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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 16, 2014, Pages 3968-3973

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

(11) Flaherty, Daniel P a Simpson, Denise S a Miller, Melissa b,c Maki, Brooks E a Zou, Beiyan b,c Shi, Jie b,c Wu, Meng c McManus, Owen B c Aubé, Jeffrey a Li, Min b,c Golden, Jennifer E a

a UNIVERSITY OF KANSAS (United States)

b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (United States)

c JOHNS HOPKINS UNIVERSITY (United States)

Author keywords

Bis amide; KCNK3; Selective potassium channel inhibitor; TASK1

Indexed keywords

ACID SENSING ION CHANNEL BLOCKING AGENT; AMIDE; PHENYL GROUP; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL 1; UNCLASSIFIED DRUG; KCNK9 PROTEIN, HUMAN; NERVE PROTEIN; POTASSIUM CHANNEL SUBFAMILY K MEMBER 3; TANDEM PORE DOMAIN POTASSIUM CHANNEL; POTASSIUM CHANNEL TASK 1; POTASSIUM CHANNEL TASK 3;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; ELECTROPHYSIOLOGY; IC 50; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; SYNTHESIS; IC50; PROCESS OPTIMIZATION;

AMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905916419 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.06.032 Document Type: Article

Times cited : (42)

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