Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming

Cell Research

Volumn 24, Issue 9, 2014, Pages 1121-1136

  Chen, Guofang ^a   Xu, Xinxiu ^a,b   Zhang, Lihong ^a   Fu, Yanbin ^b   Wang, Min ^a   Gu, Haifeng ^a   Xie, Xin ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

autocrine; embryonic stem cell; iPSC; self renewal; sunitinib; Sutent; VEGF

Indexed keywords

ANTINEOPLASTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDOLE DERIVATIVE; LEUKEMIA INHIBITORY FACTOR; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SUNITINIB; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOCRINE EFFECT; BIOLOGICAL MODEL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; EMBRYONIC STEM CELL; ENDODERM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE SILENCING; HUMAN; METABOLISM; MOUSE; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CELLULAR REPROGRAMMING; EMBRYONIC STEM CELLS; ENDODERM; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDOLES; LEUKEMIA INHIBITORY FACTOR; MICE; MODELS, BIOLOGICAL; PLURIPOTENT STEM CELLS; PROTEIN KINASE INHIBITORS; PYRROLES; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84906904987     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.112     Document Type: Article

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