Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data

Drug Metabolism and Disposition

Volumn 42, Issue 9, 2014, Pages 1447-1455

  Craig, Evelyn L ^a   Zhao, Bin ^a   Cui, Jason Z ^b   Novalen, Maria ^a   Miksys, Sharon ^a   Tyndale, Rachel F ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDE; COTININE; HYDROXYCOTININE; NICOTINE; NICOTINE 1-N-OXIDE; NORCOTININE; NORNICOTINE;

ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL MODEL; AREA UNDER THE CURVE; BRAIN; MALE; METABOLISM; PLASMA; RAT; WISTAR RAT;

ANIMALS; AREA UNDER CURVE; BRAIN; COTININE; CYCLIC N-OXIDES; MALE; MODELS, ANIMAL; NICOTINE; PLASMA; RATS; RATS, WISTAR;

EID: 84906860943     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.058719     Document Type: Article

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