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Volumn 6, Issue AUG, 2014, Pages

Cyclin-dependent kinase 5, a node protein in diminished tauopathy: A systems biology approach

Author keywords

Alzheimer's disease; CDK5; GSK3 ; phosphotases; Tauopathy

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN; CALCIUM IONOPHORE; N METHYL DEXTRO ASPARTIC ACID; PHOSPHATASE; PHOSPHOTRANSFERASE;

EID: 84906235569     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00232     Document Type: Article
Times cited : (28)

References (91)
  • 1
    • 0035968240 scopus 로고    scopus 로고
    • Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2
    • Agarwal-Mawal, A., and Paudel, H.K. (2001). Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. J Biol Chem 276, 23712-23718.
    • (2001) J Biol Chem , vol.276 , pp. 23712-23718
    • Agarwal-Mawal, A.1    Paudel, H.K.2
  • 4
    • 33749164973 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory
    • Angelo, M., Plattner, F., and Giese, K.P. (2006). Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. J Neurochem 99, 353-370.
    • (2006) J Neurochem , vol.99 , pp. 353-370
    • Angelo, M.1    Plattner, F.2    Giese, K.P.3
  • 5
    • 1642289188 scopus 로고    scopus 로고
    • Role of tau protein in both physiological and pathological conditions
    • Avila, J., Lucas, J.J., Perez, M., and Hernandez, F. (2004). Role of tau protein in both physiological and pathological conditions. Physiol Rev 84, 361-384.
    • (2004) Physiol Rev , vol.84 , pp. 361-384
    • Avila, J.1    Lucas, J.J.2    Perez, M.3    Hernandez, F.4
  • 6
    • 0034680902 scopus 로고    scopus 로고
    • Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain
    • Bennecib, M., Gong, C.X., Grundke-Iqbal, I., and Iqbal, K. (2000). Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett 485, 87-93.
    • (2000) FEBS Lett , vol.485 , pp. 87-93
    • Bennecib, M.1    Gong, C.X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 8
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla, U.S., and Iyengar, R. (1999). Emergent properties of networks of biological signaling pathways. Science 283, 381-387.
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 10
    • 34548496016 scopus 로고    scopus 로고
    • The roles of cyclin-dependent kinase 5 in dendrite and synapse development
    • Cheung, Z.H., and Ip, N.Y. (2007). The roles of cyclin-dependent kinase 5 in dendrite and synapse development. Biotechnol J.
    • (2007) Biotechnol J
    • Cheung, Z.H.1    Ip, N.Y.2
  • 11
    • 27144478006 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
    • Cicero, S., and Herrup, K. (2005). Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J Neurosci 25, 9658-9668.
    • (2005) J Neurosci , vol.25 , pp. 9658-9668
    • Cicero, S.1    Herrup, K.2
  • 12
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D.A., Alessi, D.R., Cohen, P., Andjelkovich, M., and Hemmings, B.A. (1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 13
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • Cruz, J.C., Tseng, H.C., Goldman, J.A., Shih, H., and Tsai, L.H. (2003). Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40, 471-483.
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.C.2    Goldman, J.A.3    Shih, H.4    Tsai, L.H.5
  • 14
    • 0035067021 scopus 로고    scopus 로고
    • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    • Dawson, H.N., Ferreira, A., Eyster, M.V., Ghoshal, N., Binder, L.I., and Vitek, M.P. (2001). Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci 114, 1179-1187.
    • (2001) J Cell Sci , vol.114 , pp. 1179-1187
    • Dawson, H.N.1    Ferreira, A.2    Eyster, M.V.3    Ghoshal, N.4    Binder, L.I.5    Vitek, M.P.6
  • 17
    • 0141960033 scopus 로고    scopus 로고
    • beta-Amyloid induces paired helical filament-like tau filaments in tissue culture
    • Ferrari, A., Hoerndli, F., Baechi, T., Nitsch, R.M., and Gotz, J. (2003). beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. J Biol Chem 278, 40162-40168.
    • (2003) J Biol Chem , vol.278 , pp. 40162-40168
    • Ferrari, A.1    Hoerndli, F.2    Baechi, T.3    Nitsch, R.M.4    Gotz, J.5
  • 18
    • 27244435217 scopus 로고    scopus 로고
    • Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice
    • Fu, A.K., Ip, F.C., Fu, W.Y., Cheung, J., Wang, J.H., Yung, W.H., and Ip, N.Y. (2005). Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A 102, 15224-15229.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15224-15229
    • Fu, A.K.1    Ip, F.C.2    Fu, W.Y.3    Cheung, J.4    Wang, J.H.5    Yung, W.H.6    Ip, N.Y.7
  • 20
    • 18544390506 scopus 로고    scopus 로고
    • Post-translational modifications of tau protein in Alzheimer's disease
    • Gong, C.X., Liu, F., Grundke-Iqbal, I., and Iqbal, K. (2005). Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm 112, 813-838.
    • (2005) J Neural Transm , vol.112 , pp. 813-838
    • Gong, C.X.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 21
    • 0035800219 scopus 로고    scopus 로고
    • Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice
    • Gotz, J., and Nitsch, R.M. (2001). Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. Neuroreport 12, 2007-2016.
    • (2001) Neuroreport , vol.12 , pp. 2007-2016
    • Gotz, J.1    Nitsch, R.M.2
  • 22
    • 4744370969 scopus 로고    scopus 로고
    • Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models
    • Gotz, J., Schild, A., Hoerndli, F., and Pennanen, L. (2004). Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models. Int J Dev Neurosci 22, 453-465.
    • (2004) Int J Dev Neurosci , vol.22 , pp. 453-465
    • Gotz, J.1    Schild, A.2    Hoerndli, F.3    Pennanen, L.4
  • 23
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • Grundke-Iqbal, I., Iqbal, K., Tung, Y.C., Quinlan, M., Wisniewski, H.M., and Binder, L.I. (1986). Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83, 4913-4917.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4    Wisniewski, H.M.5    Binder, L.I.6
  • 26
    • 53949094601 scopus 로고    scopus 로고
    • Tau as a molecular marker of development, aging and neurodegenerative disorders
    • Hernandez, F., Perez, M., De Barreda, E.G., Goni-Oliver, P., and Avila, J. (2008). Tau as a molecular marker of development, aging and neurodegenerative disorders. Curr Aging Sci 1, 56-61.
    • (2008) Curr Aging Sci , vol.1 , pp. 56-61
    • Hernandez, F.1    Perez, M.2    De Barreda, E.G.3    Goni-Oliver, P.4    Avila, J.5
  • 27
    • 0034704958 scopus 로고    scopus 로고
    • Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor
    • Huang, K.X., and Paudel, H.K. (2000). Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor. Proc Natl Acad Sci U S A 97, 5824-5829.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5824-5829
    • Huang, K.X.1    Paudel, H.K.2
  • 28
    • 1842510004 scopus 로고    scopus 로고
    • Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    • Ingelsson, M. (2004). Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62, 925-931.
    • (2004) Neurology , vol.62 , pp. 925-931
    • Ingelsson, M.1
  • 31
    • 14244253319 scopus 로고    scopus 로고
    • Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies
    • Iqbal, K., and Grundke-Iqbal, I. (2005). Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathol (Berl) 109, 25-31.
    • (2005) Acta Neuropathol (Berl) , vol.109 , pp. 25-31
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 33
    • 33750510024 scopus 로고    scopus 로고
    • Alzheimer 100 - highlights in the history of Alzheimer research
    • Jellinger, K.A. (2006). Alzheimer 100 - highlights in the history of Alzheimer research. J Neural Transm 113, 1603-1623.
    • (2006) J Neural Transm , vol.113 , pp. 1603-1623
    • Jellinger, K.A.1
  • 34
    • 78049344162 scopus 로고    scopus 로고
    • Monte carlo simulations of tau proteins: effect of phosphorylation
    • Jho, Y.S., Zhulina, E.B., Kim, M.W., and Pincus, P.A. (2010). Monte carlo simulations of tau proteins: effect of phosphorylation. Biophys J 99, 2387-2397.
    • (2010) Biophys J , vol.99 , pp. 2387-2397
    • Jho, Y.S.1    Zhulina, E.B.2    Kim, M.W.3    Pincus, P.A.4
  • 35
    • 12344323961 scopus 로고    scopus 로고
    • Tau phosphorylation in neuronal cell function and dysfunction
    • Johnson, G.V., and Stoothoff, W.H. (2004). Tau phosphorylation in neuronal cell function and dysfunction. J Cell Sci 117, 5721-5729.
    • (2004) J Cell Sci , vol.117 , pp. 5721-5729
    • Johnson, G.V.1    Stoothoff, W.H.2
  • 36
    • 30344457896 scopus 로고    scopus 로고
    • Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
    • Kawauchi, T., Chihama, K., Nabeshima, Y., and Hoshino, M. (2006). Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol 8, 17-26.
    • (2006) Nat Cell Biol , vol.8 , pp. 17-26
    • Kawauchi, T.1    Chihama, K.2    Nabeshima, Y.3    Hoshino, M.4
  • 37
    • 0036434290 scopus 로고    scopus 로고
    • Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not inducetau hyperphosphorylation
    • Kerokoski, P., Suuronen, T., Salminen, A., Soininen, H., and Pirttila, T. (2002). Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not inducetau hyperphosphorylation. Biochem Biophys Res Commun 298, 693-698.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 693-698
    • Kerokoski, P.1    Suuronen, T.2    Salminen, A.3    Soininen, H.4    Pirttila, T.5
  • 38
    • 4444244237 scopus 로고    scopus 로고
    • Both Nmethyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamateinduced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons
    • Kerokoski, P., Suuronen, T., Salminen, A., Soininen, H., and Pirttila, T. (2004). Both Nmethyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamateinduced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons. Neurosci Lett 368, 181-185.
    • (2004) Neurosci Lett , vol.368 , pp. 181-185
    • Kerokoski, P.1    Suuronen, T.2    Salminen, A.3    Soininen, H.4    Pirttila, T.5
  • 41
    • 0035448915 scopus 로고    scopus 로고
    • p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment
    • Ko, J., Humbert, S., Bronson, R.T., Takahashi, S., Kulkarni, A.B., Li, E., and Tsai, L.H. (2001). p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21, 6758-6771.
    • (2001) J Neurosci , vol.21 , pp. 6758-6771
    • Ko, J.1    Humbert, S.2    Bronson, R.T.3    Takahashi, S.4    Kulkarni, A.B.5    Li, E.6    Tsai, L.H.7
  • 42
    • 0023434104 scopus 로고
    • MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum
    • Kosik, K.S., and Finch, E.A. (1987). MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum. J Neurosci 7, 3142-3153.
    • (1987) J Neurosci , vol.7 , pp. 3142-3153
    • Kosik, K.S.1    Finch, E.A.2
  • 43
    • 77955570062 scopus 로고    scopus 로고
    • Glutamate receptors neurotoxicity and neurodegeneration
    • Lau, A., and Tymianski, M. (2010). Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460, 525-542.
    • (2010) Pflugers Arch , vol.460 , pp. 525-542
    • Lau, A.1    Tymianski, M.2
  • 44
    • 0031127495 scopus 로고    scopus 로고
    • Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation
    • Lesort, M., Blanchard, C., Yardin, C., Esclaire, F., and Hugon, J. (1997). Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation. Brain Res Mol Brain Res 45, 127-132.
    • (1997) Brain Res Mol Brain Res , vol.45 , pp. 127-132
    • Lesort, M.1    Blanchard, C.2    Yardin, C.3    Esclaire, F.4    Hugon, J.5
  • 45
    • 0042817922 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is involved in neuregulindependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    • Li, B.S., Ma, W., Jaffe, H., Zheng, Y., Takahashi, S., Zhang, L., Kulkarni, A.B., and Pant, H.C. (2003). Cyclin-dependent kinase-5 is involved in neuregulindependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278, 35702-35709.
    • (2003) J Biol Chem , vol.278 , pp. 35702-35709
    • Li, B.S.1    Ma, W.2    Jaffe, H.3    Zheng, Y.4    Takahashi, S.5    Zhang, L.6    Kulkarni, A.B.7    Pant, H.C.8
  • 46
    • 1642345964 scopus 로고    scopus 로고
    • Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1
    • Li, Q., and Sudhof, T.C. (2004). Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem 279, 10542-10550.
    • (2004) J Biol Chem , vol.279 , pp. 10542-10550
    • Li, Q.1    Sudhof, T.C.2
  • 47
    • 33644849088 scopus 로고    scopus 로고
    • Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
    • Li, T., Hawkes, C., Qureshi, H.Y., Kar, S., and Paudel, H.K. (2006). Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta. Biochemistry 45, 3134-3145.
    • (2006) Biochemistry , vol.45 , pp. 3134-3145
    • Li, T.1    Hawkes, C.2    Qureshi, H.Y.3    Kar, S.4    Paudel, H.K.5
  • 49
    • 27644478606 scopus 로고    scopus 로고
    • Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    • Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C.X. (2005). Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
    • (2005) Eur J Neurosci , vol.22 , pp. 1942-1950
    • Liu, F.1    Grundke-Iqbal, I.2    Iqbal, K.3    Gong, C.X.4
  • 51
    • 33847239940 scopus 로고    scopus 로고
    • Structural principles of tau and the paired helical filaments of Alzheimer's disease
    • Mandelkow, E., Von Bergen, M., Biernat, J., and Mandelkow, E.M. (2007). Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathol 17, 83-90.
    • (2007) Brain Pathol , vol.17 , pp. 83-90
    • Mandelkow, E.1    Von Bergen, M.2    Biernat, J.3    Mandelkow, E.M.4
  • 53
    • 0029835019 scopus 로고    scopus 로고
    • A spatial gradient of tau protein phosphorylation in nascent axons
    • Mandell, J.W., and Banker, G.A. (1996). A spatial gradient of tau protein phosphorylation in nascent axons. J Neurosci 16, 5727-5740.
    • (1996) J Neurosci , vol.16 , pp. 5727-5740
    • Mandell, J.W.1    Banker, G.A.2
  • 54
    • 0036122349 scopus 로고    scopus 로고
    • Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A
    • Mora, A., Sabio, G., Risco, A.M., Cuenda, A., Alonso, J.C., Soler, G., and Centeno, F. (2002). Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. Cell Signal 14, 557-562.
    • (2002) Cell Signal , vol.14 , pp. 557-562
    • Mora, A.1    Sabio, G.2    Risco, A.M.3    Cuenda, A.4    Alonso, J.C.5    Soler, G.6    Centeno, F.7
  • 56
    • 0345432759 scopus 로고
    • Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro
    • Murphy, D.B., and Borisy, G.G. (1975). Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro. Proc Natl Acad Sci U S A 72, 2696-2700.
    • (1975) Proc Natl Acad Sci U S A , vol.72 , pp. 2696-2700
    • Murphy, D.B.1    Borisy, G.G.2
  • 57
    • 77649195559 scopus 로고    scopus 로고
    • A kinetic model of dopamineand calcium-dependent striatal synaptic plasticity
    • Nakano, T., Doi, T., Yoshimoto, J., and Doya, K. (2010). A kinetic model of dopamineand calcium-dependent striatal synaptic plasticity. PLoS Comput Biol 6, e1000670.
    • (2010) PLoS Comput Biol , vol.6
    • Nakano, T.1    Doi, T.2    Yoshimoto, J.3    Doya, K.4
  • 59
  • 60
    • 0029966469 scopus 로고    scopus 로고
    • The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
    • Nikolic, M., Dudek, H., Kwon, Y.T., Ramos, Y.F., and Tsai, L.H. (1996). The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev 10, 816-825.
    • (1996) Genes Dev , vol.10 , pp. 816-825
    • Nikolic, M.1    Dudek, H.2    Kwon, Y.T.3    Ramos, Y.F.4    Tsai, L.H.5
  • 63
    • 0032159462 scopus 로고    scopus 로고
    • Physiologic importance of protein phosphatase inhibitors
    • Oliver, C.J., and Shenolikar, S. (1998). Physiologic importance of protein phosphatase inhibitors. Front Biosci 3, D961-972.
    • (1998) Front Biosci , vol.3
    • Oliver, C.J.1    Shenolikar, S.2
  • 65
    • 45349086187 scopus 로고    scopus 로고
    • Systems biology in the study of neurological disorders: focus on alzheimer's disease
    • Pasinetti, G.M., and Hiller, S. (2008). SYSTEMS BIOLOGY IN THE STUDY OF NEUROLOGICAL DISORDERS: FOCUS ON ALZHEIMER'S DISEASE. Alcohol Research and Health 31, 60-65.
    • (2008) Alcohol Research and Health , vol.31 , pp. 60-65
    • Pasinetti, G.M.1    Hiller, S.2
  • 66
    • 84906282814 scopus 로고    scopus 로고
    • p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway
    • Patrick, G.N., Zhou, P., Kwon, Y.T., Howley, P.M., and Tsai, L.-H. (1998). p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway.
    • (1998)
    • Patrick, G.N.1    Zhou, P.2    Kwon, Y.T.3    Howley, P.M.4    Tsai, L.-H.5
  • 67
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • Patrick, G.N., Zukerberg, L., Nikolic, M., Monte, S.D.L., Dikkes, P., and Tsai, L.-H. (1999). Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402, 615-622.
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    Monte, S.D.L.4    Dikkes, P.5    Tsai, L.-H.6
  • 68
    • 77649250664 scopus 로고    scopus 로고
    • No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro
    • Peterson, D.W., Ando, D.M., Taketa, D.A., Zhou, H., Dahlquist, F.W., and Lew, J. (2010). No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc Natl Acad Sci U S A 107, 2884-2889.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2884-2889
    • Peterson, D.W.1    Ando, D.M.2    Taketa, D.A.3    Zhou, H.4    Dahlquist, F.W.5    Lew, J.6
  • 70
    • 33748752882 scopus 로고    scopus 로고
    • The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    • Plattner, F., Angelo, M., and Giese, K.P. (2006). The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem 281,25457-25465.
    • (2006) J Biol Chem , vol.281 , pp. 25457-25465
    • Plattner, F.1    Angelo, M.2    Giese, K.P.3
  • 71
    • 77951170019 scopus 로고    scopus 로고
    • The internal state of medium spiny neurons varies in response to different input signals
    • Qi, Z., Miller, G.W., and Voit, E.O. (2010). The internal state of medium spiny neurons varies in response to different input signals. BMC Syst Biol 4, 26
    • (2010) BMC Syst Biol , vol.4 , pp. 26
    • Qi, Z.1    Miller, G.W.2    Voit, E.O.3
  • 73
    • 0035966018 scopus 로고    scopus 로고
    • Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology.
    • Rashid, T., Banerjee, M., and Nikolic, M. (2001). Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. J Biol Chem 276, 49043-49052.
    • (2001) J Biol Chem , vol.276 , pp. 49043-49052
    • Rashid, T.1    Banerjee, M.2    Nikolic, M.3
  • 74
    • 0036154215 scopus 로고    scopus 로고
    • Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
    • Resjo, S., Goransson, O., Harndahl, L., Zolnierowicz, S., Manganiello, V., and Degerman, E. (2002). Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal 14, 231-238.
    • (2002) Cell Signal , vol.14 , pp. 231-238
    • Resjo, S.1    Goransson, O.2    Harndahl, L.3    Zolnierowicz, S.4    Manganiello, V.5    Degerman, E.6
  • 75
    • 0034067992 scopus 로고    scopus 로고
    • Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta
    • Reynolds, C.H., Betts, J.C., Blackstock, W.P., Nebreda, A.R., and Anderton, B.H. (2000). Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta. J Neurochem 74, 1587-1595.
    • (2000) J Neurochem , vol.74 , pp. 1587-1595
    • Reynolds, C.H.1    Betts, J.C.2    Blackstock, W.P.3    Nebreda, A.R.4    Anderton, B.H.5
  • 76
    • 33750014263 scopus 로고    scopus 로고
    • Extraneuronal roles of cyclin-dependent kinase 5
    • Rosales, J.L., and Lee, K.Y. (2006). Extraneuronal roles of cyclin-dependent kinase 5. Bioessays 28, 1023-1034.
    • (2006) Bioessays , vol.28 , pp. 1023-1034
    • Rosales, J.L.1    Lee, K.Y.2
  • 77
    • 33750072653 scopus 로고    scopus 로고
    • Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level
    • Sengupta, A., Novak, M., Grundke-Iqbal, I., and Iqbal, K. (2006). Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. FEBS Lett 580, 5925-5933.
    • (2006) FEBS Lett , vol.580 , pp. 5925-5933
    • Sengupta, A.1    Novak, M.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 78
    • 0030822508 scopus 로고    scopus 로고
    • Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex
    • Tashiro, K., Hasegawa, M., Ihara, Y., and Iwatsubo, T. (1997). Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport 8, 2797-2801.
    • (1997) Neuroreport , vol.8 , pp. 2797-2801
    • Tashiro, K.1    Hasegawa, M.2    Ihara, Y.3    Iwatsubo, T.4
  • 79
    • 0028820411 scopus 로고
    • Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules
    • Trinczek, B., Biernat, J., Baumann, K., Mandelkow, E.M., and Mandelkow, E. (1995). Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell 6, 1887-1902.
    • (1995) Mol Biol Cell , vol.6 , pp. 1887-1902
    • Trinczek, B.1    Biernat, J.2    Baumann, K.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 80
    • 84906253571 scopus 로고    scopus 로고
    • V.D.Rotterdam. Available [Accessed 2012]
    • V, D. (2009). Centre fot Medical System Biology [Online]. Rotterdam. Available: http://www.cmsb.nl/research/central_nervous_system_domain/alzheimers_disease.php [Accessed 2012]
    • (2009) Centre fot Medical System Biology [Online]
  • 81
    • 33846212717 scopus 로고    scopus 로고
    • Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
    • Wang, J.Z., Grundke-Iqbal, I., and Iqbal, K. (2007). Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur J Neurosci 25, 59-68.
    • (2007) Eur J Neurosci , vol.25 , pp. 59-68
    • Wang, J.Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 83
    • 40449087334 scopus 로고    scopus 로고
    • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    • Wen, Y., Planel, E., Herman, M., Figueroa, H.Y., Wang, L., Liu, L., Lau, L.F., Yu, W.H., and Duff, K.E. (2008). Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-2632.
    • (2008) J Neurosci , vol.28 , pp. 2624-2632
    • Wen, Y.1    Planel, E.2    Herman, M.3    Figueroa, H.Y.4    Wang, L.5    Liu, L.6    Lau, L.F.7    Yu, W.H.8    Duff, K.E.9
  • 86
    • 84902623629 scopus 로고    scopus 로고
    • Systems Biology
    • ed. Elsevier. 2 ed: Modelling Methodology for Physiology and Medicine (Second Edition))
    • Yang, R.F., Maria. Dolile Iii, Peter (2014). "Systems Biology," in Modelling Methodology for Physiology and Medicine, ed. Elsevier. 2 ed: Modelling Methodology for Physiology and Medicine (Second Edition)), 159-187.
    • (2014) Modelling Methodology for Physiology and Medicine , pp. 159-187
    • Yang, R.F.1    Maria Iii, D.2    Peter3
  • 87
    • 61349097283 scopus 로고    scopus 로고
    • Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases
    • Yu, Y., Run, X., Liang, Z., Li, Y., Liu, F., Liu, Y., Iqbal, K., Grundke-Iqbal, I., andGong, C.X. (2009). Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. J Neurochem 108, 1480-1494.
    • (2009) J Neurochem , vol.108 , pp. 1480-1494
    • Yu, Y.1    Run, X.2    Liang, Z.3    Li, Y.4    Liu, F.5    Liu, Y.6    Iqbal, K.7    Grundke-Iqbal, I.8    Gong, C.X.9
  • 88
    • 0031955853 scopus 로고    scopus 로고
    • Region-specific expression of cyclindependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system
    • Zheng, M., Leung, C.L., and Liem, R.K. (1998). Region-specific expression of cyclindependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J Neurobiol 35, 141-159.
    • (1998) J Neurobiol , vol.35 , pp. 141-159
    • Zheng, M.1    Leung, C.L.2    Liem, R.K.3
  • 90
    • 0036379174 scopus 로고    scopus 로고
    • A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
    • Zheng, Y.L., Li, B.S., Amin, N.D., Albers, W., and Pant, H.C. (2002). A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells. Eur J Biochem 269, 4427-4434.
    • (2002) Eur J Biochem , vol.269 , pp. 4427-4434
    • Zheng, Y.L.1    Li, B.S.2    Amin, N.D.3    Albers, W.4    Pant, H.C.5
  • 91
    • 33846828462 scopus 로고    scopus 로고
    • Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival
    • Zheng, Y.L., Li, B.S., Kanungo, J., Kesavapany, S., Amin, N., Grant, P., and Pant, H.C. (2007). Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival. Mol Biol Cell 18, 404-413.
    • (2007) Mol Biol Cell , vol.18 , pp. 404-413
    • Zheng, Y.L.1    Li, B.S.2    Kanungo, J.3    Kesavapany, S.4    Amin, N.5    Grant, P.6    Pant, H.C.7


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