Protein O-GlcNAcylation regulates Drosophila growth through the insulin signaling pathway

Cellular and Molecular Life Sciences

Volumn 68, Issue 20, 2011, Pages 3377-3384

  Park, Sujin ^a   Park, Si Hyoung ^a   Baek, Ju Yuel ^a   Jy, Ye Jin ^a   Kim, Kwan Soo ^a   Roth, Jürgen ^a   Cho, Jin Won ^a   Choe, Kwang Min ^a  

^a Yonsei University   (South Korea)

Author keywords

Drosophila; Insulin; O GlcNAcase; OGT; Size control

Indexed keywords

INSULIN; N ACETYLGLUCOSAMINE; PROTEIN KINASE B;

ACYLATION; ANIMAL TISSUE; ARTICLE; BODY GROWTH; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; BODY COMPOSITION; CELL PROLIFERATION; DROSOPHILA; GLYCOSYLATION; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INSULIN; N-ACETYLGLUCOSAMINYLTRANSFERASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 80054744483     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0640-7     Document Type: Article

References (28)

1. GW Hart MP Housley C Slawson 2007 Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins Nature 446 1017 1022 17460662 10.1038/nature05815 1:CAS:528:DC%2BD2sXksFersr4%3D (Pubitemid 46676063)
2. JA Hanover ME Forsythe PT Hennessey TM Brodigan DC Love G Ashwell M Krause 2005 A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout Proc Natl Acad Sci USA 102 11266 11271 16051707 10.1073/pnas.0408771102 1:CAS:528: DC%2BD2MXoslKitrY%3D (Pubitemid 41153809)
3. ME Forsythe DC Love BD Lazarus EJ Kim WA Prinz G Ashwell MW Krause JA Hanover 2006 Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer Proc Natl Acad Sci USA 103 11952 11957 16882729 10.1073/pnas.0601931103 1:CAS:528:DC%2BD28XosVSgsbs%3D (Pubitemid 44215792)
4. R Shafi SP Iyer LG Ellies N O'Donnell KW Marek D Chui GW Hart JD Marth 2000 The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny Proc Natl Acad Sci USA 97 5735 5739 10801981 10.1073/pnas.100471497 1:CAS:528:DC%2BD3cXjvFaktrY%3D (Pubitemid 30367467)
5. N O'Donnell NE Zachara GW Hart JD Marth 2004 Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability Mol Cell Biol 24 1680 1690 14749383 10.1128/MCB.24.4.1680-1690.2004 (Pubitemid 38167089)
6. DA McClain WA Lubas RC Cooksey M Hazel GJ Parker DC Love JA Hanover 2002 Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia Proc Natl Acad Sci USA 99 10695 10699 12136128 10.1073/pnas.152346899 1:CAS:528:DC%2BD38Xmt1Chtro%3D
7. X Yang PP Ongusaha PD Miles JC Havstad F Zhang WV So JE Kudlow RH Michell JM Olefsky SJ Field RM Evans 2008 Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance Nature 451 964 969 18288188 10.1038/nature06668 1:CAS:528:DC%2BD1cXit1yns74%3D (Pubitemid 351301737)
8. JC Gandy AE Rountree GN Bijur 2006 Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1 FEBS Lett 580 3051 3058 16684529 10.1016/j.febslet.2006.04.051 1:CAS:528: DC%2BD28XltVKnur0%3D (Pubitemid 43729656)
9. M Kuo V Zilberfarb N Gangneux N Christeff T Issad 2008 O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene FEBS Lett 582 829 834 18280254 10.1016/j.febslet.2008.02.010 1:CAS:528:DC%2BD1cXisVSqtLg%3D
10. ES Kang D Han J Park TK Kwak MA Oh SA Lee S Choi ZY Park Y Kim JW Lee 2008 O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells Exp Cell Res 314 2238 2248 18570920 10.1016/j.yexcr.2008. 04.014 1:CAS:528:DC%2BD1cXns1Smt7c%3D (Pubitemid 351833109)
11. MC Gambetta K Oktaba J Muller 2009 Essential role of the glycosyltransferase sxc/Ogt in Polycomb repression Science 325 93 96 19478141 10.1126/science.1169727 1:CAS:528:DC%2BD1MXnvF2kt70%3D
12. DA Sinclair M Syrzycka MS Macauley T Rastgardani I Komljenovic DJ Vocadlo HW Brock BM Honda 2009 Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc) Proc Natl Acad Sci USA 106 13427 13432 19666537 10.1073/pnas.0904638106 1:CAS:528:DC%2BD1MXhtVOitr3E
13. O Puig MT Marr ML Ruhf R Tjian 2003 Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway Genes Dev 17 2006 2020 12893776 10.1101/gad.1098703 1:CAS:528:DC%2BD3sXms1Kntrw%3D (Pubitemid 36999327)
14. KS Lee OY Kwon JH Lee K Kwon KJ Min SA Jung AK Kim KH You M Tatar K Yu 2008 Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling Nat Cell Biol 10 468 475 18344986 10.1038/ncb1710 1:CAS:528:DC%2BD1cXktVGqtrg%3D
15. JG Kang SY Park S Ji I Jang S Park HS Kim SM Kim JI Yook YI Park J Roth JW Cho 2009 O-GlcNAc protein modification in cancer cells increases in response to glucose deprivation through glycogen degradation J Biol Chem 284 34777 34784 19833729 10.1074/jbc.M109.026351 1:CAS:528:DC%2BD1MXhsFWitLfF
16. MS Macauley GE Whitworth AW Debowski D Chin DJ Vocadlo 2005 O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors J Biol Chem 280 25313 25322 15795231 10.1074/jbc.M413819200 1:CAS:528:DC%2BD2MXlslyltL4%3D (Pubitemid 40962233)
17. DR Marenda AD Vrailas AB Rodrigues S Cook MA Powers JA Lorenzen LA Perkins K Moses 2006 MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing Development 133 43 51 16308331 10.1242/dev.02168 1:CAS:528:DC%2BD28XhtFGgtbo%3D (Pubitemid 43169319)
18. SY Yu SJ Yoo L Yang C Zapata A Srinivasan BA Hay NE Baker 2002 A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye Development 129 3269 3278 12070100 1:CAS:528:DC%2BD38XlsFGht7k%3D (Pubitemid 34874299)
19. G Struhl K Basler 1993 Organizing activity of wingless protein in Drosophila Cell 72 527 540 8440019 10.1016/0092-8674(93)90072-X 1:CAS:528:DyaK3sXitlSmtLo%3D (Pubitemid 23077741)
20. RS Garofalo 2002 Genetic analysis of insulin signaling in Drosophila Trends Endocrinol Metab 13 156 162 11943559 10.1016/S1043-2760(01)00548-3 1:CAS:528:DC%2BD38Xjs1Kmt7c%3D (Pubitemid 36733989)
21. S Kane H Sano SC Liu JM Asara WS Lane CC Garner GE Lienhard 2002 A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain J Biol Chem 277 22115 22118 11994271 10.1074/jbc.C200198200 1:CAS:528:DC%2BD38XltVGksrk%3D (Pubitemid 34967174)
22. SY Park J Ryu W Lee 2005 O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes Exp Mol Med 37 220 229 16000877 1:CAS:528: DC%2BD2MXmt1yqtbc%3D (Pubitemid 40992738)
23. Sekine O, Love DC, Rubenstein DS, Hanover JA (2010) Blocking O-GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis. J Biol Chem. doi: 10.1074/jbc.M110.155192
24. J Verdu MA Buratovich EL Wilder MJ Birnbaum 1999 Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB Nat Cell Biol 1 500 506 10587646 10.1038/70293 1:CAS:528:DyaK1MXotFalur4%3D (Pubitemid 129503670)
25. WH Yang JE Kim HW Nam JW Ju HS Kim YS Kim JW Cho 2006 Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability Nat Cell Biol 8 1074 1083 16964247 10.1038/ncb1470 1:CAS:528:DC%2BD28XhtVWqsLbN (Pubitemid 44473602)
26. WH Yang SY Park S Ji JG Kang JE Kim H Song I Mook-Jung KM Choe JW Cho 2010 O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation Biochem Biophys Res Commun 391 756 761 19944066 10.1016/j.bbrc.2009.11.133 1:CAS:528:DC%2BC3cXpsVyg
27. C Toleman AJ Paterson TR Whisenhunt JE Kudlow 2004 Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities J Biol Chem 279 53665 53673 15485860 10.1074/jbc.M410406200 1:CAS:528:DC%2BD2cXhtVKqu73O (Pubitemid 40051874)
28. ME Patti A Virkamaki EJ Landaker CR Kahn H Yki-Jarvinen 1999 Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle Diabetes 48 1562 1571 10426374 10.2337/diabetes.48.8.1562 1:CAS:528:DyaK1MXkvVKnu7k%3D (Pubitemid 29356864)