The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation

FEBS Journal

Volumn 281, Issue 16, 2014, Pages 3591-3608

  Jones, David R ^a   Keune, Willem Jan ^a   Anderson, Karen E ^b   Stephens, Len R ^b   Hawkins, Phillip T ^b   Divecha, Nullin ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

glucose; insulin; oxidative stress; protein kinase B; Signalling

Indexed keywords

GLUCOSAMINE; GLUCOSE; HEXOSAMINE; HYDROGEN PEROXIDE; INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; N ACETYLGLUCOSAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ACYLATION; ARTICLE; BIOSYNTHESIS; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR SPACE; GLUCOSE TRANSPORT; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL;

GLUCOSE; INSULIN; OXIDATIVE STRESS; PROTEIN KINASE B; SIGNALLING;

ACETYLGLUCOSAMINE; BIOSYNTHETIC PATHWAYS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENERGY METABOLISM; ENZYME ACTIVATION; GLUCOSE; GLYCOSYLATION; HEXOSAMINES; HUMANS; HYDROGEN PEROXIDE; INSULIN; MULTIPROTEIN COMPLEXES; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84906790178     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12879     Document Type: Article

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