A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus

Immunogenetics

Volumn 66, Issue 1, 2014, Pages 25-32

  Sasaki, Keisuke ^a   Tungtrakoolsub, Pullop ^a   Morozumi, Takeya ^b   Uenishi, Hirohide ^c   Kawahara, Manabu ^a   Watanabe, Tomomasa ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Institute of Japan Association for Techno innovation in Agriculture   (Japan)

^c NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

Author keywords

Antiviral activity; Mismatched PCR RFLP; MX2; Pig; SNP; Vesicular stomatitis virus

Indexed keywords

ARGININE; GLUTAMINE; GLYCINE; GREEN FLUORESCENT PROTEIN; HISTIDINE; ISOLEUCINE; PHENYLALANINE; SERINE; THREONINE; TRANSCRIPTION FACTOR EMX2; TRYPTOPHAN; VALINE;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; INFLUENZA VIRUS; LIVESTOCK; MOLECULAR CLONING; MONONUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; VESICULAR STOMATITIS VIRUS;

ANIMALIA; ORTHOMYXOVIRIDAE; SUIDAE; SUS; VESICULAR STOMATITIS VIRUS;

EID: 84891831760     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-013-0745-2     Document Type: Article

References (30)

1. Aebi M, Fah J, Hurt N, Samuel CE, Thomis D, Bazzigher L, Pavlovic J, Haller O, Staeheli P (1989) cDNA structures and regulation of two interferon-induced human Mx proteins. Mol Cell Biol 9:5062-5072
2. Arnold K, Bordoli L, Kopp J, Schwede T (2006) The SWISS-MODEL workspace: a web-based environment for protein structure homology modeling. Bioinformatics 2:195-201
3. Asano A, Ko JH, Morozumi T, Hamashima N, Watanabe T (2002) Polymorphisms and the antiviral property of porcine Mx1 protein. J Vet Med Sci 64:1085-1089
4. Ewald SJ, Kapczynski DR, Livant EJ, Suarez DL, Ralph J, McLeod S, Miller C (2011) Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus. Immunogenetics 63:363-375
5. Flohr F, Schneider-Schaulies S, Haller O, Kochs G (1999) The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures. FEBS Lett 463:24-28
6. Frese M, Kochs G, Feldmann H, Hertkorn C, Haller O (1996) Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J Virol 70:915-923
7. Gao S, von der Malsburg A, Paeschke S, Behlke J, Haller O, Kochs G, Daumke O (2010) Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature 465:502-506
8. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 15:2714-2723
9. Haller O, Kochs G (2002) Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity. Traffic 3:710-717
10. Horisberger MA, Staeheli P, Haller O (1983) Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A 80:1910-1914
11. Jin HK, Takada A, Kon Y, Haller O, Watanabe T (1999) Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. J Virol 73:4925-4930
12. Jin HK, Yamashita T, Ochiai K, Haller O, Watanabe T (1998) Characterization and expression of the Mx1 gene in wild mouse species. Biochem Genet 36:311-322
13. Kanerva M, Melen K, Vaheri A, Julkunen I (1996) Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein. Virology 224:55-62
14. Ko JH, Jin HK, Asano A, Takada A, Ninomiya A, Kida H, Hokiyama H, Ohara M, Tsuzuki M, Nishibori M, Mizutani M, Watanabe T (2002) Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res 12:595-601
15. Landis H, Simon-Jodicke A, Kloti A, Di Paolo C, Schnorr JJ, Schneider-Schaulies S, Hefti HP, Pavlovic J (1998) Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins. J Virol 72:1516-1522
16. Lindenmann J (1964) Inheritance of resistance to influenza virus in mice. Proc Soc Exp Biol Med 116:506-509
17. Morozumi T, Naito T, Lan PD, Nakajima E, Mitsuhashi T, Mikawa S, Hayashi T, Awata T, Uenishi H, Nagata K, Watanabe T, Hamasima N (2009) Molecular cloning and characterization of porcine Mx2 gene. Mol Immunol 46:858-865
18. Nakajima E, Morozumi T, Tsukamoto K, Watanabe T, Plastow G, Mitsuhashi T (2007) A naturally occurring variant of porcine Mx1 associated with increased susceptibility to influenza virus in vitro. Biochem Genet 45:11-24
19. Nakayama M, Yazaki K, Kusano A, Nagata K, Hanai N, Ishihama A (1993) Structure of mouse Mx1 protein. Molecular assembly and GTP-dependent conformational change. J Biol Chem 268:15033-15038
20. Pitossi F, Blank A, Schroder A, Schwarz A, Hussi P, Schwemmle M, Pavlovic J, Staeheli P (1993) A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. J Virol 67:6726-6732
21. Sasaki K, Yoneda A, Ninomiya A, Kawahara M, Watanabe T (2013) Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631. Biochem Biophys Res Commun 430:161-166
22. Schneider-Schaulies S, Schneider-Schaulies J, Schuster A, Bayer M, Pavlovic J, ter Meulen V (1994) Cell type-specific MxA-mediated inhibition of measles virus transcription in human brain cells. J Virol 68:6910-6917
23. Schumacher B, Staeheli P (1998) Domains mediating intramolecular folding and oligomerization of MxA GTPase. J Biol Chem 273:28365-28370
24. Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 13:3381-3385
25. Schwemmle M, Richter MF, Herrmann C, Nassar N, Staeheli P (1995) Unexpected structural requirements for GTPase activity of the interferon-induced MxA protein. J Biol Chem 270:13518-13523
26. Sironi L, Williams JL, Moreno-Martin AM, Ramelli P, Stella A, Jianlin H, Weigend S, Lombardi G, Cordioli P, Mariani P (2008) Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631. Virology 380:152-156
27. Staeheli P, Sutcliffe JG (1988) Identification of a second interferon-regulated murine Mx gene. Mol Cell Biol 8:4524-4528
28. Takada A, Robison C, Goto H, Sanchez A, Murti KG, Whitt MA, Kawaoka Y (1997) A system for functional analysis of Ebola virus glycoprotein. Proc Natl Acad Sci U S A 94:14764-14769
29. Zhao H, De BP, Das T, Banerjee AK (1996) Inhibition of human parainfluenza virus-3 replication by interferon and human MxA. Virology 220:330-338
30. Zurcher T, Pavlovic J, Staeheli P (1992) Mechanism of human MxA protein action: variants with changed antiviral properties. EMBO J 11:1657-1661