Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K 2P9.1 (TASK-3)

ChemMedChem

Volumn 7, Issue 1, 2012, Pages 123-133

  Coburn, Craig A ^a   Luo, Yunfu ^b   Cui, Mingxiang ^b   Wang, Jiabing ^a   Soll, Richard ^b   Dong, Jingchao ^b   Hu, Bin ^b   Lyon, Michael A ^c   Santarelli, Vincent P ^a   Kraus, Richard L ^a   Gregan, Yun ^a   Wang, Yi ^a   Fox, Steven V ^a   Binns, Jacquelyn ^a   Doran, Scott M ^a   Reiss, Duane R ^a   Tannenbaum, Pamela L ^a   Gotter, Anthony L ^a   Meinke, Peter T ^a   Renger, John J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

^c ARRAY BIOPHARMA INC   (United States)

Author keywords

Antagonists; Electroencephalogram (EEG); Neurochemistry; Potassium ion channels; Structure activity relationships; TASK 3

Indexed keywords

5,6,7,8 TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PYRIMIDINE DERIVATIVE; TWO PORE DOMAIN POTASSIUM CHANNEL K2P9.1; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; REM SLEEP; SLEEP PARAMETERS; SLEEP PATTERN; TELEMETRY;

ANIMALS; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PYRIMIDINES; RATS, SPRAGUE-DAWLEY; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84555194825     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100351     Document Type: Article

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