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Volumn 30, Issue 1-2, 2005, Pages 3-17

Developmental pharmacology and toxicology: Biotransformation of drugs and other xenobiotics during postnatal development

Author keywords

Anxiolytic agent; Human hepatic S9; In vitro metabolism; Metabolite identification; RWJ 51521

Indexed keywords

1 NAPHTHOL; 2 AMINOPHENOL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; ALCOHOL; BILIRUBIN; CYTOCHROME P450 ISOENZYME; GLUCOCORTICOID; GLUCURONOSYLTRANSFERASE; ISOENZYME; MORPHINE; PHENOBARBITAL; PHENOLPHTHALEIN; SEROTONIN; STEROID; TESTOSTERONE; XENOBIOTIC AGENT;

EID: 21344466542     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03226403     Document Type: Review
Times cited : (15)

References (91)
  • 1
    • 0014735042 scopus 로고
    • Die aktivität der N- und O-demethylase in der leber des menschen
    • Ackermann E, Heinrich I (1970) Die Aktivität der N- und O-Demethylase in der Leber des Menschen (The activity of the N- and O-demethylase in the liver of the human being). Biochem. Pharmacol. 19, 327-342
    • (1970) Biochem. Pharmacol. , vol.19 , pp. 327-342
    • Ackermann, E.1    Heinrich, I.2
  • 2
    • 0015103289 scopus 로고
    • The monooxygenase system in the human fetal liver: Subcellular distribution and studies on in vitro metabolism of aniline
    • Ackermann E, Rane A (1971) The monooxygenase system in the human fetal liver: subcellular distribution and studies on in vitro metabolism of aniline. Chem-Biol. Interactions 3, 233-234
    • (1971) Chem. Biol. Interactions , vol.3 , pp. 233-234
    • Ackermann, E.1    Rane, A.2
  • 6
    • 21344433592 scopus 로고
    • German translation by Klinger W. Publ. House Medicine, Leningrad, VEB Verlag Volk und Gesundheit Berlin
    • Astrachanzewa LZ (1972) Geratric Pharmacology (in Russian). German translation by Klinger W (1977). Publ. House Medicine, Leningrad, VEB Verlag Volk und Gesundheit Berlin
    • (1972) Geratric Pharmacology (In Russian)
    • Astrachanzewa, L.Z.1
  • 7
    • 0017734610 scopus 로고
    • Ontogenetic expression of polycyclic aromatic compounds inducible monooxygenases activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems
    • Atlas S A, Boobis A R, Feiton J S, Thorgeirsson S S, Neben DW (1977) Ontogenetic expression of polycyclic aromatic compounds inducible monooxygenases activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems. J. Biol. Chem. 252, 4712-4721
    • (1977) J. Biol. Chem. , vol.252 , pp. 4712-4721
    • Atlas, S.A.1    Boobis, A.R.2    Feiton, J.S.3    Thorgeirsson, S.S.4    Neben, D.W.5
  • 8
    • 21344459710 scopus 로고
    • Biochemical factors in the activation and inactivation of drugs
    • Axelrod J (1960) Biochemical factors in the activation and inactivation of drugs. Arch. exp. Path. Pharm. 238, 24-35
    • (1960) Arch. Exp. Path. Pharm. , vol.238 , pp. 24-35
    • Axelrod, J.1
  • 9
    • 0022477834 scopus 로고
    • Hepatic elimination kinetics od organic anions in rats: Developmental aspects and influence of phenobarbital
    • Barth A, Klinger W, Hoppe H (1986) Hepatic elimination kinetics od organic anions in rats:developmental aspects and influence of phenobarbital. Arch. Int. Pharmacodyn. Ther. 283:16-29
    • (1986) Arch. Int. Pharmacodyn. Ther. , vol.283 , pp. 16-29
    • Barth, A.1    Klinger, W.2    Hoppe, H.3
  • 10
    • 0015102733 scopus 로고
    • Effect of development on the activity of microsomal drug metabolizing enzymes in rat liver
    • Basu TK, Dickerson JWT, Parke DVW (1971) Effect of development on the activity of microsomal drug metabolizing enzymes in rat liver. Biochem. J. 124, 19-24
    • (1971) Biochem. J. , vol.124 , pp. 19-24
    • Basu, T.K.1    Dickerson, J.W.T.2    Parke, D.V.W.3
  • 11
    • 0018666951 scopus 로고
    • Senescent changes in rodent hepatic epoxide metabolism
    • Birnbaum LS, Baird MB (1979) Senescent changes in rodent hepatic epoxide metabolism. Chem. Biol, Interact. 26:254-256
    • (1979) Chem. Biol. Interact. , vol.26 , pp. 254-256
    • Birnbaum, L.S.1    Baird, M.B.2
  • 12
    • 21344449985 scopus 로고
    • The development of the hippuric acid-synthesizing system in the rat
    • Brandt IK (1964) The development of the hippuric acid-synthesizing system in the rat. Develop. Biol. 10, 202-215
    • (1964) Develop. Biol. , vol.10 , pp. 202-215
    • Brandt, I.K.1
  • 14
    • 0014558961 scopus 로고
    • Phenosulfotransferase in the developing rat
    • Carrol J (1969) Phenosulfotransferase in the developing rat. Am. J. Clin. Nutr. 22:978-985
    • (1969) Am. J. Clin. Nutr. , vol.22 , pp. 978-985
    • Carrol, J.1
  • 15
    • 21344458042 scopus 로고
    • Maturation of liver enzyme that conjugates sulfobromophtalein sodium (BSP) and glutathione
    • Combes B, Stakelum GS (1961) Maturation of liver enzyme that conjugates sulfobromophtalein sodium (BSP) and glutathione. J. Clin. Invest. 40:1030-1031
    • (1961) J. Clin. Invest. , vol.40 , pp. 1030-1031
    • Combes, B.1    Stakelum, G.S.2
  • 17
    • 0000888830 scopus 로고
    • Developmental pharmacology
    • Done AK (1964) Developmental pharmacology. Clin. Pharmacol. Ther. 5, 432-479
    • (1964) Clin. Pharmacol. Ther. , vol.5 , pp. 432-479
    • Done, A.K.1
  • 18
    • 0013862507 scopus 로고
    • Perinatal pharmacology
    • Done AK (1966) Perinatal pharmacology. Ann. Rev. Pharmacol. 6, 189-208
    • (1966) Ann. Rev. Pharmacol. , vol.6 , pp. 189-208
    • Done, A.K.1
  • 20
    • 0013926154 scopus 로고
    • Variations in the glucuronide formation by perinatal liver
    • Dutton GJ (1966) Variations in the glucuronide formation by perinatal liver. Biochem. Pharmacol. 15, 947-951
    • (1966) Biochem. Pharmacol. , vol.15 , pp. 947-951
    • Dutton, G.J.1
  • 21
    • 26744468881 scopus 로고
    • Multiplicity of liver uridine 5-pyrophosphate glucuronyltrans-ferase from ist varying pattern of development with different substrates and species
    • Dutton GJ, Lawes J (1966) Multiplicity of liver uridine 5-pyrophosphate glucuronyltrans-ferase from ist varying pattern of development with different substrates and species. Biochem. J. 98, 30p
    • (1966) Biochem. J. , vol.98
    • Dutton, G.J.1    Lawes, J.2
  • 22
    • 0018068219 scopus 로고
    • Evidence in rat and mouseliver for temporal control of two polycyclic aromatic inducible forms of cytochrome P-450
    • Guenthner TM, Nebert DW (1978) Evidence in rat and mouseliver for temporal control of two polycyclic aromatic inducible forms of cytochrome P-450. Eur. J. Biochem. 91:449-456
    • (1978) Eur. J. Biochem. , vol.91 , pp. 449-456
    • Guenthner, T.M.1    Nebert, D.W.2
  • 23
    • 0009541615 scopus 로고
    • Drug metabolism in the newborn rabbit
    • Fouts JR, Adamson RH (1959) Drug metabolism in the newborn rabbit. Science 129, 897-898
    • (1959) Science , vol.129 , pp. 897-898
    • Fouts, J.R.1    Adamson, R.H.2
  • 27
    • 0014201074 scopus 로고
    • The developmental multiplicity and isoenzyme status of rat esterases
    • Holmes RS, Masters CJ (1967) The developmental multiplicity and isoenzyme status of rat esterases. Biochim. Biophys. Acta 146: 138-150
    • (1967) Biochim. Biophys. Acta , vol.146 , pp. 138-150
    • Holmes, R.S.1    Masters, C.J.2
  • 29
    • 0024554449 scopus 로고
    • Influence of prenatal administration of cadmium on postnatal development and inducibility of hepatic monooxygenases in rats
    • Jahn F, Klinger W. (1989) Influence of prenatal administration of cadmium on postnatal development and inducibility of hepatic monooxygenases in rats. Phamacol. Toxicol. 64:292-292
    • (1989) Phamacol. Toxicol. , vol.64 , pp. 292-292
    • Jahn, F.1    Klinger, W.2
  • 30
    • 0001569170 scopus 로고
    • Inability of newborn mice and guinea pigs to metabolize drugs
    • Jondorf WR, Maickel RT, Brodie BB (1958) Inability of newborn mice and guinea pigs to metabolize drugs. Biochem. Pharmacol. 1, 352-354
    • (1958) Biochem. Pharmacol. , vol.1 , pp. 352-354
    • Jondorf, W.R.1    Maickel, R.T.2    Brodie, B.B.3
  • 32
    • 21344465336 scopus 로고
    • The glucuronide-synthesizing system in the mouse and ist relationship to β-glucuronidase
    • Karunairatnam MC, Kerr LM, Levvy GA (1949) The glucuronide-synthesizing system in the mouse and ist relationship to β-glucuronidase. Biochem. J. 45, 496
    • (1949) Biochem. J. , vol.45 , pp. 496
    • Karunairatnam, M.C.1    Kerr, L.M.2    Levvy, G.A.3
  • 33
    • 0009835687 scopus 로고
    • Variation in the activity of liver microsomal drug metabolizing enzymes in rats in relation to the age
    • Kato R, Vassanelli P, Frontino G, Chiesara E (1964) Variation in the activity of liver microsomal drug metabolizing enzymes in rats in relation to the age. Biochem. Pharmacol. 13, 1037-1051
    • (1964) Biochem. Pharmacol. , vol.13 , pp. 1037-1051
    • Kato, R.1    Vassanelli, P.2    Frontino, G.3    Chiesara, E.4
  • 35
    • 0018607523 scopus 로고
    • In vivo and in vitro inhibition of 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity in rat liver by actionomycin D and 7,8-benzoflavone
    • Kleeberg U, Grohmann G, Volkmann R, Steinen H, Klinger W (1979) In vivo and in vitro inhibition of 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity in rat liver by actionomycin D and 7,8-benzoflavone. Pol. J. Phamac. Pharm. 31:675-681
    • (1979) Pol. J. Phamac. Pharm. , vol.31 , pp. 675-681
    • Kleeberg, U.1    Grohmann, G.2    Volkmann, R.3    Steinen, H.4    Klinger, W.5
  • 36
    • 0022331023 scopus 로고
    • Increased response of cytochrome P450 dependent biotransformation reactions in rat liver to repeated administration of inducers
    • Kleeberg U, Sommer M, Klinger W (1985) Increased response of cytochrome P450 dependent biotransformation reactions in rat liver to repeated administration of inducers. Arch. Toxicol. Suppl. 8:361-365
    • (1985) Arch. Toxicol. Suppl. , vol.8 , pp. 361-365
    • Kleeberg, U.1    Sommer, M.2    Klinger, W.3
  • 38
    • 0013828797 scopus 로고
    • The concentration of L-ascorbic acid in the organs of rats of various age and sex upon treatment with barbital
    • 1965
    • Klinger W, Ankermann H (1965) The concentration of L-ascorbic acid in the organs of rats of various age and sex upon treatment with barbital. Actabiol. med. german., 14, 764-773 (1965)
    • (1965) Actabiol. Med. German , vol.14 , pp. 764-773
    • Klinger, W.1    Ankermann, H.2
  • 39
    • 21344471805 scopus 로고
    • Untersuchungen zum mechanismus der enzyminduktion bei ratten und mäusen. VI. Der einfluß des lebensalters auf die L- askorbinsäure-normausscheidung und ihre steigerung sowie auf die hexobarbitalschlafzeit und ihre verkürzung durch barbital
    • Klinger W, Kramer B (1965) Untersuchungen zum Mechanismus der Enzyminduktion bei Ratten und Mäusen. VI. Der Einfluß des Lebensalters auf die L-Askorbinsäure-Normausscheidung und ihre Steigerung sowie auf die Hexobarbitalschlafzeit und ihre Verkürzung durch Barbital. Acta biol. med. german. 15, 7707-711
    • (1965) Acta Biol. Med. German , vol.15 , pp. 7707-7711
    • Klinger, W.1    Kramer, B.2
  • 40
    • 0013997952 scopus 로고
    • Die Hexobarbitalnarkose bei infantilen ratten
    • Klinger W, Ankermann H (1966) Die Hexobarbitalnarkose bei infantilen Ratten. Acta biol. med. germ. 17:357-359
    • (1966) Acta Biol. Med. Germ. , vol.17 , pp. 357-359
    • Klinger, W.1    Ankermann, H.2
  • 41
    • 0014367377 scopus 로고
    • Untersuchungen zum mechanismus der enzyminduktion. XIV. Der einfluss des lebensalters auf die aktivität und induzierbarkeit der phenazon-hydrolase, aminophenazon-N-demethylase, kodein-O-demeth-ylase und nitro-reduktase der rattenleber
    • Klinger W, Kusch T, Neugebauer A, Splinter FK, Ankermann H (1968) Untersuchungen zum Mechanismus der Enzyminduktion. XIV. Der Einfluss des Lebensalters auf die Aktivität und Induzierbarkeit der Phenazon-Hydrolase, Aminophenazon-N-Demethylase, Kodein-O-Demeth-ylase und Nitro-Reduktase der Rattenleber. Acta biol. med. germ. 21:257-269
    • (1968) Acta Biol. Med. Germ. , vol.21 , pp. 257-269
    • Klinger, W.1    Kusch, T.2    Neugebauer, A.3    Splinter, F.K.4    Ankermann, H.5
  • 42
    • 0017091934 scopus 로고
    • Developmental aspects of xenobiotics transformation
    • Klinger W, Müller D. (1976) Developmental aspects of xenobiotics transformation. Environm. Health Perspect. 18:13-23
    • (1976) Environm. Health Perspect. , vol.18 , pp. 13-23
    • Klinger, W.1    Müller, D.2
  • 43
    • 0017607173 scopus 로고
    • Ethylmorphine N-demethylation by liver homogenate of newborn and adult rats; enzyme kinetics and age course of Vmax and Km
    • Klinger W, Müller D, (1977) Ethylmorphine N-demethylation by liver homogenate of newborn and adult rats; enzyme kinetics and age course of Vmax and Km. Acta biol. med. germ. 36:1149-1159
    • (1977) Acta Biol. Med. Germ. , vol.36 , pp. 1149-1159
    • Klinger, W.1    Müller, D.2
  • 44
    • 84912328972 scopus 로고
    • Induction and its depencence on development
    • Estabrook RW, Lindenlaub E (eds), Schattauer Stuttgart New York
    • Klinger W, Müller D, Kleeberg U (1979) Induction and its depencence on development, In: Estabrook RW, Lindenlaub E (eds) The Induction of Drug Metabolism. Symp. Med. Hoechst 14, Schattauer Stuttgart New York, pp. 517-544
    • (1979) The Induction of Drug Metabolism. Symp. Med. Hoechst 14 , pp. 517-544
    • Klinger, W.1    Müller, D.2    Kleeberg, U.3
  • 45
    • 0020319719 scopus 로고
    • Biotransformation of drugs and other xenobiotics during postnatal development
    • Klinger W (1982) Biotransformation of drugs and other xenobiotics during postnatal development. Pharmac. Ther. 16:377-429
    • (1982) Pharmac. Ther. , vol.16 , pp. 377-429
    • Klinger, W.1
  • 46
    • 0021052914 scopus 로고
    • Pharmacology of the developing digestive system
    • Klinger W (1983) Pharmacology of the developing digestive system. Pharmac. Ther. 22, 41-51
    • (1983) Pharmac. Ther. , vol.22 , pp. 41-51
    • Klinger, W.1
  • 47
    • 0021091536 scopus 로고
    • Influence of impairment of the immune system on hepatic biotransformation reaction, their postnatal development and inducibility
    • Klinger W, Müller D, Danz M, Kob D, Madry M (1983) Influence of impairment of the immune system on hepatic biotransformation reaction, their postnatal development and inducibility. Exp. Pathol. 24:219-225
    • (1983) Exp. Pathol. , vol.24 , pp. 219-225
    • Klinger, W.1    Müller, D.2    Danz, M.3    Kob, D.4    Madry, M.5
  • 48
    • 21344440185 scopus 로고
    • Epigenetic imprinting of drug metabolism
    • Magyar T, Scuts T, Vereczky L (eds). Sect 4. Pergamon Oxford/Akademiai Kiado Budapest 1985
    • Klinger W, Jahn F (1985) Epigenetic imprinting of drug metabolism. In: Magyar T, Scuts T, Vereczky L (eds) Proc 4th Congr Hung Pharmacol Soc Budapest 1985. vol 2 Sect 4. Pergamon Oxford/Akademiai Kiado Budapest 1985, pp 384-397
    • (1985) Proc. 4th Congr Hung Pharmacol Soc Budapest 1985 , vol.2 , pp. 384-397
    • Klinger, W.1    Jahn, F.2
  • 49
    • 0023185456 scopus 로고
    • Developmental aspects of enzyme induction and inhibition
    • Klinger W (1987) Developmental Aspects of Enzyme Induction and Inhibition. Pharmac. Ther. 33:55-61
    • (1987) Pharmac. Ther. , vol.33 , pp. 55-61
    • Klinger, W.1
  • 50
    • 0023126203 scopus 로고
    • Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level
    • Klinger W, Karge E (1987) Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level. Exp. Pathol. 31:117-124
    • (1987) Exp. Pathol. , vol.31 , pp. 117-124
    • Klinger, W.1    Karge, E.2
  • 52
    • 9844243743 scopus 로고
    • Biotransformation of xenobiotics during ontogenetic development
    • Ruckpaul K and Rein H (eds): Akademie-Verlag Berlin
    • Klinger W (1990) Biotransformation of Xenobiotics During Ontogenetic Development, In: Ruckpaul K and Rein H (eds): Frontiers in Biotransformation vol 2, Akademie-Verlag Berlin, pp 113-149
    • (1990) Frontiers in Biotransformation , vol.2 , pp. 113-149
    • Klinger, W.1
  • 53
    • 21344471345 scopus 로고
    • Developmental regulation of biotransformation of drugs and other xenobiotics
    • Arinc E, Schenkman JB, Hodgson E (eds): NATO ASI Series
    • Klinger W (1995) Developmental regulation of biotransformation of drugs and other xenobiotics. In: Arinc E, Schenkman JB, Hodgson E (eds): Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series Vol. H 90, 237-248
    • (1995) Molecular Aspects of Oxidative Drug Metabolizing Enzymes , vol.H90 , pp. 237-248
    • Klinger, W.1
  • 54
    • 0001926012 scopus 로고    scopus 로고
    • Biotransformation of drugs and other xenobiotics during postnatal development
    • Klinger W (1996) Biotransformation of drugs and other xenobiotics during postnatal development. Exp. Toxic. Path. 48, Suppl. I, 1-88
    • (1996) Exp. Toxic. Path. , vol.48 , Issue.SUPPL. I , pp. 1-88
    • Klinger, W.1
  • 55
    • 21344455013 scopus 로고
    • Die beeinflussung des ascorbinsäure-stoffwechsels durch verschiedene pharmaka bei ratten
    • 1963
    • Koch M, Klinger W (1963) Die Beeinflussung des Ascorbinsäure- Stoffwechsels durch verschiedene Pharmaka bei Ratten. Acta biol.med.germ. 1o, 561-571, 1963
    • (1963) Acta Biol.Med.Germ. , vol.10 , pp. 561-571
    • Koch, M.1    Klinger, W.2
  • 57
    • 0019274719 scopus 로고
    • Postnatal development of renal and hepatic drug-metabolizing enzymes in male and female Fischer 344 rats
    • Kuo CH, Hook JB (1980) Postnatal development of renal and hepatic drug-metabolizing enzymes in male and female Fischer 344 rats. Life Sci. 27:2433-2438
    • (1980) Life Sci. , vol.27 , pp. 2433-2438
    • Kuo, C.H.1    Hook, J.B.2
  • 58
    • 73849153255 scopus 로고
    • Die thalidomid-embryopathie (thalidomide embryopathy)
    • Lenz W, Knapp K (1962) Die Thalidomid-Embryopathie (Thalidomide Embryopathy). Dtsch. med. Wschr. 87. 1232
    • (1962) Dtsch. Med. Wschr. , vol.87 , pp. 1232
    • Lenz, W.1    Knapp, K.2
  • 59
    • 21344452468 scopus 로고
    • Two cytoplasmic proteins from rat liver and their role in hepatic uptake of sulfobromophthalein (BSP) and bilirubin
    • Levi AJ, Gatmaitan Z, Arias IM (1968) Two cytoplasmic proteins from rat liver and their role in hepatic uptake of sulfobromophthalein (BSP) and bilirubin. J. clin. Invest. 47, 61a
    • (1968) J. Clin. Invest. , vol.47
    • Levi, A.J.1    Gatmaitan, Z.2    Arias, I.M.3
  • 60
    • 0014684242 scopus 로고
    • Deficiency of hepatic organic anion-binding proptein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn
    • Levi AJ, Gatmaitan Z, Arias IM ibid. (1969) Deficiency of hepatic organic anion-binding proptein as a possible cause of non-haemolytic unconjugated hyperbilirubinaemia in the newborn. Lancet II, 139-140
    • (1969) Lancet , vol.2 , pp. 139-140
    • Levi, A.J.1    Gatmaitan, Z.2    Arias, I.M.3
  • 61
    • 0014955282 scopus 로고
    • Deficiency of hepatic organic anion-binding protein, impaired organic anion uptake by liver and "physiologic" jaundice in newborn monkeys
    • Levi AJ, Gatmaitan Z, Arias IM ibid. (1970) Deficiency of hepatic organic anion-binding protein, impaired organic anion uptake by liver and "physiologic" jaundice in newborn monkeys. New Engl. J. Med. 283, 1136-1139
    • (1970) New Engl. J. Med. , vol.283 , pp. 1136-1139
    • Levi, A.J.1    Gatmaitan, Z.2    Arias, I.M.3
  • 62
    • 0021842692 scopus 로고
    • Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalyzed mixed function oxidases in the rat: Induction by 3-methylcholanthrene
    • Lum PY, Walker S, Ioannides C (1985) Foetal and neonatal development of cytochrome P-450 and cytochrome P-448 catalyzed mixed function oxidases in the rat: Induction by 3-methylcholanthrene. Toxicol. 35:307-317
    • (1985) Toxicol. , vol.35 , pp. 307-317
    • Lum, P.Y.1    Walker, S.2    Ioannides, C.3
  • 64
    • 0014720619 scopus 로고
    • Developmental pharmacology
    • Mirkin BL (1970) Developmental pharmacology. Ann. rev. Pharmacol 10, 255-272
    • (1970) Ann. Rev. Pharmacol , vol.10 , pp. 255-272
    • Mirkin, B.L.1
  • 65
    • 0017279526 scopus 로고
    • Glutathione-S-epoxide transferase activity during development and the effect of partial hepatectomy
    • Mukhtar H, Bresnick E (1976) Glutathione-S-epoxide transferase activity during development and the effect of partial hepatectomy. Cancer Res. 36:937-940
    • (1976) Cancer Res. , vol.36 , pp. 937-940
    • Mukhtar, H.1    Bresnick, E.2
  • 66
    • 0015189409 scopus 로고
    • Die aktivität der nitroreduktase und deren induzierbarkeit durch barbital in der leber von ratten verschiedenen alters
    • Müller D, Reichenbach F, Klinger W (1971) Die Aktivität der Nitroreduktase und deren Induzierbarkeit durch Barbital in der Leber von Ratten verschiedenen Alters. Acta biol. med. germ. 27:605-609
    • (1971) Acta Biol. Med. Germ. , vol.27 , pp. 605-609
    • Müller, D.1    Reichenbach, F.2    Klinger, W.3
  • 67
    • 0020971522 scopus 로고
    • The influence of triiodothyronine (T3) on the postnatal development of drug metabolism in rat liver
    • Müller, D, Greiling K, Greiling H, Klinger W (1983) The influence of triiodothyronine (T3) on the postnatal development of drug metabolism in rat liver. Biomed. Biochim. Acta 42:981-987
    • (1983) Biomed. Biochim. Acta , vol.42 , pp. 981-987
    • Müller, D.1    Greiling, K.2    Greiling, H.3    Klinger, W.4
  • 68
    • 0344039728 scopus 로고
    • Genetic aspects of enzyme induction by drugs and chemical carcinogens
    • Estabrook RW, Lindenlaub E (eds), Symp. Med. Hoechst 14, Schattauer Stuttgart New York
    • Nebert DW (1979) Genetic aspects of enzyme induction by drugs and chemical carcinogens, in: The Induction of Drug Metabolism, Estabrook RW, Lindenlaub E (eds), Symp. Med. Hoechst 14, Schattauer Stuttgart New York, pp 419-452
    • (1979) The Induction of Drug Metabolism , pp. 419-452
    • Nebert, D.W.1
  • 70
    • 0028007371 scopus 로고
    • Cytochrome P450: Evolution and functional diversity
    • Nebert DW, Mckinnon RA (1994) Cytochrome P450: Evolution and functional diversity. Prog. Liver Dis. 12:63-97
    • (1994) Prog. Liver Dis. , vol.12 , pp. 63-97
    • Nebert, D.W.1    Mckinnon, R.A.2
  • 73
    • 0018886929 scopus 로고
    • Biotransformation of xenobiotics in the fetus
    • Pelkonen O (1980) Biotransformation of xenobiotics in the fetus. Pharmac. Ther. 10:261-281
    • (1980) Pharmac. Ther. , vol.10 , pp. 261-281
    • Pelkonen, O.1
  • 75
    • 0022197022 scopus 로고
    • Aging and drug disposition
    • Schmucker DL (1985) Aging and drug disposition. Pharmacol. Rev. 37:133-148
    • (1985) Pharmacol. Rev. , vol.37 , pp. 133-148
    • Schmucker, D.L.1
  • 76
    • 0014830947 scopus 로고
    • Perinatal development of drug metabolizing enzyme activity in swine
    • Short CR, Davies LE (1970) Perinatal development of drug metabolizing enzyme activity in swine. J. Pharmacol. exp. Ther. 174, 185-196
    • (1970) J. Pharmacol. Exp. Ther. , vol.174 , pp. 185-196
    • Short, C.R.1    Davies, L.E.2
  • 77
    • 0014877630 scopus 로고
    • A study of the mechanism responsible for the sensitivity of newborn rats to pregnanolone
    • Soyka LF, Gyermek L, Campbel P (1970) A study of the mechanism responsible for the sensitivity of newborn rats to pregnanolone. J. Pharmac. exp. Ther. 175:276-282
    • (1970) J. Pharmac. Exp. Ther. , vol.175 , pp. 276-282
    • Soyka, L.F.1    Gyermek, L.2    Campbel, P.3
  • 80
    • 80051823470 scopus 로고
    • Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol
    • Sutherland JM (1959) Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol. A.M.A.J.Dis. Child. 97:761-767
    • (1959) A.M.A.J.Dis. Child. , vol.97 , pp. 761-767
    • Sutherland, J.M.1
  • 81
    • 21344469375 scopus 로고
    • Developmental pharmacology
    • Szorady I (1982) Developmental Pharmacology. Trends Pharmacol. Sci. 3:142-144
    • (1982) Trends Pharmacol. Sci. , vol.3 , pp. 142-144
    • Szorady, I.1
  • 82
    • 21344440649 scopus 로고
    • Age dependent N-hydroxylation of aromatic amines andtoxicity
    • Uehleke H (1964) Age dependent N-hydroxylation of aromatic amines andtoxicity. Proc. Europ. Soc. Study Drug tox. 4:140-144
    • (1964) Proc. Europ. Soc. Study Drug Tox. , vol.4 , pp. 140-144
    • Uehleke, H.1
  • 83
    • 0002802354 scopus 로고
    • Mammalian aldehyde dehydrogenase genes: Classification based on evolution, structure and regulation
    • Vasiliou V, Weiner H, Marselos M, Neben DW (1995) Mammalian aldehyde dehydrogenase genes: Classification based on evolution, structure and regulation. Europ. J. Drug Metab. Pharmacokinetics Spec. Issue 53-64
    • (1995) Europ. J. Drug Metab. Pharmacokinetics , Issue.SPEC. ISSUE , pp. 53-64
    • Vasiliou, V.1    Weiner, H.2    Marselos, M.3    Neben, D.W.4
  • 84
    • 0020374653 scopus 로고
    • Ontogenesis, induction, inhibition, tissue distribution, immunological behaviour and purification of microsomal epoxide hydrolase with 16a, 17a-epoxyandrostene-3-one as substrate
    • Vogel-Bindel U, Bentley P, Oesch F (1982) Ontogenesis, induction, inhibition, tissue distribution, immunological behaviour and purification of microsomal epoxide hydrolase with 16a, 17a-epoxyandrostene-3-one as substrate. Eur. Biochem. 126:425-431
    • (1982) Eur. Biochem. , vol.126 , pp. 425-431
    • Vogel-Bindel, U.1    Bentley, P.2    Oesch, F.3
  • 85
    • 0018185093 scopus 로고
    • Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticods. Demonstration of two groups within the enzyme_s activity towards twelve substrates
    • Wishart GJ (1978) Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticods. Demonstration of two groups within the enzyme_s activity towards twelve substrates. Biochem. J. 114:485-489
    • (1978) Biochem. J. , vol.114 , pp. 485-489
    • Wishart, G.J.1
  • 86
    • 0014798706 scopus 로고
    • Neonatal differences in the induction of hepatic aminolevulinic acid synthetase
    • Woods JS, Dixon RL (1970) Neonatal differences in the induction of hepatic aminolevulinic acid synthetase. Biochem. Pharmacol. 19:1951-1954
    • (1970) Biochem. Pharmacol. , vol.19 , pp. 1951-1954
    • Woods, J.S.1    Dixon, R.L.2
  • 87
    • 0017010907 scopus 로고
    • Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity
    • Woods JS (1976) Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity. Biochem. Pharmacol. 25:2147-2152
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 2147-2152
    • Woods, J.S.1
  • 88
    • 0014958933 scopus 로고
    • The presence of a monooxygenase system in human fetal liver microsomes
    • Yaffe SJ, Rane A, Sjöqvist F, Boreus LO, Orrenius S (1970) The presence of a monooxygenase system in human fetal liver microsomes. Life Sci 9, II, 1189-1200
    • (1970) Life Sci. , vol.9 , Issue.2 , pp. 1189-1200
    • Yaffe, S.J.1    Rane, A.2    Sjöqvist, F.3    Boreus, L.O.4    Orrenius, S.5
  • 89
    • 21344441619 scopus 로고    scopus 로고
    • Proc. of the 15th European Workshop on Drug Metabolism, Jena, Sept. 9-13, 1996
    • Fleck C, Klinger W (eds): Proc. of the 15th European Workshop on Drug Metabolism, Jena, Sept. 9-13, 1996, Exp. Toxic Path. 48, Suppl. II, 1-436, 1996
    • (1996) Exp. Toxic Path. , vol.48 , Issue.SUPPL. II , pp. 1-436
    • Fleck, C.1    Klinger, W.2
  • 91
    • 21344471574 scopus 로고    scopus 로고
    • Molecular investigation of metabolism and transport of drugs - From animal to human tissue
    • Nova Acta Leopoldina NF 87, Nr. 329
    • Fleck C, Klinger W, Muller D (eds.): Molecular Investigation of Metabolism and Transport of Drugs - From Animal to Human Tissue. Proc. of an European Symposium Halle September 27-29, 2001, Nova Acta Leopoldina NF 87, Nr. 329, 2003
    • (2003) Proc. of An European Symposium Halle September 27-29, 2001
    • Fleck, C.1    Klinger, W.2    Muller, D.3


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