Cytoplasmic salt bridge formation in integrin αvß3 stabilizes its inactive state affecting integrin-mediated cell biological effects

Cellular Signalling

Volumn 26, Issue 11, 2014, Pages 2493-2503

  Müller, Martina A ^a   Brunie, Leonora ^a   Bächer, Anne Sophie ^a   Kessler, Horst ^a,b   Gottschalk, Kay Eberhard ^c   Reuning, Ute ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

Cytoplasmic salt bridge; Integrin activation; Integrin signaling; Integrin v 3; Ovarian cancer

Indexed keywords

FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PAXILLIN; PROTEIN KINASE B; TALIN; VITRONECTIN; VITRONECTIN RECEPTOR; CYTOSKELETON PROTEIN;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL ADHESION ASSAY; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASMIC SALT BRIDGE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTANT; OVARY CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; WILD TYPE; AMINO ACID SUBSTITUTION; CELL ADHESION; CHEMISTRY; GENETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR DYNAMICS; PHYSIOLOGY; PROTEIN STABILITY; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; CELL ADHESION; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; HUMANS; INTEGRIN ALPHAVBETA3; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STABILITY;

EID: 84906062910     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.07.013     Document Type: Article

References (57)

1. Humphries M.J. Biochem. Soc. Trans. 2000, 28:311-339.
2. Hynes R.O. Cell 2002, 110:673-687.
3. Shattil J.S., Kim C., Ginsberg M.H. Nat. Rev. Mol. Cell Biol. 2010, 11:288-300.
4. O'Toole T., Loftus J.C., Du X., Glas A.A., Ruggeri Z.M., Shattil S.J., Plow E.F., Ginsberg M.H. Cell. Regul. 1990, 1:883-893.
5. Sims P.J., Ginsberg M.H., Plow E.F., Shattil S.J. J. Biol. Chem. 1991, 266:7345-7352.
6. Adair B.D., Xiong J.P., Maddock C., Goodman S.L., Arnaout M.A., Yeager M. J. Cell Biol. 2005, 168:1109-1118.
7. Hughes P.E., Diaz-Gonzalez F., Leong L., Wu C., McDonald J.A., Shattil S.J., Ginsberg M.H. J. Biol. Chem. 1996, 271:6571-6574.
8. Kim M., Carman C.V., Springer T.A. Science 2003, 301:1720-1725.
9. Li W., Metcalf D.G., Gorelik R., Li R., Mitra N., Nanda V., Law P.B., Lear J.D., Degrado W.F., Bennett J.S. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:1424-1429.
10. Partridge A.W., Liu S., Kim S., Bowie J.U., Ginsberg M.H. J. Biol. Chem. 2005, 280:7294-7300.
11. Rocco M., Rosano C., Weisel J.W., Horita D.A., Hantgan R.R. Structure 2008, 16:954-964.
12. Zhu J., Carman C.V., Kim M., Shimaoka M., Springer T.A., Luo B.H. Blood 2007, 110:2475-2483.
13. Lau T.L., Kim C., Ginsberg M.H., Ulmer T.S. EMBO J. 2009, 28:1351-1361.
14. Takagi J., Petre B.M., Walz T., Springer T.A. Cell 2002, 110:599-611.
15. Vinogradova O., Velyvis A., Velyviene A., Hu B., Haas T., Plow E., Qin J. Cell 2002, 110:587-597.
16. Weljie A.M., Hwang P.M., Vogel H. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:5878-5883.
17. Ulmer T.S., Yaspan B., Ginsberg M.H., Campbell I.D. Biochemistry 2001, 40:7498-7508.
18. O'Toole T.E., Katagiri Y., Faull R.J., Peter K., Tamura R., Quaranta V., Shattil S.J., Ginsberg M.H. J. Cell Biol. 1994, 124:1047-1059.
19. Czuchra A., Meyer H., Legate K.R., Brakebusch C., Fässler R. J. Cell Biol. 2006, 174:889-899.
20. Imai Y., Park E.J., Peer D., Peixoto A., Cheng G., von Andrian U.H., Carman C.V., Shimaoka M. Blood 2008, 112:5007-5015.
21. Lössner D., Abou-Ajram C., Benge A., Reuning U. Int. J. Biochem. Cell Biol. 2008, 40:2746-2761.
22. Müller M.A., Opfer J., Brunie L., Volkhardt L.A., Sinner E.K., Boettiger D., Bochen A., Kessler H., Gottschalk K.E., Reuning U. J. Mol. Biol. 2013, 425:2988-3006.
23. Hapke S., Kessler H., Arroyo de Prada N., Benge A., Schmitt M., Lengyel E., Reuning U. J. Biol. Chem. 2001, 276:26340-26348.
24. Hapke S., Kessler H., Luber B., Benge A., Hutzler P., Höfler H., Schmitt M., Reuning U. Biol. Chem. 2003, 384:1073-1083.
25. Mas-Moruno C., Rechenmacher F., Kessler H. Anticancer Agents Med. Chem. 2010, 10:753-768.
26. Hu P., Luo B.H. J. Cell. Physiol. 2013, 228:306-312.
27. Yee K.L., Weaver V.M., Hammer D.A. IET Syst. Biol. 2008, 2:8-15.
28. Tadokoro S., Shattil S.J., Eto K., Tai V., Liddington R.C., de Pereda J.M., Ginsberg M.H., Calderwood D.A. Science 2003, 302:103-106.
29. Calderwood D.A., Zent R., Grant R., Rees D.J., Hynes R.O., Ginsberg M.H. J. Biol. Chem. 1999, 274:28071-28074.
30. Turner C.E. J. Cell Sci. 2000, 113:4139-4140.
31. Zhou X., Li J., Kucik D.F. J. Biol. Chem. 2001, 276:44762-44769.
32. Qin J., Vinogradova O., Plow E.F. PLoS Biol. 2004, 2:726-729.
33. Wegener K.L., Campbell I.D. Mol. Membr. Biol. 2008, 25:376-387.
34. Vinogradova O., Vaynberg J., Kong X., Haas T.A., Plow E.F., Qin J. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:4094-4099.
35. Kim C., Lau T.L., Ulmer T.S., Ginsberg M.H. Blood 2009, 113:4747-4753.
36. Lau T.L., Partridge A.W., Ginsberg M.H., Ulmer T.S. Biochemistry 2008, 47:4008-4016.
37. Lau T.L., Dua V., Ulmer T.S. J. Biol. Chem. 2008, 283:16162-16168.
38. Ma Y.Q., Yang J., Pesho M.M., Vinogradova O., Qin J., Plow E.F. Biochemistry 2006, 45:6656-6662.
39. Lössner D., Abou-Ajram C., Benge A., Aumercier M., Schmitt M., Reuning U. J. Cell. Physiol. 2009, 220:367-375.
40. Schaffner-Reckinger E., Salsmann A., Debili N., Bellis J., De Mey J., Vainchenker W., Ouwehand W.H., Kieffer N. J. Thromb. Haemost. 2009, 7:1207-1217.
41. Ghevaert C., Salsmann A., Watkins N.A., Schaffner-Reckinger E., Rankin A., Garner S.F., Stephens J., Smith G.A., Debili N., Vainchenker W., de Groot P.G., Huntington J.A., Laffan M., Kieffer N., Ouwehand W.H. Blood 2008, 111:3407-3414.
42. Lu C., Takagi J., Springer T.A. J. Biol. Chem. 2001, 276:14642-14648.
43. Wehrle-Haller B. Curr. Opin. Cell Biol. 2012, 24:569-581.
44. Howe A.K., Aplin A.E., Juliano R.L. Curr. Opin. Genet. Dev. 2002, 12:30-35.
45. Danen E.H., Yamada K.M. J. Cell. Physiol. 2001, 189:1-13.
46. Gottschalk K.E., Adams P.D., Brunger A.T., Kessler H. Protein Sci. 2002, 11:1800-1812.
47. Gottschalk K.E. Structure 2005, 13:703-712.
48. Liu S., Calderwood D.A., Ginsberg M.H. J. Cell Sci. 2000, 113:3563-3571.
49. Bouaouina M., Lad Y., Calderwood D.A. J. Biol. Chem. 2008, 283:6118-6125.
50. Lim J., Wiedemann A., Tzircotis G., Monkley S.J., Critchley D.R., Caron E. Mol. Biol. Cell 2007, 18:976-985.
51. Kalli A.C., Wegener K.L., Goult B.T., Anthis N.J., Campbell I.D., Sansom M.S. Structure 2010, 18:1280-1288.
52. Anthis N.J., Wegener K.L., Ye F., Kim C., Goult B.T., Lowe E.D., Vakonakis I., Bate N., Critchley D.R., Ginsberg M.H., Campbell I.D. EMBO J. 2009, 28:3623-3632.
53. Hughes P.E., O'Toole T.E., Ylanne Y., Shattil S.J., Ginsberg M.H. J. Biol. Chem. 1995, 270:12411-14217.
54. Kamata T., Irie A., Tokuhira M., Takada Y. J. Biol. Chem. 1996, 271:18610-18615.
55. Shattil S.J., Hoxie J.A., Cunningham M., Brass L.F. J. Biol. Chem. 1985, 260:11107-11114.
56. Tanaka-Takiguchi Y., Kakei T., Tanimura A., Takagi A., Honda M., Hotani H., Takiguchi K. J. Mol. Biol. 2004, 341:467-476.
57. Wolfenson H., Lavelin I., Geiger B. Dev. Cell 2013, 24:447-458.