Hydralazine and organic nitrates restore impaired excitation-contraction coupling by reducing calcium leak associated with nitroso-redox imbalance

Journal of Biological Chemistry

Volumn 288, Issue 9, 2013, Pages 6522-6533

  Dulce, Raul A ^a   Yiginer, Omer ^b,c   Gonzalez, Daniel R ^d   Goss, Garrett ^a   Feng, Ning ^c   Zheng, Meizi ^e   Hare, Joshua M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSIDAD DE TALCA   (Chile)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOMYOCYTES; DOSE-DEPENDENT MANNER; EXCITATION-CONTRACTION COUPLING; HEART FAILURE; HYDRALAZINE; INTRACELLULAR CA; ISOSORBIDE; LOW CONCENTRATIONS; MYOCYTE; MYOCYTES; ORGANIC NITRATES; PACING FREQUENCIES; RAT MODEL; SARCOMERE LENGTH; SARCOPLASMIC RETICULUM; SUPEROXIDE PRODUCTION; SUPEROXIDES; UNDERLYING MECHANISM; WILD TYPES; XANTHINE OXIDOREDUCTASE;

CARDIOLOGY; NITRATES; OXYGEN; RESTORATION;

CALCIUM;

GLYCERYL TRINITRATE; HYDRALAZINE; ISOSORBIDE DINITRATE; NEURONAL NITRIC OXIDE SYNTHASE; ORGANIC NITRATE; PHOSPHOSERINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTOLE; DOWN REGULATION; ENZYME ACTIVITY; EXCITATION CONTRACTION COUPLING; HEART FAILURE; HEART MUSCLE CELL; HEART PACING; MOUSE; MUSCLE CONTRACTILITY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOMERE LENGTH; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATION CONTRACTION COUPLING; HYDRALAZINE; MALE; MICE; MICE, KNOCKOUT; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE I; NITROGLYCERIN; OXIDATION-REDUCTION; RATS; RATS, INBRED WKY; SARCOPLASMIC RETICULUM; VASODILATOR AGENTS;

EID: 84874766862     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412130     Document Type: Article

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