Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12462-12467

  Cheng, Allen A ^a,b,c   Ding, Huiming ^d   Lu, Timothy K ^a,e  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Building C 2   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

Combination therapy; Drug resistance; Multifactorial genetics; Synthetic biology; Systems biology

Indexed keywords

ANHYDROTETRACYCLINE; ANTIBIOTIC AGENT; CEFTRIAXONE; GENTAMICIN; IMIPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; PIPERACILLIN PLUS TAZOBACTAM; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA-LACTAMASE NDM-1; CARBAPENEM DERIVATIVE; ESCHERICHIA COLI PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERICIDAL ACTIVITY; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; COMBINATORIAL GENETICS; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ESCHERICHIA COLI; GENE OVEREXPRESSION; HIGH THROUGHPUT SEQUENCING; MINIMUM INHIBITORY CONCENTRATION; NEXT GENERATION SEQUENCING; NONHUMAN; PHAGEMID; PHENOTYPE; PRIORITY JOURNAL; DNA BARCODING; DRUG EFFECTS; ENZYMOLOGY; GENE LIBRARY; GENETIC PROCEDURES; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY;

BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; DNA BARCODING, TAXONOMIC; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE LIBRARY; GENES, BACTERIAL; GENETIC TECHNIQUES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY; TRANSCRIPTION FACTORS;

EID: 84906678385     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400093111     Document Type: Article

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