Integrin αvβ3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 12, 2008, Pages 2746-2761

  Lössner, Daniela ^a   Abou Ajram, Claudia ^a   Benge, Anke ^a   Reuning, Ute ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Epidermal growth factor receptor; Epidermal growth factor receptor promoter; Integrin v 3; Ovarian cancer; Transcription factors

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; GROWTH FACTOR RECEPTOR; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P50; PROTEIN P53; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETF; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; RENILLA LUCIFERIN 2 MONOOXYGENASE; VITRONECTIN;

ARTICLE; CANCER CELL; CELL STIMULATION; DNA BINDING MOTIF; GENE EXPRESSION; HUMAN; HUMAN CELL; MUTATION; OVARY CANCER; PROTEIN INTERACTION; RECEPTOR UPREGULATION; REPRESSOR GENE; WILD TYPE; CELL PROLIFERATION; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; OVARY TUMOR; PATHOLOGY; REPORTER GENE; TUMOR CELL LINE; UPREGULATION;

CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAVBETA3; LUCIFERASES, RENILLA; OVARIAN NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFECTION; UP-REGULATION; VITRONECTIN;

EID: 51249114772     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.05.014     Document Type: Article

References (62)

1. Aaronson S.A. Growth factors and cancer. Science 254 (1991) 1146-1153
2. Adelsman M.A., McCarthy J.B., and Shimizu Y. Stimulation of β1-integrin function by epidermal growth factor and heregulin-β has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase. Mol Biol Cell 10 (1999) 2861-2878
3. Alper O., DeSantis M.L., Stromberg K., Hacker N.F., Cho-Chung Y.S., and Salomon D.S. Anti-sense suppression of epidermal growth factor receptor expression alters cellular proliferation, cell-adhesion, and tumorigenicity in ovarian cancer cells. Int J Cancer 88 (2000) 566-574
4. Assoian R.K., and Zhu X. Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr Opin Cell Biol 9 (1997) 93-98
5. Auersperg N., Wong A.S., Choi K.C., Kang S.K., and Leung P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocrinol Rev 22 (2001) 255-288
6. Barcellos-Hoff M.H., Park C., and Wright E.G. Radiation and the micro-environment-tumorigenesis and therapy. Nat Rev Cancer 5 (2005) 867-875
7. Brader K.R., Wolf J.K., Chakrabarty S., and Price J.E. Epidermal growth factor receptor (EGFR) antisense transfection reduces the expression of EGFR and suppresses the malignant phenotype of a human ovarian cancer cell line. Oncol Rep 5 (1998) 1269-1274
8. Burridge K., Fath K., Kelly T., Nuckolls G., and Turner C. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Ann Rev Cell Biol 4 (1988) 487-525
9. Cabodi S., Moro L., Bergatto E., Boeri Erba E., Di Stefano P., Turco E., et al. Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses. Biochem Soc Trans 32 (2004) 438-442
10. Cao H., Lei Z.M., Bian L., and Rao C.V. Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta. Endocrinology 136 (1995) 3163-3172
11. Carreiras F., Denoux Y., Staedel C., Lehmann M., Sichel F., and Gauduchon P. Expression and localization of alpha v integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma. Gynecol Oncol 62 (1996) 260-267
12. Carreiras F., Cruet S., Staedel C., Sichel F., and Gaudochon P. Human ovarian adenocarcinoma cells synthesize vitronectin and use it to organize their adhesion. Gynecol Oncol 72 (1999) 312-322
13. Chen P., Gupta K., and Wells A. Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J Cell Biol 124 (1994) 547-555
14. Chen P., Xie H., Sekar M.C., Gupta K., and Wells A. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J Cell Biol 127 (1994) 847-857
15. Chen Q., Kinch M.S., Lin T.H., Burridge K., and Juliano R.L. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 269 (1994) 26602-26605
16. Cruet S., Salamanca C., Mitchell G.W.E., and Auersperg N. αvβ3 and vitronectin expression by normal ovarian surface epithelial cells: role in cell adhesion and cell proliferation. Gynecol Oncol 75 (1999) 254-260
17. Deb S.P., Munoz R.M., Brown D.R., Subler M.A., and Deb S. Wild-type human p53 activates the human epidermal growth factor receptor promoter. Oncogene 9 (1994) 1341-1349
18. Felding-Haberman B. Integrin adhesion receptors in tumor metastasis. Clin Exp Metastasis 20 (2003) 203-213
19. Folgiero V., Bachelder R.E., Bon G., Sacchi A., Falcioni R., and Mercurio A.M. The α6β4 integrin can regulate ErbB-3 expression: implications for α6β4 signaling and function. Cancer Res 67 (2007) 1645-1652
20. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
21. Gilmore T., Gapuzan M.E., Kalaitzidis D., and Starczynowski D. Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer. Cancer Lett 181 (2002) 1-9
22. Haley J., Whittle N., Bennet P., Kinchington D., Ullrich A., and Waterfield M. The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription. Oncogene Res 1 (1987) 375-396
23. Hapke S., Gawaz M., Dehne K., Köhler J., Marshall J.F., Graeff H., et al. Beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter. Mol Cell Biol 21 (2001) 2118-2132
24. Hapke S., Kessler H., Arroyo de Prada N., Benge A., Schmitt M., Lengyel E., et al. Integrin αvβ3/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells. J Biol Chem 276 (2001) 26340-26348
25. Hapke S., Kessler H., Luber B., Benge A., Hutzler P., Höfler H., et al. Ovarian cancer cell proliferation and motility is induced by engagement of integrin αvβ3/vitronectin interaction. Biol Chem 384 (2003) 1073-1083
26. Hehlgans S., Haase M., and Cordes N. Signaling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775 (2007) 163-180
27. Hou X., Johnson A.C., and Rosner M.R. Identification of an epidermal growth factor receptor transcriptional repressor. J Biol Chem 269 (1994) 4307-4312
28. Jorissen R.N., Walker F., Pouliot N., Garrett T.P., Ward C.W., and Burgess A.W. Epidermal growth factor receptor: mechanisms of activation and signaling. Exp Cell Res 284 (2003) 31-53
29. Kageyama R., Merlino G.T., and Pastan I. Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor. J Biol Chem 263 (1988) 6329-6336
30. Klemke R.L., Yebra M., Bayna E.M., and Cheresh D.A. Receptor tyrosine kinase signaling required for integrin αvβ5-directed cell motility but not adhesion on vitronectin. J Cell Biol 127 (1994) 859-866
31. Leavesley D.I., Schwartz M.A., Rosenfeld M., and Cheresh D. Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J Cell Biol 12 (1993) 163-170
32. Li J., Lin M.L., Wiepz G.J., Guadarrama A.G., and Bertics P.J. Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor. J Biol Chem 274 (1999) 11209-11219
33. Liapis H., Adler L.M., Wick M.R., and Rader J.S. Expression of αvβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas. Human Pathol 28 (1997) 443-449
34. Lichter R.B., Wiedemuth M., Noeske-Jungblut C., and Schirrmacher V. Rapid effects of EGF on cytoskeletal structures and adhesive properties of highly metastatic rat mammary adenocarcinoma cells. Clin Exp Metastasis 11 (1993) 113-125
35. Maihle N.J., Baron A.T., Barrette B.A., Boardman C.H., Christensen T.A., Cora E.M., et al. EGF/ErbB receptor family in ovarian cancer. Cancer Treat Res 107 (2002) 247-258
36. Mattila E., Pellinen T., Nevo J., Vuoriluoto K., Arjonen A., and Ivaska J. Negative regulation of EGFR signaling through integrin α1β1-mediated activation of protein tyrosine phosphatase TCPTP. Nat Cell Biol 7 (2005) 78-85
37. Miller W.E., Cheshire J.L., Baldwin Jr. A.S., and Raab-Traub N. The NPC derived C15 LMP1 protein confers enhanced activation of NF-κB and induction of the EGF-R in epithelial cells. Oncogene 16 (1998) 1869-1877
38. Miyamoto S., Teramoto H., Gutkind J.S., and Yamada K.M. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 135 (1996) 1633-1642
39. Morino N., Mimura T., Hamasaki K., Tobe K., Ueki K., Kikuchi K., et al. Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J Biol Chem 270 (1995) 269-273
40. Moro L., Venturino M., Bozzo C., Silengo L., Altruda F., Beguinot L., et al. Integrins activate EGF-R: role in MAPK induction and adhesion-dependent cell survival. EMBO J 17 (1998) 6622-6632
41. Moro L., Dolce L., Cabodi S., Bergatto E., Boeri Erba E., Smeriglio M., et al. Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem 277 (2002) 9405-9414
42. Ning Y., Buranda T., and Hudson L.G. Activated epidermal growth factor receptor induces integrin alpha2 internalization via caveolae/raft-dependent endocytic pathway. J Biol Chem 282 (2007) 6380-6387
43. Nishi H., Neta G., Nishi K.H., Akers L.M., Rikiyama T., Proctor K.N., et al. Analysis of the epidermal growth factor receptor promoter: the effect of nuclear factor-kappa B. Int J Mol Med 11 (2003) 49-55
44. Ozols R.F., Bookman M.A., Connolly D.C., Daly M.B., Godwin A.K., Schilder R.J., et al. Focus on epithelial ovarian cancer. Cancer Cell 5 (2004) 19-24
45. Reuning U., Guerrini L., Nishiguchi T., Page S., Seibold H., Magdolen V., et al. Rel transcription factors contribute to elevated urokinase expression in human ovarian carcinoma cells. Eur J Biochem 259 (1999) 143-148
46. Riemenschneider M.J., Mueller W., Betensky R.A., Mohapatra G., and Louis D.N. In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. Am J Pathol 167 (2005) 1379-1387
47. Rosano L., Di Castro V., Spinella F., Tortora G., Nicotra M.R., Natali P.G., et al. Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity. Cancer Res 67 (2007) 6351-6359
48. Rusciano D., Lorenzoni P., and Burger M.M. Constitutive activation of c-Met in liver metastatic B16 melanoma cells depends on both substrate adhesion and cell density and is regulated by a cytosolic tyrosine phosphatase activity. J Biol Chem 271 (1996) 20763-20769
49. Schneller M., Vuori K., and Ruoslahti E. Integrin αvβ3 associates with activated insulin and PDGF-β receptors and potentiates the biological activity of PDGF. EMBO J 16 (1997) 5600-5607
50. Schwartz M.A., and Baron V. Interactions between mitogenic stimuli, or, a thousand and one connections. Curr Opin Cell Biol 11 (1999) 197-202
51. Sieg D.J., Hauck C.R., Ilic D., Klingbeil C.K., Schaefer E., Damsky C.H., et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2 (2000) 249-256
52. Soldi R., Mitola S., Strasly M., Defilippi P., Tarone G., and Bussolino F. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J 18 (1999) 882-892
53. Stadlmann S., Gueth U., Reiser U., Diener P.A., Zeimet A.G., Wight E., et al. Epithelial growth factor receptor status in primary and recurrent ovarian cancer. Modern Pathol 19 (2006) 607-610
54. Stromberg K., Collins IV T.J., Gordon A.W., Jackson C.L., and Johnson G.R. Transforming growth factor-α acts as an autocrine growth factor in ovarian carcinoma cell lines. Cancer Res 52 (1992) 341-347
55. Sundberg C., and Rubin K. Stimulation of β1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β-receptors. J Cell Biol 132 (1996) 741-752
56. Wang R., Kobayashi R., and Bishop J.M. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc Natl Acad Sci USA 93 (1996) 8425-8430
57. Woodard A.S., Garcia-Cardena G., Leong M., Madri J.A., Sessa W.C., and Languino L.R. The synergistic activity of αvβ3 integrin and PDGF receptor increases cell migration. J Cell Sci 111 (1998) 469-478
58. Xu Y.-H., Richert N., Ito S., Merlino G.T., and Pastan I. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proc Natl Acad Sci USA 81 (1984) 7308-7312
59. Yamada K.M., and Even-Ram S. Integrin regulation of growth factor receptors. Nat Cell Biol 4 (2002) E75-76
60. Yenush L., Kundra V., White M.F., and Zetter B.R. Functional domains of the insulin receptor responsible for chemotactic signaling. J Biol Chem 269 (1994) 100-104
61. Yoon S.O., Shin S., and Lipscomb E.A. A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the α6β4 integrin regulates erbB2 translation and transactivates epidermal growth factor receptor/erbB2 signaling. Cancer Res 66 (2006) 2732-2739
62. Zhu X., and Assoian R.K. Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 6 (1995) 273-282