Evolutionary analysis identifies an MX2 haplotype associated with natural resistance to HIV-1 infection

Molecular Biology and Evolution

Volumn 31, Issue 9, 2014, Pages 2402-2414

  Sironi, Manuela ^a   Biasin, Mara ^b   Cagliani, Rachele ^a   Gnudi, Federica ^b   Saulle, Irma ^b   Ibba, Salomè ^b   Filippi, Giulia ^c   Yahyaei, Sarah ^b   Tresoldi, Claudia ^a   Riva, Stefania ^a   Trabattoni, Daria ^b   De Gioia, Luca ^c   Caputo, Sergio Lo ^d   Mazzotta, Francesco ^d   Forni, Diego ^a   Pontremoli, Chiara ^a   Pineda, Juan Antonio ^e   Pozzoli, Uberto ^a   Rivero Juarez, Antonio ^f   Caruz, Antonio ^g   Clerici, Mario ^b,h   more..

^a SCIENTIFIC INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^e HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^f UNIVERSITY OF CÓRDOBA   (Spain)

^g UNIVERSITY OF JAÉN   (Spain)

^h IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Adaptive evolution; HIV 1 infection; MX2; Positive selection

Indexed keywords

ALPHA INTERFERON; MX2 PROTEIN, HUMAN; MYXOVIRUS RESISTANCE PROTEIN;

ALLELE; ALPHA HELIX; ANCESTRY GROUP; ARTICLE; ASIAN; CONTROLLED STUDY; EUROPEAN; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GEOGRAPHIC ORIGIN; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; INTRON; MAJOR CLINICAL STUDY; MALE; MELANOMA; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; MYXOVIRUS RESISTANCE 2 GENE; NATURAL POPULATION; NATURAL SELECTION; NONHUMAN; POPULATION EXPOSURE; POPULATION GENETICS; PROTEIN DOMAIN; RECESSIVE INHERITANCE; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS GENE; VIRUS REPLICATION; VIRUS RESISTANCE; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGICAL MODEL; BIOLOGY; CAUCASIAN; CHEMISTRY; DISEASE RESISTANCE; GENETIC SELECTION; GENETIC VARIATION; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; PATHOGENICITY; PHYLOGENY; PROCEDURES;

ASIAN CONTINENTAL ANCESTRY GROUP; COMPUTATIONAL BIOLOGY; DISEASE RESISTANCE; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION, MOLECULAR; GENETIC VARIATION; HAPLOTYPES; HIV INFECTIONS; HIV-1; HUMANS; MODELS, GENETIC; MYXOVIRUS RESISTANCE PROTEINS; PHYLOGENY; SELECTION, GENETIC;

EID: 84906748712     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu193     Document Type: Article

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