Long term ablation of protein Kinase a (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 23097-23111

  Dweck, David ^a   Sanchez Gonzalez, Marcos A ^a,b   Chang, Audrey N ^c   Dulce, Raul A ^d   Badger, Crystal Dawn ^a   Koutnik, Andrew P ^a   Ruiz, Edda L ^a   Griffin, Brittany ^a   Liang, Jingsheng ^d   Kabbaj, Mohamed ^a   Fincham, Frank D ^b   Hare, Joshua M ^d   Michael Overton, J ^a   Pinto, Jose R ^a  

^a FLORIDA STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; HEART; PATHOLOGY; PHOSPHORYLATION;

CARDIAC TROPONIN I; DIASTOLIC DYSFUNCTION; DIASTOLIC FUNCTION; ECHOCARDIOGRAPHIC IMAGING; HYPERTROPHIC CARDIOMYOPATHY; SARCOPLASMIC RETICULUM; STEPWISE INCREASE; STIMULATION FREQUENCIES;

MAMMALS;

CALCIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; SODIUM CALCIUM EXCHANGE PROTEIN; TROPONIN I;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DYSAUTONOMIA; ELECTROCARDIOGRAPHY; EXCITATION CONTRACTION COUPLING; HEART MUSCLE CELL; HEART MUSCLE RELAXATION; HYPERTROPHIC CARDIOMYOPATHY; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOMERE; VAGUS TONE; ANIMAL; CALCIUM SIGNALING; DIASTOLE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SARCOPLASMIC RETICULUM; TRANSGENIC MOUSE;

ANIMALS; CALCIUM SIGNALING; CARDIOMYOPATHY, HYPERTROPHIC; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIASTOLE; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PHOSPHORYLATION; SARCOPLASMIC RETICULUM; TROPONIN I;

EID: 84905989264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.561472     Document Type: Article

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