Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression

Circulation Research

Volumn 93, Issue 2, 2003, Pages 155-161

  Illi, Barbara ^a   Nanni, Simona ^b   Scopece, Alessandro ^c   Farsetti, Antonella ^b,d   Biglioli, Paolo ^a   Capogrossi, Maurizio C ^c   Gaetano, Carlo ^c  

^a IRCC Foundation   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^d CNR   (Italy)

Author keywords

Chromatin; Endothelial cells; Gene expression; Histone acetylation; Histone phosphorylation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; HISTONE ACETYLTRANSFERASE; HISTONE H3; HISTONE H4; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE 1; S6 KINASE 2; SERINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; WORTMANNIN;

ACETYLATION; ARTICLE; BLOOD FLOW; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HEMODYNAMICS; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SHEAR STRESS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACETYLATION; ACETYLTRANSFERASES; CELLS, CULTURED; CHROMATIN; CREB-BINDING PROTEIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENES, JUN; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-FOS; RHEOLOGY; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, MECHANICAL; TRANS-ACTIVATORS; UMBILICAL VEINS;

EID: 0042266790     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000080933.82105.29     Document Type: Article

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