A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 13977-13984

  Streit, Anne K ^a   Netter, Michael F ^a   Kempf, Franca ^a   Walecki, Magdalena ^a   Rinne, Susanne ^a   Bollepalli, Murali K ^b   Preisig Muller, Regina ^a   Renigunta, Vijay ^a   Daut, Jurgen ^a   Baukrowitz, Thomas ^c   Sansom, Mark S P ^d   Stansfeld, Phillip J ^d   Decher, Niels ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL PORE; DRUG BINDING; EXCITABLE CELLS; EXPERIMENTAL DATA; HOMOLOGY MODELS; MEMBRANE POTENTIALS; OPEN CHANNELS; POTASSIUM CHANNELS; RATIONAL DESIGN; RESPONSE ELEMENTS; STRUCTURAL INSIGHTS;

AMINO ACIDS; ANESTHETICS;

POTASSIUM;

A 1899; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL TASK 1; TANDEM PORE DOMAIN POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HALOTHANE RESPONSIVE ELEMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

ALANINE; ANIMALS; BENZAMIDES; BENZENEACETAMIDES; BINDING SITES; DNA, COMPLEMENTARY; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN CONFORMATION; XENOPUS LAEVIS;

EID: 79954576351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.227884     Document Type: Article

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