Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling

Circulation Research

Volumn 92, Issue 4, 2003, Pages 428-436

  Knollmann, Björn C ^a   Kirchhof, Paulus ^b   Sirenko, Syevda G ^a   Degen, Hubertus ^a   Greene, Anne E ^a   Schober, Tilmann ^a   Mackow, Jessica C ^a   Fabritz, Larissa ^b   Potter, James D ^c   Morad, Martin ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Action potential remodeling; Ca2+ transient; Familial hypertrophic cardiomyopathy; Troponin T; Ventricular tachycardia

Indexed keywords

CALCIUM ION; LITHIUM ION; TROPONIN T;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE MUTATION; GENETIC LINKAGE; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART PERFUSION; HEART REPOLARIZATION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART VENTRICLE TACHYCARDIA; ISOLATED HEART; MENTAL STRESS; MOUSE; MYOFILAMENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CALCIUM EXCHANGE; SUDDEN DEATH; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANESTHESIA; ANIMALS; BLOOD PRESSURE; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; CARDIOTONIC AGENTS; ELECTROCARDIOGRAPHY; GENOTYPE; HEART VENTRICLES; HUMANS; ISOPROTERENOL; MICE; MICE, TRANSGENIC; MUTATION; MYOCYTES, CARDIAC; STRESS, PSYCHOLOGICAL; TACHYCARDIA, VENTRICULAR; TROPONIN T;

EID: 0037423876     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000059562.91384.1A     Document Type: Article

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