma cancer stem cells. PLoS One 3: e3769.
50. Ying QL, Nichols J, Evans EP, Smith AG. (2002). Changing potency by spontaneous fusion. Nature 416: 545-548. (Pubitemid 34288857)
51. Zeelenberg IS, Ruuls-Van Stalle L, Roos E. (2001). Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma. J Clin Invest 108: 269-277. (Pubitemid 32656251)
52. Zeineddine D, Papadimou E, Chebli K, Gineste M, Liu J, Grey C et al. (2006). Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development. Dev Cell 11: 535-546. (Pubitemid 44430895)
53. Zhang Y, Ma B, Fan Q. (2009). Mechanisms of breast cancer bone metastasis. Cancer Lett 292: 1-7.