Systems biology in the study of neurological disorders: Focus on Alzheimer's disease

Alcohol Research and Health

Volumn 31, Issue 1, 2008, Pages 60-65

  Pasinetti, Giulio M ^a,b   Hiller Sturmhöfel, Susanne ^c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c NONE

Author keywords

Alcohol and other drug effects (AODEs); Alzheimer's disease (AD); Biomarkers; Cognitive impairment; Complementary DNA (cDNA) microarray analysis; Dementia; Genetic risk factors; Protein array analysis; Proteomics; Systems biology

Indexed keywords

ALZHEIMER DISEASE; ANIMAL; DNA MICROARRAY; GENETICS; HUMAN; NERVOUS SYSTEM DISEASES; PATHOPHYSIOLOGY; PROCEDURES; SYSTEMS BIOLOGY;

ALZHEIMER DISEASE; ANIMALS; HUMANS; NERVOUS SYSTEM DISEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SYSTEMS BIOLOGY;

EID: 45349086187     PISSN: 15357414     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Alzheimer's Association. Fact Sheet: Alzheimer's Disease. Chicago, IL: Alzheimer's Association, 2006.
2. AUSTEN, B.M.; FREARS, E.R.; AND DAVIES, H. The use of Seldi ProteinChip™ Arrays to monitor production of Alzheimer's beta-amyloid in transfected cells. Journal of Peptide Science 6:459-469, 2000. PMID: 11016883
3. BEHER, D.; WRIGLEY, J.D.; OWENS, A.P.; AND SHEARMAN, M.S. Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity. Journal of Neurochemistry 82:563-575, 2002. PMID: 12153480
4. CARRETTE, O.; DEMALTE, I.; SCHERL, A.; ET AL. A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease. Proteomics 3:1486-1494, 2003. PMID: 12923774
5. DAVIES, H.; LOMAS, L.; AND AUSTEN, B. Profiling of amyloid beta peptide variants using SELDI Protein Chip arrays. Biotechniques 27:1258-1261, 1999. PMID: 10631507
6. FREARS, E.R.; STEPHENS, D.J.; WALTERS, C.H.; ET AL. The role of cholesterol in the biosynthesis of beta-amyloid. NeuroReport 10:1699-1705, 1999. PMID: 10501560
7. GOLDSTEIN, L.E.; MUFFAT, J.A.; CHERNY, R.A.; ET AL. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet 361:1258-1265, 2003. PMID: 12699953
8. HO, L.; GUO, Y.; SPIELMAN, L.; ET AL. Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique. Neuroscience Letters 298(3):191-194, 2001. PMID: 11165439
9. HO, L.; GINESTE, C.; AND POMPL, P.N. "Expression of Psoriasin and Xystain C in the CSF of Early Alzheimer's Disease." Originally presented in abstract form at the 2nd Annual Meeting of the Society of Neuroscience, Orlando, FL, 2002.
10. HO, L.; SHARMA, N.; BLACKMAN, L.; ET AL. From proteomics to biomarker discovery in Alzheimer's disease. Brain Research. Brain Research Reviews 48: 360-369, 2005.
11. KUKULL, W.A.; SCHELLENBERG, G.D.; BOWEN, J.D.; ET AL. Apolipoprotein E in Alzheimer's disease risk and case detection: A case-control study. Journal of Clinical Epidemiology 49(10):1143-1148, 1996. PMID: 8826994
12. LORING, J.F.; WEN, X.; LEE, J.M.; ET AL. A gene expression profile of Alzheimer's disease. DNA and Cell Biology 20(11):683-695, 2001.
13. MARCOTTE, E.R.; SRIVASTAVA, L.K.; AND QUIRION, R. cDNA microarray and proteomic approaches in the study of brain diseases: Focus on schizophrenia and Alzheimer's disease. Pharmacology and Therapeutics 100(1):63-74, 2003. PMID: 14550505
14. SHOJI, M. Cerebrospinal fluid Abeta40 and Abeta42: Natural course and clinical usefulness. Frontiers in Bioscience 7:d997-d1006, 2002. PMID: 11897565
15. TYAS, S.L. Alcohol use and the risk of developing Alzheimer's disease. Alcohol Research & Health 25(4):299-306, 2001. PMID: 11910708
16. VEHMAS, A.K.; BORCHELT, D.R.; PRICE, D.L.; ET AL. Beta-amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. DNA and Cell Biology 20:713-721, 2001. PMID: 11788049
17. WANG, J.; HO, L.; ZHAO, Z.; ET AL. Moderate consumption of Cabernet Sauvignon attenuates Abeta, neuropathology in a mouse model of Alzheimer's disease. FASEB Journal 20:2313-2320, 2006. PMID: 17077308
18. XIANG, Z.; HO, L.; YEMUL, S.; ET AL. Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expression 10:271-278, 2002. PMID: 12450219
19. YAO, P.J.; ZHU, M.; PYUN, E.I.; ET AL. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiology of Disease 12(2):97-109, 2003. PMID: 12667465