Obstructive sleep apnea: An emerging risk factor for atherosclerosis

Chest

Volumn 140, Issue 2, 2011, Pages 534-542

  Drager, Luciano F ^a   Polotsky, Vsevolod Y ^c   Lorenzi Filho, Geraldo ^b  

^a University of Saandtild   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CATECHOLAMINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; L SELECTIN; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN; PADGEM PROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VERY LOW DENSITY LIPOPROTEIN;

AROUSAL; ASPHYXIA; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; DEPRESSION; DIABETES MELLITUS; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; GENETIC PREDISPOSITION; HEART INFARCTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; HYPOXIA; IMMOBILIZATION; INSULIN RESISTANCE; LIPID PEROXIDATION; NONHUMAN; OBESITY; OCCLUSIVE CEREBROVASCULAR DISEASE; OXIDATIVE STRESS; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SLEEP APNEA SYNDROME; SMOKING; SNORING; STROKE;

EID: 80051479908     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-2223     Document Type: Review

References (89)

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230-1235. (Pubitemid 23115702)
2. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet.2005;365(9464):1046-1053. (Pubitemid 40386782)
3. Young T, Finn L, Peppard PE, et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008;31(8):1071-1078.
4. Marshall NS, Wong KK, Liu PY, Cullen SR, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008;31(8):1079-1085.
5. Punjabi NM, Caffo BS, Goodwin JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med.2009;6(8):e1000132.
6. Redline S, Yenokyan G, Gottlieb DJ, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182(2):269-277.
7. Libby P, Ridker PM, Hansson GK;Leducq Transatlantic Network on Atherothrombosis. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol.2009;54(23):2129-2138.
8. Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995;92(5):1355-1374.
9. Ridker PA, Libby P. Risk factors for atherothrombotic disease. In: Libby B, Mann Z, eds. Braunwald's Heart Disease. A Textbook of Cardiovascular Disease. 8th ed. Philadelphia, PA: Saunders Elservier; 2008:1003-1026.
10. Chobanian AV, Bakris GL, Black HR, et al Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension.2003;42(6):1206-1252. (Pubitemid 37553153)
11. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med. 2002;165(5):677-682. (Pubitemid 34194756)
12. Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med. 2009;122(12):1122-1127.
13. Jun J, Reinke C, Bedja D, et al. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis. 2010;209(2):381-386.
14. Savransky V, Nanayakkara A, Li J, et al. Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med.2007;175(12):1290-1297. (Pubitemid 46905755)
15. Savransky V, Bevans S, Nanayakkara A, et al. Chronic intermittent hypoxia causes hepatitis in a mouse model of dietinduced fatty liver. Am J Physiol Gastrointest Liver Physiol.2007;293(4):G871-G877. (Pubitemid 47605939)
16. Savransky V, Jun J, Li J, et al. Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ Res.2008;103(10):1173-1180.
17. Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP, Polotsky VY. Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol. 2007;102(2):557-563. (Pubitemid 46220883)
18. Li J, Thorne LN, Punjabi NM, et al. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res. 2005;97(7):698-706. (Pubitemid 41416339)
19. Drager LF, Li J, Shin MK, et al. Intermittent hypoxia inhibits clearance of triglyceride rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnea [published online ahead of print April 9, 2011]. Eur Heart J.doi: 10.1093 eurheartj/ehr097.
20. Merkel M, Eckel RH, Goldberg IJ. Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res. 2002;43(12):1997-2006. (Pubitemid 35471065)
21. Iesato K, Tatsumi K, Saibara T, et al. Decreased lipoprotein lipase in obstructive sleep apnea syndrome. Circ J. 2007;71(8):1293-1298. (Pubitemid 47195349)
22. Drager LF, Jun J, Polotsky VY. Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis [published correction appears in Curr Opin Endocrinol Diabetes Obes.2010;17(4):394]. Curr Opin Endocrinol Diabetes Obes. 2010;17(2):161-165.
23. Drager LF, Jun JC, Polotsky VY. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best Pract Res Clin Endocrinol Metab. 2010;24(5):843-851.
24. Stocker R, Keaney JF Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004;84(4):1381-1478. (Pubitemid 39302636)
25. Podrez EA, Poliakov E, Shen Z, et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem.2002;277(41):38503-38516. (Pubitemid 35154709)
26. Jun J, Savransky V, Nanayakkara A, et al. Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2008;295(4):R1274-R1281.
27. Lattimore JD, Wilcox I, Nakhla S, Langenfeld M, Jessup W, Celermajer DS. Repetitive hypoxia increases lipid loading in human macrophages-a potentially atherogenic effect. Atherosclerosis. 2005;179(2):255-259. (Pubitemid 40364618)
28. Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol. 2008;217(3):674-685.
29. Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep. 2004;27(1):123-128. (Pubitemid 43906323)
30. Tan KC, Chow WS, Lam JC, et al. HDL dysfunction in obstructive sleep apnea. Atherosclerosis. 2006;184(2):377-382. (Pubitemid 43049723)
31. Lonn E, Bosch J, Yusuf S, et al HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA. 2005;293(11):1338-1347. (Pubitemid 40381486)
32. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet. 2003;361(9374):2017-2023. (Pubitemid 36695043)
33. Dematteis M, Julien C, Guillermet C, et al. Intermittent hypoxia induces early functional cardiovascular remodeling in mice. Am J Respir Crit Care Med. 2008;177(2):227-235.
34. Jun J, Polotsky VY. Metabolic consequences of sleep-disordered breathing. ILAR J. 2009;50(3):289-306.
35. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med. 2004;169(3):348-353. (Pubitemid 38134813)
36. Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol. 2009;106(5):1538-1544.
37. Fletcher EC, Lesske J, Qian W, Miller CC III, Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension. 1992;19(6 Pt 1):555-561.
38. Shamsuzzaman AS, Winnicki M, Lanfranchi P, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation. 2002;105(21):2462-2464. (Pubitemid 34568964)
39. Drager LF, Lopes HF, Maki-Nunes C, et al. The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome. PLoS One. 2010;5(8):e12065.
40. Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med.2002;165(7):934-939. (Pubitemid 34774660)
41. Ohga E, Tomita T, Wada H, Yamamoto H, Nagase T, Ouchi Y. Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol. 2003;94(1):179-184. (Pubitemid 36014310)
42. Belaidi E, Joyeux-Faure M, Ribuot C, Launois SH, Levy P, Godin-Ribuot D. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. J Am Coll Cardiol. 2009;53(15):1309-1317.
43. Fletcher EC, Bao G, Li R. Renin activity and blood pressure in response to chronic episodic hypoxia. Hypertension.1999;34(2):309-314. (Pubitemid 29409233)
44. Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation. 2005;112(17):2660-2667. (Pubitemid 41532603)
45. de Winther MP, Kanters E, Kraal G, Hofker MH. Nuclear factor kappaB signaling in atherogenesis. Arterioscler Thromb Vasc Biol. 2005;25(5):904-914. (Pubitemid 40627833)
46. Polotsky VY, Savransky V, Bevans-Fonti S, et al. Intermittent and sustained hypoxia induce a similar gene expression profile in the human aortic endothelial cells. Physiol Genomics.2010;41(3):306-314.
47. Jelic S, Lederer DJ, Adams T, et al. Vascular inflammation in obesity and sleep apnea. Circulation. 2010;121(8):1014-1021.
48. Lee SA, Amis TC, Byth K, et al. Heavy snoring as a cause of carotid artery atherosclerosis. Sleep. 2008;31(9):1207-1213.
49. Amatoury J, Howitt L, Wheatley JR, Avolio AP, Amis TC. Snoring-related energy transmission to the carotid artery in rabbits. J Appl Physiol. 2006;100(5):1547-1553.
50. Drager LF, Lorenzi-Filho G. Heavy snoring and carotid atherosclerosis: is there more than an association? Sleep. 2008;31(10):1335.
51. Friedlander AH, Yueh R, Littner MR. The prevalence of calcified carotid artery atheromas in patients with obstructive sleep apnea syndrome. J Oral Maxillofac Surg. 1998;56(8):950-954. (Pubitemid 28374241)
52. Friedlander AH, Friedlander IK, Yueh R, Littner MR. The prevalence of carotid atheromas seen on panoramic radiographs of patients with obstructive sleep apnea and their relation to risk factors for atherosclerosis. J Oral Maxillofac Surg.1999;57(5):516-521.
53. Cilli A, Tatlicioǧlu T, Köktürk O. Nocturnal oxygen desaturation in coronary artery disease. Jpn Heart J. 1999;40(1):23-29. (Pubitemid 29154948)
54. Silvestrini M, Rizzato B, Placidi F, Baruffaldi R, Bianconi A, Diomedi M. Carotid artery wall thickness in patients with obstructive sleep apnea syndrome. Stroke. 2002;33(7):1782-1785. (Pubitemid 34761060)
55. Nachtmann A, Stang A, Wang YM, Wondzinski E, Thilmann AF. Association of obstructive sleep apnea and stenotic artery disease in ischemic stroke patients. Atherosclerosis. 2003;169(2):301-307. (Pubitemid 37297477)
56. Hayashi M, Fujimoto K, Urushibata K, Uchikawa S, Imamura H, Kubo K. Nocturnal oxygen desaturation correlates with the severity of coronary atherosclerosis in coronary artery disease. Chest. 2003;124(3):936-941. (Pubitemid 37123312)
57. Suzuki T, Nakano H, Maekawa J, et al. Obstructive sleep apnea and carotid-artery intima-media thickness. Sleep. 2004;27(1):129-133. (Pubitemid 43906324)
58. Schulz R, Seeger W, Fegbeutel C, et al. Changes in extracranial arteries in obstructive sleep apnoea. Eur Respir J.2005;25(1):69-74. (Pubitemid 40207733)
59. Altin R, Ozdemir H, Mahmutyazicioǧlu K, et al. Evaluation of carotid artery wall thickness with high-resolution sonography in obstructive sleep apnea syndrome. J Clin Ultrasound.2005;33(2):80-86. (Pubitemid 40194417)
60. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med.2005;172(5):613-618. (Pubitemid 41232973)
61. Minoguchi K, Yokoe T, Tazaki T, et al. Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea. Am J Respir Crit Care Med. 2005;172(5):625-630. (Pubitemid 41232975)
62. Tian JL, Zhang Y, Wang Z, Cao L, Chen BY. A study on non-invasive indexes of atherosclerosis in obstructive sleep apnea-hypopnea syndrome patients [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(6):395-398.
63. Tanriverdi H, Evrengul H, Kara CO, et al. Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: non-invasive indicators of atherosclerosis. Respiration. 2006;73(6):741-750. (Pubitemid 44795919)
64. Saletu M, Nosiska D, Kapfhammer G, et al. Structural and serum surrogate markers of cerebrovascular disease in obstructive sleep apnea (OSA): association of mild OSA with early atherosclerosis. J Neurol. 2006;253(6):746-752. (Pubitemid 43980146)
65. Lu G, Xu ZW, Zhang YL, Yang ZJ, Zhang XL, Yin KS. Correlation among obstructive sleep apnea syndrome, coronary atherosclerosis and coronary heart disease. Chin Med J (Engl).2007;120(18):1632-1634. (Pubitemid 47595758)
66. Lu G, Xu ZW, Liu JN, et al. A study on the association of obstructive sleep apnea hypopnea syndrome with coronary atherosclerosis and coronary heart disease [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi. 2007;30(3):178-181.
67. Szabóová E, Tomori Z, Donic V, Petrovicová J, Szabó P. Sleep apnoea inducing hypoxemia is associated with early signs of carotid atherosclerosis in males. Respir Physiol Neurobiol.2007;155(2):121- 127. (Pubitemid 46136103)
68. Dziewas R, Ritter M, Usta N, et al. Atherosclerosis and obstructive sleep apnea in patients with ischemic stroke. Cerebrovasc Dis. 2007;24(1):122-126. (Pubitemid 47026153)
69. Drager LF, Bortolotto LA, Figueiredo AC, Krieger EM, Lorenzi GF. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med. 2007;176(7):706-712. (Pubitemid 47503079)
70. Wattanakit K, Boland L, Punjabi NM, Shahar E. Relation of sleep-disordered breathing to carotid plaque and intima-media thickness. Atherosclerosis. 2008;197(1):125-131. (Pubitemid 351273231)
71. Lefebvre B, Pépin JL, Baguet JP, et al. Leukotriene B4: early mediator of atherosclerosis in obstructive sleep apnoea? Eur Respir J. 2008;32(1):113-120.
72. Saletu M, Sauter C, Lalouschek W, et al. Is excessive daytime sleepiness a predictor of carotid atherosclerosis in sleep apnea? Atherosclerosis. 2008;196(2):810-816.
73. Sorajja D, Gami AS, Somers VK, Behrenbeck TR, Garcia-Touchard A, Lopez-Jimenez F. Independent association between obstructive sleep apnea and subclinical coronary artery disease. Chest. 2008;133(4):927-933. (Pubitemid 351536868)
74. Protogerou AD, Laaban JP, Czernichow S, et al. Structural and functional arterial properties in patients with obstructive sleep apnoea syndrome and cardiovascular comorbidities. J Hum Hypertens. 2008;22(6):415-422. (Pubitemid 351712388)
75. Drager LF, Bortolotto LA, Krieger EM, Lorenzi-Filho G. Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis. Hypertension.2009;53(1):64-69.
76. Baguet JP, Nadra M, Barone-Rochette G, Ormezzano O, Pierre H, Pépin JL. Early cardiovascular abnormalities in newly diagnosed obstructive sleep apnea. Vasc Health Risk Manag. 2009;5:1063-1073.
77. Kong L, Guo XH. The relation between obstructive sleep apnea hypopnea syndrome and the severity of coronary atherosclerosis in coronary artery disease [in Chinese]. Zhonghua Nei Ke Za Zhi. 2009;48(8):638-642.
78. Li C, Zhang XL, Liu H, Wang ZG, Yin KS. Association among plasma interleukin-18 levels, carotid intima-media thickness and severity of obstructive sleep apnea. Chin Med J (Engl).2009;122(1):24-29.
79. Turmel J, Sériès F, Boulet LP, et al. Relationship between atherosclerosis and the sleep apnea syndrome: an intravascular ultrasound study. Int J Cardiol. 2009;132(2):203-209.
80. Kim SH, Cho GY, Baik I, et al. Association of coronary artery calcification with obstructive sleep apnea and obesity in middle-aged men. Nutr Metab Cardiovasc Dis. 2010;20(8):575-582.
81. Monneret D, Pepin JL, Godin-Ribuot D, et al. Association of urinary 15-F2t-isoprostane level with oxygen desaturation and carotid intima-media thickness in nonobese sleep apnea patients. Free Radic Biol Med. 2010;48(4):619-625.
82. Drager LF, Bortolotto LA, Maki-Nunes C, et al. The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis.2010;208(2):490-495.
83. Tsuda H, Almeida FR, Tsuda T, Moritsuchi Y, Lowe AA. Cephalometric calcified carotid artery atheromas in patients with obstructive sleep apnea. Sleep Breath. 2010;14(4):365-370.
84. Yun CH, Jung KH, Chu K, et al. Increased circulating endothelial microparticles and carotid atherosclerosis in obstructive sleep apnea. J Clin Neurol. 2010;6(2):89-98.
85. Prinz C, Bitter T, Piper C, Horstkotte D, Faber L, Oldenburg O. Sleep apnea is common in patients with coronary artery disease. Wien Med Wochenschr. 2010;160(13-14):349-55.
86. Klein C, Martinez D, Hackenhaar FS, et al. Carbonyl groups: bridging the gap between sleep disordered breathing and coronary artery disease. Free Radic Res. 2010;44(8):907-12.
87. Drager LF, Diegues-Silva L, Diniz PM, et al. Obstructive sleep apnea, masked hypertension, and arterial stiffness in men. Am J Hypertens. 2010;23(3):249-254.
88. Drager LF, Pedrosa RP, Diniz PM, et al. The effects of continuous positive airway pressure on prehypertension and masked hypertension in men with severe obstructive sleep apnea. Hypertension. 2011;57(3):549-555.
89. King CR, Knutson KL, Rathouz PJ, Sidney S, Liu K, Lauderdale DS. Short sleep duration and incident coronary artery calcification. JAMA. 2008;300(24):2859-2866.