Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy

Journal of Biological Chemistry

Volumn 287, Issue 3, 2012, Pages 2156-2167

  Wang, Yingcai ^a   Pinto, Jose Renato ^a   Solis, Raquel Sancho ^b   Dweck, David ^a   Liang, Jingsheng ^a   Diaz Perez, Zoraida ^a   Ge, Ying ^b   Walker, Jeffery W ^b,c   Potter, James D ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; CARDIAC HYPERTROPHY; CARDIAC TROPONIN; CARDIAC TROPONIN I; COMBINED EFFECT; CONSENSUS SEQUENCE; FUNCTIONAL CHARACTERIZATION; HEART DISEASE; HYPERTROPHIC CARDIOMYOPATHY; IN-VIVO; MOUSE MODELS; MUTANT MICE; N-TERMINAL EXTENSION; PROTEIN KINASE A; TOPDOWN;

GENES; HEART; MASS SPECTROMETRY; PATHOLOGY; PHOSPHORYLATION;

MAMMALS;

CALCIUM ION; MUTANT PROTEIN; PROPRANOLOL; SERINE; TROPONIN I;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC ASSOCIATION; HEART MUSCLE FIBROSIS; HETEROZYGOTE; HIGH RESOLUTION TOP DOWN ELECTRON CAPTURE DISSOCIATION MASS SPECTROMETRY; HOMOZYGOTE; HYPERTROPHIC CARDIOMYOPATHY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MOLECULAR PATHOLOGY; MOUSE; MOUSE MUTANT; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKINNED MUSCLE FIBER; SMOOTH MUSCLE TONE; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOMYOCARDIAL FIBROSIS; GENE KNOCK-IN TECHNIQUES; HUMANS; MICE; MICE, MUTANT STRAINS; MUTATION, MISSENSE; MYOCARDIUM; MYOFIBRILS; PHOSPHORYLATION; PROPRANOLOL; TROPONIN I;

MUS;

EID: 84862910102     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.294306     Document Type: Article

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