A genetic polymorphism of FREM1 is associated with resistance against HIV infection in the pumwani sex worker cohort

Journal of Virology

Volumn 86, Issue 21, 2012, Pages 11899-11905

  Luo, Ma ^a,b   Sainsbury, Jamse ^a,b   Tuff, Jeffrey ^a   Lacap, Philip A ^a   Yuan, Xin Yong ^a   Hirbod, Taha ^c   Kimani, Joshua ^d   Wachihi, Charles ^d   Ramdahin, Sue ^b   Bielawny, Thomas ^a   Embree, Joanne ^b   Broliden, Kristina ^c   Ball, T Blake ^a,b   Plummera, Francis A ^a,b  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

FREM1 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ALLELE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DNA POLYMORPHISM; ECTOCERVICAL MUCOSA; EXPLORATORY RESEARCH; FEMALE; FREM1 GENE; GENE; GENETIC ASSOCIATION; GENOTYPE; HEREDITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRON; MAJOR CLINICAL STUDY; MOTHER CHILD RELATION; PHENOTYPE; PRIORITY JOURNAL; PROSTITUTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; UTERINE CERVIX MUCOSA; VIRUS RESISTANCE;

ADULT; CERVIX UTERI; COHORT STUDIES; DISEASE RESISTANCE; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION STUDIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, MUCOSAL; IMMUNOHISTOCHEMISTRY; KENYA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN; SEX WORKERS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84869062784     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01499-12     Document Type: Article

References (52)

1. Alimonti JB, et al. 2006. Characterization of CD8 T-cell responses in HIV-1-exposed seronegative commercial sex workers from Nairobi, Kenya. Immunol. Cell Biol. 84:482-485.
2. Alimonti JB, et al. 2005. CD4+T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women. J. Infect. Dis. 191:20-24.
3. Amundadottir LT, et al. 2006. A common variant associated with prostate cancer in European and African populations. Nat. Genet. 38:652-658.
4. Arthos J, et al. 2008. HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells. Nat. Immunol. 9:301-309.
5. Ball TB, et al. 2007. Polymorphisms in IRF-1 associated with resistance to HIV-1 infection in highly exposed uninfected Kenyan sex workers. AIDS 21:1091-1101.
6. Ballana E, et al. 2011. β5 Integrin is the major contributor to the αV integrin-mediated blockade of HIV-1 replication. J. Immunol. 186:464-470.
7. Ballana E, et al. 2009. Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages. Blood 113:1278-1286.
8. Barrett JC, et al. 2008. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40:955-962.
9. Braddick MR, et al. 1990. Impact of maternal HIV infection on obstetrical and early neonatal outcome. AIDS 4:1001-1005.
10. Budde ML, Lhost JJ, Dudley DM, Rakasz EG, O'Connor DH. 2010. Integrin alpha4beta7 is downregulated on the surfaces of simian immunodeficiency virus SIVmac239-infected cells. J. Virol. 84:6344-6351.
11. Burgener A, et al. 2008. Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers. J. Proteome Res. 7:4446-4454.
12. Card CM, et al. 2009. Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells. J. Infect. Dis. 199:1318-1322.
13. Cicala C, Arthos J, Fauci AS. 2011. HIV-1 envelope, integrins and coreceptor use in mucosal transmission of HIV. J. Transl. Med. 9(Suppl 1):S2.
14. Cicala C, et al. 2009. The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Proc. Natl. Acad. Sci. U.S.A. 106:20877-20882.
15. Fowke KR, et al. 1996. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 348:1347-1351.
16. Hardie RA, et al. 2008. A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers. AIDS 22:2038 -2042.
17. Hardie RA, et al. 2008. Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection. AIDS 22:807-816.
18. Herbert A, et al. 2006. A common genetic variant is associated with adult and childhood obesity. Science 312:279 -283.
19. Hirbod T, et al. 2006. Upregulation of interferon-α and RANTES in the Cervix of HIV-1-seronegative women with high-risk behavior. J. Acquired Immune Defic. Syndr. 43:137-143.
20. Hladik F, Hope TJ. 2009. HIV infection of the genital mucosa in women. Curr. HIV/AIDS Rep. 6:20-28.
21. Iqbal SM, et al. 2005. Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1-resistant Kenyan commercial sex workers. J. Infect. Dis. 192:728 -738.
22. Iqbal SM, et al. 2009. Elevated elafin/trappin-2 in the female genital tract is associated with protection against HIV acquisition. AIDS 23:1669-1677.
23. Kaul R, et al. 2001. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Investig. 107:1303-1310.
24. Kaul R, et al. 2000. HIV-1-specific mucosal CD8+lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J. Immunol. 164: 1602-1611.
25. Kaul R, et al. 2001. New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers. Immunol. Lett. 79:3-13.
26. Kiyozumi D, et al. 2005. Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp. Cell Res. 306:9-23.
27. Kreiss JK, et al. 1986. AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa. N. Engl. J. Med. 314:414-418.
28. Lacap PA, et al. 2008. Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani sex worker cohort. AIDS 22:1029 -1038.
29. Lore K, Andersson J. 2004. Detection of cytokine- and chemokineexpressing cells at the single cell level. Methods Mol. Biol. 249:201-218.
30. Luo M, et al. 2012. For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection. J. Virol. 86:1166 -1180.
31. Marchini J, Cardon LR, Phillips MS, Donnelly P. 2004. The effects of human population structure on large genetic association studies. Nat. Genet. 36:512-517.
32. McLaren PJ, et al. 2010. HIV-exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors. J. Infect. Dis. 202: S339-S344.
33. Nawaz F, et al. 2011. The genotype of early-transmitting HIV gp120s promotes alpha (4) beta(7)-reactivity, revealing alpha (4) beta(7) +/CD4+T cells as key targets in mucosal transmission. PLoS 7:e1001301. doi:10.1371/journal.ppat.1001301.
34. Piot P, et al. 1987. Heterosexual transmission of HIV. AIDS 1:199 -206.
35. Piot P, et al. 1988. AIDS: an international perspective. Science 239:573-579.
36. Piot P, et al. 1987. Retrospective seroepidemiology of AIDS virus infection in Nairobi populations. J. Infect. Dis. 155:1108-1112.
37. Plummer FA, et al. 1983. Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. Lancet ii:1293-1295.
38. Plummer FA, et al. 1985. Clinical and microbiologic studies of genital ulcers in Kenyan women. Sex Transm. Dis. 12:193-197.
39. Plummer FA, et al. 1987. Postpartum upper genital tract infections in Nairobi, Kenya: epidemiology, etiology, and risk factors. J. Infect. Dis. 156:92-98.
40. Plummer FA, et al. 1984. Cefotaxime treatment of Haemophilus ducreyi infection in Kenya. Sex Transm. Dis. 11:304 -307.
41. Price H, et al. 2010. A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort. AIDS 24:1813-1821.
42. Rabbee N, Speed TP. 2006. A genotype calling algorithm for Affymetrix SNP arrays. Bioinformatics 22:7-12.
43. Reeves RK, Evans TI, Gillis J, Johnson RP. 2010. Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56+ NK cells. J. Virol. 84:8959-8963.
44. Ronald A, et al. 1991. The Nairobi STD program. An international partnership. Infect. Dis. Clin. N. Am. 5:337-352.
45. Ronald AR, Plummer FA. 1985. Chancroid and Haemophilus ducreyi. Ann. Intern. Med. 102:705-707.
46. Rowland-Jones SL, et al. 1998. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Investig. 102:1758-1765.
47. Samson M, et al. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722-725.
48. Simonsen JN, et al. 1990. HIV infection among lower socioeconomic strata prostitutes in Nairobi. AIDS 4:139 -144.
49. Smyth I, et al. 2004. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc. Natl. Acad. Sci. U.S.A. 101:13560-13565.
50. Trivedi HN, et al. 2001. Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production. FASEB J. 15:1795-1797.
51. Wang X, et al. 2009. Monitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection. Mucosal Immunol. 2:518-526.
52. Zhang X, et al. 2010. TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NFkappaB. J. Biol. Chem. 285:7222-7232.