Transcriptional regulation of endothelial dysfunction in atherosclerosis: An epigenetic perspective

Journal of Biomedical Research

Volumn 28, Issue 1, 2014, Pages 47-52

  Xu, Yong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Endothelial injury; Epigenetics; Transcriptional regulation

Indexed keywords

EID: 84906060975     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.7555/JBR.27.20130055     Document Type: Article

References (59)

1. Kita T, Ishii K, Yokode M, Kume N, Nagano Y, Arai H, et al. The role of oxidized low density lipoprotein in the pathogenesis of atherosclerosis. Eur Heart J 1990; 11 (Suppl) E:122-7.
2. Topper JN, Cai J, Falb D, Gimbrone MA, Jr. Identifica-tion of vascular endothelial genes differentially respon-sive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci U S A 1996; 93: 10417-22.
3. Libby P, Ridker PM, Hansson GK. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-38.
4. Davies PF. Endothelial transcriptome profiles in vivo in complex arterial flow fields. Ann Biomed Eng 2008; 36: 563-70.
5. Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Jr., Davies PF. Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis. Circ Cardiovasc Genet 2011; 4: 243-52.
6. McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Per-digoto AL, Brooks JD, et al. Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells. J Biol Chem 2005; 280: 22172-80.
7. Lee YW, Eum SY, Chen KC, Hennig B, Toborek M. Gene expression profile in interleukin-4-stimulated hu-man vascular endothelial cells. Mol Med 2004; 10: 19-27.
8. Di Camillo B, Sanavia T, Iori E, Bronte V, Roncaglia E, Maran A, et al. The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach. PLoS One 2010; 5: e14390.
9. Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells. Arterioscler Thromb Vasc Biol 2004; 24: 2088-94.
10. Barreiro O, Martin P, Gonzalez-Amaro R, Sanchez-Ma-drid F. Molecular cues guiding inflammatory responses. Cardiovasc Res 2010; 86: 174-82.
11. Lund G, Zaina S. Epigenetics, transgenerational effects and risk factors for atherosclerosis. Curr Opin Lipidol 2009; 20: 150-1.
12. Turunen MP, Aavik E, Yla-Herttuala S. Epigenetics and atherosclerosis. Biochimica et biophysica acta 2009; 1790: 886-91.
13. Bird A. Perceptions of epigenetics. Nature 2007; 447: 396-8.
14. Jenuwein T, Allis CD. Translating the histone code. Sci-ence 2001; 293: 1074-80.
15. Fischle W, Wang Y, Allis CD. Binary switches and mod-ification cassettes in histone biology and beyond. Nature 2003; 425: 475-9.
16. Saha A, Wittmeyer J, Cairns BR. Chromatin remodel-ling: the industrial revolution of DNA around histones. Nat Rev Mol Cell Biol 2006; 7: 437-47.
17. Peterson CL, Herskowitz I. Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 1992; 68: 573-83.
18. Stern M, Jensen R, Herskowitz I. Five SWI genes are required for expression of the HO gene in yeast. J Mol Biol 1984; 178: 853-68.
19. Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Nature 1993; 366: 170-4.
20. Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR. Diversity and specialization of mammalian SWI/ SNF complexes. Genes Dev 1996; 10: 2117-30.
21. He P. Leucocyte/endothelium interactions and microves-sel permeability: coupled or uncoupled? Cardiovasc Res 2010; 87: 281-90.
22. Schmidt AM, Yan SD, Wautier JL, Stern D. Activa-tion of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circulation research 1999; 84: 489-97.
23. El-Osta A, Brasacchio D, Yao D, Pocai A, Jones PL, Roeder RG, et al. Transient high glucose causes persist-ent epigenetic changes and altered gene expression dur-ing subsequent normoglycemia. The Journal of experi-mental medicine 2008; 205: 2409-17.
24. Chen H, Li D, Saldeen T, Mehta JL. Transforming growth factor-beta(1) modulates oxidatively modified LDL-induced expression of adhesion molecules: role of LOX-1. Circ Res 2001; 89: 1155-60.
25. Fang F, Yang Y, Yuan Z, Gao Y, Zhou J, Chen Q, et al. Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury. Circ Res 2011; 108: 797-807.
26. Lockman K, Taylor JM, Mack CP. The histone demeth-ylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression. Circ Res 2007; 101: e115-23.
27. Zhang M, Fang H, Zhou J, Herring BP. A novel role of Brg1 in the regulation of SRF/MRTFA-dependent smooth muscle-specific gene expression. J Biol Chem 2007; 282: 25708-16.
28. Zhou J, Zhang M, Fang H, El-Mounayri O, Rodenberg JM, Imbalzano AN, et al. The SWI/SNF chromatin re-modeling complex regulates myocardin-induced smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 2009; 29: 921-8.
29. Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, et al. Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined ac-tivities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem 2009; 284: 23125-36.
30. Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG. Butyrate modulates gene and protein expression in human intestinal endothelial cells. Bio-chem Biophys Res Commun 2003; 309: 512-9.
31. Chen KC, Liao YC, Hsieh IC, Wang YS, Hu CY, Juo SH. OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases. J Mol Cell Cardiol 2012; 52: 587-95.
32. Chen KC, Wang YS, Hu CY, Chang WC, Liao YC, Dai CY, et al. OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases. FASEB J 2011; 25: 1718-28.
33. Mitra S, Khaidakov M, Lu J, Ayyadevara S, Szwedo J, Wang XW, et al. Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation. American journal of physiology Heart and circulatory physiology 2011; 301: H506-13.
34. Drager LF, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: an emerging risk factor for atherosclerosis. Chest 2011; 140: 534-42.
35. Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 2006; 99: 675-91.
36. Oemar BS, Tschudi MR, Godoy N, Brovkovich V, Ma-linski T, Luscher TF. Reduced endothelial nitric oxide synthase expression and production in human athero-sclerosis. Circulation 1998; 97: 2494-8.
37. Teichert AM, Scott JA, Robb GB, Zhou YQ, Zhu SN, Lem M, et al. Endothelial nitric oxide synthase gene ex-pression during murine embryogenesis: commencement of expression in the embryo occurs with the establish-ment of a unidirectional circulatory system. Circ Res 2008; 103: 24-33.
38. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, et al. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP re-laxation pathway, and hypertension. American journal of physiology Heart and circulatory physiology 2011; 301: H1862-71.
39. Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Jr., Gavryushova A, et al. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with evic-tion of promoter histones. J Biol Chem 2010; 285: 810-26.
40. Kheirandish-Gozal L, Khalyfa A, Gozal D, Bhattachar-jee R, Wang Y. Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene. Chest 2013; 143: 971-7.
41. Xu XF, Gu WZ, Wu XL, Li RY, Du LZ. Fetal pulmo-nary vascular remodeling in a rat model induced by hy-poxia and indomethacin. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2011; 24: 172-82.
42. Xu XF, Ma XL, Shen Z, Wu XL, Cheng F, Du LZ. Epi-genetic regulation of the endothelial nitric oxide syn-thase gene in persistent pulmonary hypertension of the newborn rat. J Hypertens 2010; 28: 2227-35.
43. Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical per-spectives. Physiol Rev 2011; 91: 327-87.
44. Davies PF, Remuzzi A, Gordon EJ, Dewey CF, Jr., Gim-brone MA, Jr. Turbulent fluid shear stress induces vascu-lar endothelial cell turnover in vitro. Proc Natl Acad Sci U S A 1986; 83: 2114-7.
45. Freyberg MA, Kaiser D, Graf R, Buttenbender J, Friedl P. Proatherogenic flow conditions initiate endothelial ap-optosis via thrombospondin-1 and the integrin-associated protein. Biochem Biophys Res Commun 2001; 286: 141-9.
46. Kleindienst R, Xu Q, Willeit J, Waldenberger FR, Wei-mann S, Wick G. Immunology of atherosclerosis. Dem-onstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions. Am J Pathol 1993; 142: 1927-37.
47. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland SM, et al. Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. J Biol Chem 2003; 278: 47291-8.
48. Illi B, Nanni S, Scopece A, Farsetti A, Biglioli P, Ca-pogrossi MC, et al. Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. Circ Res 2003; 93: 155-61.
49. Lopez-Ongil S, Hernandez-Perera O, Navarro-Antolin J, Perez de Lema G, Rodriguez-Puyol M, Lamas S, et al. Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells. Br J Pharmacol 1998; 124: 447-54.
50. Boulanger CM, Tanner FC, Bea ML, Hahn AW, Werner A, Luscher TF. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ Res 1992; 70: 1191-7.
51. Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S. Cur-cumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition 2009; 25: 964-72.
52. Chen S, Feng B, George B, Chakrabarti R, Chen M, Chakrabarti S. Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. American journal of physiology Endocrinology and me-tabolism 2010; 298: E127-37.
53. Wort SJ, Ito M, Chou PC, Mc Master SK, Badiger R, Jazrawi E, et al. Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. J Biol Chem 2009; 284: 24297-305.
54. Xu XF, Lv Y, Gu WZ, Tang LL, Wei JK, Zhang LY, et al. Epigenetics of hypoxic pulmonary arterial hyperten-sion following intrauterine growth retardation rat: epi-genetics in PAH following IUGR. Respiratory research 2013; 14: 20.
55. Yang YY, Chen DW, Yuan ZB, Fang F, Cheng X, Xia J, et al. Megakaryocytic leukemia 1 (MKL1) ties the epi-genetic machinery to hypoxia induced transactivation of endothelin-1. Nucleic Acids Res 2013.
56. Marx V. Epigenetics: Reading the second genomic code. Nature 2012; 491: 143-7.
57. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 2010; 143: 156-69.
58. Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, et al. The histone methyltrans-ferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity 2012; 36: 572-85.
59. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 2010; 466: 508-12