Overexpression of the partially activated αIIb β3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells

Journal of Thrombosis and Haemostasis

Volumn 7, Issue 7, 2009, Pages 1207-1217

  Schaffner Reckinger, Elisabeth ^a   Salsmann, A ^a   Debili, N ^b   Bellis, J ^c   De Mey, J ^c   Vainchenker, W ^a   Ouwehand, W H ^d,e   Kieffer, N ^a,f  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NHS BLOOD AND TRANSPLANT   (United Kingdom)

^f SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B BETA 3 INTEGRIN; CD34 ANTIGEN; COMPLEMENTARY DNA; INTEGRIN; NOCODAZOLE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TALIN; UNCLASSIFIED DRUG; VINCULIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL ORGANELLE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CHINESE HAMSTER; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; GENE OVEREXPRESSION; HUMAN; IMMUNOFLUORESCENCE; MEGAKARYOCYTE; MICROSCOPY; MICROTUBULE ASSEMBLY; NERVE FIBER GROWTH; NONHUMAN; OVARY CELL; PHENOTYPE; PRIORITY JOURNAL; PSEUDOPODIUM; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA, COMPLEMENTARY; DOWN-REGULATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESIONS; MICROTUBULES; MUTATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RHOA GTP-BINDING PROTEIN;

EID: 67649496313     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2009.03494.x     Document Type: Article

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