Gene expression profile in interleukin-4-stimulated human vascular endothelial cells

Molecular Medicine

Volumn 10, Issue 1-6, 2004, Pages 19-27

  Lee, Yong Woo ^a   Eum, Sung Yong ^a   Chen, Kuey Chu ^a   Hennig, Bernhard ^b   Toborek, Michal ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CELL ADHESION; CELL STIMULATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; METABOLIC REGULATION; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE; VASCULAR ENDOTHELIUM;

APOPTOSIS; CELL LINE, TUMOR; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-4; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 7444259052     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Ross R. (1999) Atherosclerosis is an inflammatory disease. Am. Heart. J. 138:S419-20.
2. Davies MJ et al. (1993) The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J. Pathol. 171:223-9.
3. Cotran RS, Mayadas-Norton T. (1998) Endothelial adhesion molecules in health and disease. Pathol. Biol. 46:164-70.
4. Reape TJ, Groot PH. (1999) Chemokines and atherosclerosis. Atherosclerosis 147:213-25.
5. Rus HG, Niculescu F, Vlaicu R. (1991) Tumor necrosis factor-alpha in human arterial wall with atherosclerosis. Atherosclerosis 89:247-54.
6. Paul WE. (1991) Interleukin-4: A prototypic immunoregulatory lymphokine. Blood 77:1859-70.
7. Rocken M, Racke M, Shevach EM. (1991) IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17:225-31.
8. Sasaguri T et al. (1998) A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells. Atherosclerosis 138:247-53.
9. Galea P, Chartier A, Lebranchu Y. (1991) Increased lymphocyte adhesion to allogeneic endothelial cells by interleukin-4 (IL-4). Transplant Proc. 23:243-44.
10. Lee YW, Kühn H, Hennig B, Neish AS, Toborek M. (2001) IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. J. Mol. Cell. Cardiol. 33:83-94.
11. Rollins BJ, Pober JS. (1991) Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells. Am. J. Pathol. 138:1315-9.
12. Lee YW, Hennig B, Toborek M. (2003) Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 284:H185-92.
13. Brinckmann R et al. (1996) Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4. Biochem. J. 318:305-12.
14. Lee YW et al. (2001) Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells. J. Lipid Res. 42:783-91.
15. Toborek M, Lee YW, Kaiser S, Hennig B. (2002) Measurement of inflammatory properties of fatty acids in human endothelial cells. Methods Enzymol. 352:198-219.
16. Blalock EM et al. (2003) Gene microarrays in hippocampal aging: Statistical profiling identifies novel processes correlated with cognitive impairment. J. Neurosci. 23:3807-19.
17. Blalock EM et al. (2004) Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. U.S.A. 101:2173-8.
18. CT method. Methods 25:402-8.
19. Deng X, Li H, Tang YW. (2003) Cytokine expression in respiratory syncytial virus-infected mice as measured by quantitative reverse-transcriptase PCR. J. Virol. Methods. 107:141-6.
20. Braut-Boucher F et al. (1995) A non-isotopic, highly sensitive, fluorimetric, cell-cell adhesion microplate assay using calcein AM-labeled lymphocytes. J. Immunol. Methods. 178:41-51.
21. Choi W et al. (2003) PCB 104-induced proinflammatory reactions in human vascular endothelial cells: Relationship to cancer metastasis and atherogenesis. Toxicol. Sci. 75:47-56.
22. Watson A, Mazumder A, Stewart M, Balasubramanian S. (1998) Technology for microarray analysis of gene expression. Curr. Opin. Biotechnol. 9:609-14.
23. Schulze A, Downward J. (2001) Navigating gene expression using microarrays-a technology review. Nature Cell Biol. 3:E190-5.
24. Golub TR et al. (1999) Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring. Science 286:531-7.
25. Hiltunen MO et al. (2002) Changes in gene expression in atherosclerotic plaques analyzed using DNA array. Atherosclerosis 165:23-32.
26. Bowler RP et al. (2002) A catalytic antioxicant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Radic. Biol. Med. 33:947-61.
27. Ginsberg SD, Hemby SE, Lee VM, Eberwine JH, Trojanowski JQ. (2000) Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48:77-87.
28. Geiss GK et al. (2000) Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology. 266:8-16.
29. Mimics K, Middleton FA, Marquez A, Lewis DA, Levitt P. (2000) Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron. 28:53-67.
30. Chen YW, Zhao P, Borup R, Hoffman EP. (2000) Expression profiling in the muscular dystrophies: Identification of novel aspects of molecular pathophysiology. J. Cell Biol. 151:1321-36.
31. Masinovsky B, Urdal D, Gallatin WM. (1990) IL-4 acts synergistically with IL-1β to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J. Immunol. 145:2886-95.
32. Blease K, Seybold J, Adcock IM, Hellewell PG, Burke-Gaffney A. (1998) Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells. Am. J. Respir. Cell Mol. Biol. 18:620-30.
33. Cybulsky M, Gimbrone M. (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251:788-91.
34. Whelan J. (1996) Selectin synthesis and inflammation. Trends Biochem. Sci. 21:65-9.
35. Bennett BL, Cruz R, Lacson RG, Manning AM. (1997) Interleukin-4 suppression of tumor necrosis factor α-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-κB. J. Biol. Chem. 272:10212-9.
36. Thornhill MH, Haskard DO. (1990) IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-γ. J. Immunol. 145:865-72.
37. Gu L, Tseng SC, Rollins BJ. (1999) Monocyte chemoattractant protein-1. Chem. Immunol. 72:7-29.
38. Rollins BJ. (1997) Chemokines. Blood 90:909-28.
39. Libby P, Ridker PM, Maseri A. (2002) Inflammation and atherosclerosis. Circulation 105:1135-43.
40. Chen CC, Manning AM. (1996) TGF-β1, IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells. Cytokine 8:58-65.