Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA

Cell Host and Microbe

Volumn 12, Issue 4, 2012, Pages 598-604

  Mitchell, Patrick S ^a,b   Patzina, Corinna ^d,e   Emerman, Michael ^b   Haller, Otto ^d   Malik, Harmit S ^b,c   Kochs, Georg ^d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

^e International Max Planck Research School for Molecular and Cellular Biology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DYNAMIN; INTERFERON; MYXOVIRUS RESISTANCE PROTEIN A;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLUENZA A; NONHUMAN; ORTHOMYXOVIRUS; PRIMATE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; EVOLUTION, MOLECULAR; GTP-BINDING PROTEINS; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS; MOLECULAR SEQUENCE DATA; PHYLOGENY; PRIMATES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; THOGOTOVIRUS;

EID: 84867659115     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.09.005     Document Type: Article

References (21)

1. S. Berlin, L. Qu, X. Li, N. Yang, and H. Ellegren Positive diversifying selection in avian Mx genes Immunogenetics 60 2008 689 697
2. M.D. Daugherty, and H.S. Malik Rules of engagement: molecular insights from host-virus arms races Annu. Rev. Genet. 46 2012 in press. Published online November 2, 2012 (expected). 10.1146/annurev-genet-110711-155522
3. J. Dittmann, S. Stertz, D. Grimm, J. Steel, A. García-Sastre, O. Haller, and G. Kochs Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase J. Virol. 82 2008 3624 3631 (Pubitemid 351429938)
4. S. Gao, A. von der Malsburg, A. Dick, K. Faelber, G.F. Schröder, O. Haller, G. Kochs, and O. Daumke Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function Immunity 35 2011 514 525
5. O. Haller, and G. Kochs Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity J. Interferon Cytokine Res. 31 2011 79 87
6. O. Haller, M. Frese, D. Rost, P.A. Nuttall, and G. Kochs Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1 J. Virol. 69 1995 2596 2601
7. O. Haller, S. Gao, A. von der Malsburg, O. Daumke, and G. Kochs Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity J. Biol. Chem. 285 2010 28419 28424
8. G. Kochs, and O. Haller GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae) J. Biol. Chem. 274 1999 4370 4376
9. H. Landis, A. Simon-Jödicke, A. Klöti, C. Di Paolo, J.J. Schnorr, S. Schneider-Schaulies, H.P. Hefti, and J. Pavlovic Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins J. Virol. 72 1998 1516 1522 (Pubitemid 28116940)
10. N. Li, L. Zhang, L. Chen, W. Feng, Y. Xu, F. Chen, X. Liu, Z. Chen, and W. Liu MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen Hepatology 56 2012 803 811
11. C.L. Netherton, J. Simpson, O. Haller, T.E. Wileman, H.H. Takamatsu, P. Monaghan, and G. Taylor Inhibition of a large double-stranded DNA virus by MxA protein J. Virol. 83 2009 2310 2320
12. P. Perelman, W.E. Johnson, C. Roos, H.N. Seuánez, J.E. Horvath, M.A. Moreira, B. Kessing, J. Pontius, M. Roelke, and Y. Rumpler A molecular phylogeny of living primates PLoS Genet. 7 2011 e1001342
13. F. Pitossi, A. Blank, A. Schröder, A. Schwarz, P. Hüssi, M. Schwemmle, J. Pavlovic, and P. Staeheli A functional GTP-binding motif is necessary for antiviral activity of Mx proteins J. Virol. 67 1993 6726 6732 (Pubitemid 23309141)
14. A. Ponten, C. Sick, M. Weeber, O. Haller, and G. Kochs Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity J. Virol. 71 1997 2591 2599 (Pubitemid 27119894)
15. M. Reichelt, S. Stertz, J. Krijnse-Locker, O. Haller, and G. Kochs Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes Traffic 5 2004 772 784 (Pubitemid 39307261)
16. S.L. Sawyer, L.I. Wu, M. Emerman, and H.S. Malik Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain Proc. Natl. Acad. Sci. USA 102 2005 2832 2837 (Pubitemid 40299877)
17. A. von der Malsburg, I. Abutbul-Ionita, O. Haller, G. Kochs, and D. Danino Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop J. Biol. Chem. 286 2011 37858 37865
18. F. Weber, O. Haller, and G. Kochs MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes J. Virol. 74 2000 560 563 (Pubitemid 30002942)
19. C. Wisskirchen, T.H. Ludersdorfer, D.A. Müller, E. Moritz, and J. Pavlovic Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49 J. Biol. Chem. 286 2011 34743 34751
20. Z. Yang PAML 4: phylogenetic analysis by maximum likelihood Mol. Biol. Evol. 24 2007 1586 1591 (Pubitemid 47236688)
21. P. Zimmermann, B. Mänz, O. Haller, M. Schwemmle, and G. Kochs The viral nucleoprotein determines Mx sensitivity of influenza A viruses J. Virol. 85 2011 8133 8140