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Volumn 25, Issue 1, 1997, Pages 47-54

Metabolites of nicotine in rat brain after peripheral nicotine administration: Cotinine, nornicotine, and norcotinine

Author keywords

[No Author keywords available]

Indexed keywords

COTININE; NICOTINE; NORNICOTINE;

EID: 0031030608     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (83)

References (44)
  • 1
    • 0011152843 scopus 로고
    • The metabolism of tobacco alkaloids
    • J. W. Gorrod and P. Jenner: The metabolism of tobacco alkaloids. Essays Toxicol. 6, 35-78 (1975).
    • (1975) Essays Toxicol. , vol.6 , pp. 35-78
    • Gorrod, J.W.1    Jenner, P.2
  • 3
    • 0006514594 scopus 로고
    • N-Oxidation, N-methylation and N-conjugation reactions of nicotine
    • (J. W. Gorrod and J. Wahren, eds.), Chapman Hall, London
    • P. A. Crooks: N-Oxidation, N-methylation and N-conjugation reactions of nicotine. In "Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion" (J. W. Gorrod and J. Wahren, eds.), pp. 81-109. Chapman Hall, London, 1993.
    • (1993) Nicotine and Related Alkaloids: Absorption, Distribution, Metabolism and Excretion , pp. 81-109
    • Crooks, P.A.1
  • 5
    • 0026643739 scopus 로고
    • Electron-impact and chemical ionization detection of nicotine and cotinine by gas chromatography-mass spectrometry in rat plasma and brain
    • J. Deutsch, L. Hegedus, N. H. Greig, S. I. Rapoport, and T. T. Soncrant: Electron-impact and chemical ionization detection of nicotine and cotinine by gas chromatography-mass spectrometry in rat plasma and brain. J. Chromatogr. 579, 93-98 (1992).
    • (1992) J. Chromatogr. , vol.579 , pp. 93-98
    • Deutsch, J.1    Hegedus, L.2    Greig, N.H.3    Rapoport, S.I.4    Soncrant, T.T.5
  • 7
    • 0021690270 scopus 로고
    • A comparative study of the disposition of nicotine and its metabolites in three inbred strains of mice
    • D. R. Peterson, K. J. Norris, and J. A. Thompson: A comparative study of the disposition of nicotine and its metabolites in three inbred strains of mice. Drug Metab. Dispos. 12, 725-731 (1984).
    • (1984) Drug Metab. Dispos. , vol.12 , pp. 725-731
    • Peterson, D.R.1    Norris, K.J.2    Thompson, J.A.3
  • 8
    • 0028824853 scopus 로고
    • Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: Detection of nornicotine
    • P. A. Crooks, M. Li, and L. P. Dwoskin: Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine. Drug Metab. Dispos. 23, 1175-1177 (1995).
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 1175-1177
    • Crooks, P.A.1    Li, M.2    Dwoskin, L.P.3
  • 9
    • 0027223255 scopus 로고
    • S(-)-Nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices
    • L. P. Dwoskin, S. T. Buxton, A. L. Jewell, and P. A. Crooks: S(-)-Nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices. J. Neurochem. 60, 2167-2174 (1993).
    • (1993) J. Neurochem. , vol.60 , pp. 2167-2174
    • Dwoskin, L.P.1    Buxton, S.T.2    Jewell, A.L.3    Crooks, P.A.4
  • 10
    • 0023840086 scopus 로고
    • Effects of stereoisomers of nicotine and nornicotine on schedule controlled responding and physiological parameters of dogs
    • M. E. Risner, E. J. Cone, N. L. Benowitz, and P. Jacob III: Effects of stereoisomers of nicotine and nornicotine on schedule controlled responding and physiological parameters of dogs. J. Pharmacol. Exp. Ther. 244, 807-813 (1988).
    • (1988) J. Pharmacol. Exp. Ther. , vol.244 , pp. 807-813
    • Risner, M.E.1    Cone, E.J.2    Benowitz, N.L.3    Jacob III, P.4
  • 12
    • 0027476650 scopus 로고
    • Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers
    • N. L. Benowitz and P. Jacob III: Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers. Clin. Pharmacol. Ther. 53, 316-323 (1993).
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 316-323
    • Benowitz, N.L.1    Jacob III, P.2
  • 13
    • 0028968934 scopus 로고
    • Dissociations between the locomotor stimulant and depressant effects of nicotine agonists in rats
    • I. P. Stolerman, H. S. Garcha, and N. R. Mizra: Dissociations between the locomotor stimulant and depressant effects of nicotine agonists in rats. Psychopharmacology 117, 430-437 (1995).
    • (1995) Psychopharmacology , vol.117 , pp. 430-437
    • Stolerman, I.P.1    Garcha, H.S.2    Mizra, N.R.3
  • 14
    • 0021076049 scopus 로고
    • 14C]-nicotine: Separation of enantiomers in a totally achiral system
    • 14C]-nicotine: separation of enantiomers in a totally achiral system. J. Chromatogr. 281, 17-23 (1983).
    • (1983) J. Chromatogr. , vol.281 , pp. 17-23
    • Cundy, K.C.1    Crooks, P.A.2
  • 16
    • 0020445076 scopus 로고
    • Resolution of (±)-5-bromonornicotine: Synthesis of (R)- and (S)-nornicotine of high enantiomeric purity
    • P. Jacob III: Resolution of (±)-5-bromonornicotine: synthesis of (R)-and (S)-nornicotine of high enantiomeric purity. J. Org. Chem. 47, 4165-4167 (1982).
    • (1982) J. Org. Chem. , vol.47 , pp. 4165-4167
    • Jacob III, P.1
  • 17
    • 0026745654 scopus 로고
    • Synthesis of N-glucuronic acid conjugates of cotinine, cis-3-hydroxycotinine and trans-3-hydroxycotinine
    • P. A. Crooks, B. S. Bhatti, A. Ravard, R. M. Riggs, and W. S. Caldwell: Synthesis of N-glucuronic acid conjugates of cotinine, cis-3-hydroxycotinine and trans-3-hydroxycotinine. Med. Sci. Res. 20, 881-883 (1992).
    • (1992) Med. Sci. Res. , vol.20 , pp. 881-883
    • Crooks, P.A.1    Bhatti, B.S.2    Ravard, A.3    Riggs, R.M.4    Caldwell, W.S.5
  • 18
    • 0021758565 scopus 로고
    • High performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine
    • K. C. Cundy and P. A. Crooks: High performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine. J. Chromatogr. Biomed. Appl. 306, 291-301 (1984).
    • (1984) J. Chromatogr. Biomed. Appl. , vol.306 , pp. 291-301
    • Cundy, K.C.1    Crooks, P.A.2
  • 19
    • 0024239936 scopus 로고
    • Species variation and stereoselectivity in the metabolism of nicotine enantiomers
    • C. G. Nwosu and P. A. Crooks: Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica 18, 1361-1372 (1988).
    • (1988) Xenobiotica , vol.18 , pp. 1361-1372
    • Nwosu, C.G.1    Crooks, P.A.2
  • 20
    • 0014866516 scopus 로고
    • Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice. Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice
    • T. Stalhandske: Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice. Effects of increased liver metabolism of nicotine on its uptake, elimination and toxicity in mice. Acta Physiol. Scand. 80, 222-234 (1970).
    • (1970) Acta Physiol. Scand. , vol.80 , pp. 222-234
    • Stalhandske, T.1
  • 21
    • 0342784611 scopus 로고
    • Detection of a long-lived nicotine metabolite in rat brain following peripheral nicotine administration
    • (P. B. S. Clark, M. Quik, K. Thurau, and F. Adlkofer, eds.), Birkhauser Verlag, Berlin
    • P. A. Crooks, M. Li, and L. P. Dwoskin: Detection of a long-lived nicotine metabolite in rat brain following peripheral nicotine administration. In "International Symposium on Nicotine: The Effects of Nicotine on Biological Systems. II" (P. B. S. Clark, M. Quik, K. Thurau, and F. Adlkofer, eds.), pp. 126. Birkhauser Verlag, Berlin, 1994.
    • (1994) International Symposium on Nicotine: The Effects of Nicotine on Biological Systems. II , pp. 126
    • Crooks, P.A.1    Li, M.2    Dwoskin, L.P.3
  • 22
    • 0038503121 scopus 로고
    • Recherches sur le metabolisme du tryptophane chez le rat soumis a l'intoxication chronique par la cotinine. Etude de l'elimination urinaire et dosage dans le cerveau et les intestins de certains derives inoliques
    • Paris
    • M. DeClercq and R. Truhaut: Recherches sur le metabolisme du tryptophane chez le rat soumis a l'intoxication chronique par la cotinine. Etude de l'elimination urinaire et dosage dans le cerveau et les intestins de certains derives inoliques. Bull. Soc. Chim. Biol. (Paris) 45, 995-1001 (1963).
    • (1963) Bull. Soc. Chim. Biol. , vol.45 , pp. 995-1001
    • DeClercq, M.1    Truhaut, R.2
  • 23
    • 0038164516 scopus 로고
    • Nicotine-related neurochemical changes: Some implications for motivational mechanisms and differences
    • (W. L. Dunn Jr., eds.), Winston and Sons, Washington, D.C.
    • W. B. Essman: Nicotine-related neurochemical changes: some implications for motivational mechanisms and differences. In "Smoking Behavior: Motives and Incentives" (W. L. Dunn Jr., eds.), pp. 51-65. Winston and Sons, Washington, D.C., 1973.
    • (1973) Smoking Behavior: Motives and Incentives , pp. 51-65
    • Essman, W.B.1
  • 24
    • 0024512721 scopus 로고
    • Nicotine and some related compounds: Effects on schedule controlled behavior and discriminative properties in rats
    • S. R. Goldberg, M. E. Risner, I. P. Stolerman, C. Reavill, and H. S. Garcha: Nicotine and some related compounds: effects on schedule controlled behavior and discriminative properties in rats. Psychopharmacology 97, 295-302 (1989).
    • (1989) Psychopharmacology , vol.97 , pp. 295-302
    • Goldberg, S.R.1    Risner, M.E.2    Stolerman, I.P.3    Reavill, C.4    Garcha, H.S.5
  • 27
    • 0025122350 scopus 로고
    • Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N′-propylnornicotine
    • Y. Zhang, P. Jacob III, and N. D. Benowitz: Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N′-propylnornicotine. J. Chromatogr. 525, 349-357 (1990).
    • (1990) J. Chromatogr. , vol.525 , pp. 349-357
    • Zhang, Y.1    Jacob III, P.2    Benowitz, N.D.3
  • 30
    • 0026066998 scopus 로고
    • A comparison of the binding of nicotine and nomicotine stereoisomers to nicotinic binding sites in rat brain cortex
    • J. R. Copeland, A. Adem, P. Jacob III, and A. Nordberg: A comparison of the binding of nicotine and nomicotine stereoisomers to nicotinic binding sites in rat brain cortex. Naunyn Schmeideberg's Arch. Pharmacol. 343, 123-127 (1991).
    • (1991) Naunyn Schmeideberg's Arch. Pharmacol. , vol.343 , pp. 123-127
    • Copeland, J.R.1    Adem, A.2    Jacob III, P.3    Nordberg, A.4
  • 31
    • 0027337239 scopus 로고
    • 3H)nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized
    • 3H)nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized. Naunyn Schmeideberg's Arch. Pharmacol. 348, 28-34 (1993).
    • (1993) Naunyn Schmeideberg's Arch. Pharmacol. , vol.348 , pp. 28-34
    • Zang, X.1    Nordberg, A.2
  • 32
    • 0021806045 scopus 로고
    • Effects of nicotine, cocaine and some of their metabolites on schedule controlled responding by beagle dogs and squirrel monkeys
    • M. E. Risner, S. R. Goldberg, J. A. Prada, and J. E. Cone: Effects of nicotine, cocaine and some of their metabolites on schedule controlled responding by beagle dogs and squirrel monkeys. J. Pharmacol. Exp. Ther. 234, 113-119 (1985).
    • (1985) J. Pharmacol. Exp. Ther. , vol.234 , pp. 113-119
    • Risner, M.E.1    Goldberg, S.R.2    Prada, J.A.3    Cone, J.E.4
  • 34
    • 0000021519 scopus 로고
    • Demethylation in the metabolism of (-)-nicotine
    • H. McKennis, L. B. Turnbull, and S. L. Schwartz: Demethylation in the metabolism of (-)-nicotine. J. Biol. Chem. 237, 541-545 (1962).
    • (1962) J. Biol. Chem. , vol.237 , pp. 541-545
    • McKennis, H.1    Turnbull, L.B.2    Schwartz, S.L.3
  • 35
    • 0015385918 scopus 로고
    • Cotinine-N-oxide, a new metabolite of nicotine
    • E. Dagne and N. Castagnioli: Cotinine-N-oxide, a new metabolite of nicotine. J. Med. Chem. 15, 840-841 (1972).
    • (1972) J. Med. Chem. , vol.15 , pp. 840-841
    • Dagne, E.1    Castagnioli, N.2
  • 36
    • 70449304068 scopus 로고
    • Metabolism of nicotine in the human and excretion of pyridine compounds in smokers
    • E. R. Bowman, L. B. Turnbull, and H. McKennis: Metabolism of nicotine in the human and excretion of pyridine compounds in smokers. J. Pharmacol Exp. Ther. 127, 91-102 (1959).
    • (1959) J. Pharmacol Exp. Ther. , vol.127 , pp. 91-102
    • Bowman, E.R.1    Turnbull, L.B.2    McKennis, H.3
  • 37
    • 0000373886 scopus 로고
    • Studies on the metabolism of (-)cotinine in the human
    • E. R. Bowman and H. McKennis: Studies on the metabolism of (-)cotinine in the human. J. Pharmacol. Exp. Ther. 135, 306-311 (1962).
    • (1962) J. Pharmacol. Exp. Ther. , vol.135 , pp. 306-311
    • Bowman, E.R.1    McKennis, H.2
  • 38
    • 0002628618 scopus 로고
    • Nicotine and metabolites: Analysis and levels in body fluids
    • (J. W. Gorrod and J. Wahren, eds.), Chapman Hall, London
    • M. Curvall and E. Kazemi Vala: Nicotine and metabolites: analysis and levels in body fluids. In "Nicotine and Related Alkaloids: Absorption, Metabolism, Excretion" (J. W. Gorrod and J. Wahren, eds.), pp. 147-179. Chapman Hall, London, 1993.
    • (1993) Nicotine and Related Alkaloids: Absorption, Metabolism, Excretion , pp. 147-179
    • Curvall, M.1    Kazemi Vala, E.2
  • 39
  • 40
    • 0026620552 scopus 로고
    • In vitro studies on (-)-(S)-nornicotine
    • G. Aislaitner, Y. Li, and J. W. Gorrod: In vitro studies on (-)-(S)-nornicotine. Med. Sci. Res. 20, 897-899 (1992).
    • (1992) Med. Sci. Res. , vol.20 , pp. 897-899
    • Aislaitner, G.1    Li, Y.2    Gorrod, J.W.3
  • 41
    • 0342349549 scopus 로고
    • Norcotinine (desmethylcotinine) as a urinary metabolite of nornicotine
    • E. Wada, E. R. Bowman, and L. B. Turnbull: Norcotinine (desmethylcotinine) as a urinary metabolite of nornicotine. J. Med. Pharm. Chem. 4, 21-30 (1961).
    • (1961) J. Med. Pharm. Chem. , vol.4 , pp. 21-30
    • Wada, E.1    Bowman, E.R.2    Turnbull, L.B.3
  • 42
    • 0012355780 scopus 로고
    • Formation of nornicotine and other metabolites from nicotine in vitro and in vivo
    • N. Papadopoulos: Formation of nornicotine and other metabolites from nicotine in vitro and in vivo. Can. J. Chem. 42, 435-442 (1964).
    • (1964) Can. J. Chem. , vol.42 , pp. 435-442
    • Papadopoulos, N.1
  • 44
    • 0028174713 scopus 로고
    • N-Hydroxymethylnorcotinine, a new primary in vitro metabolite of cotinine
    • Y. Li and J. W. Gorrod: N-Hydroxymethylnorcotinine, a new primary in vitro metabolite of cotinine. Xenobiotica 24, 409-415 (1994).
    • (1994) Xenobiotica , vol.24 , pp. 409-415
    • Li, Y.1    Gorrod, J.W.2


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