The major cow milk allergen Bos d 5 manipulates T-helper cells depending on its load with siderophore-bound iron

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Roth Walter, Franziska ^a   Pacios, Luis F ^b   Gomez Casado, Cristina ^b   Hofstetter, Gerlinde ^a   Roth, Georg A ^c   Singer, Josef ^d   Diaz Perales, Araceli ^b   Jensen Jarolim, Erika ^a,d  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^b UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BOS D 5 ALLERGEN; CATECHOL; CD4 ANTIGEN; FOOD ALLERGEN; GAMMA INTERFERON; INTERLEUKIN 13; IRON; LUTEOLIN; MYRICETIN; QUERCETIN; SIDEROPHORE; UNCLASSIFIED DRUG; ALLERGEN; BOS D 5 ALLERGEN, BOS TAURUS; FLAVONOID; LIPOCALIN;

ANTIGEN EXPRESSION; ANTIGEN STRUCTURE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; INCUBATION TIME; INFLAMMATION; MILK; MOLECULAR DOCKING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BINDING; SPECTROSCOPY; STAINING; TH2 CELL; ANIMAL; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MILK ALLERGY; MONONUCLEAR CELL;

ALLERGENS; ANIMALS; APOPTOSIS; FLAVONOIDS; HUMANS; IRON; LEUKOCYTES, MONONUCLEAR; LIPOCALINS; LYMPHOCYTE ACTIVATION; MILK; MILK HYPERSENSITIVITY; SIDEROPHORES; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84905836763     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104803     Document Type: Article

References (46)

1. Luyt D, Ball H, Makwana N, Green MR, Bravin K, et al. (2014) BSACI Guideline for the Diagnosis and Management of Cow's Milk Allergy. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology.
2. Jarvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, et al. (2002) B-cell epitopes as a screening instrument for persistent cow's milk allergy. The Journal of allergy and clinical immunology 110: 293-297.
3. Host A (1994) Cow's milk protein allergy and intolerance in infancy. Some clinical, epidemiological and immunological aspects. Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology 5: 1-36.
4. Fiocchi A, Brozek J, Schunemann H, Bahna SL, von Berg A, et al. (2010) World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guidelines. The World Allergy Organization journal 3: 57-161.
5. Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, et al. (2002) The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Molecular cell 10: 1033-1043. (Pubitemid 36001971)
6. Keppler JK, Sonnichsen FD, Lorenzen PC, Schwarz K (2014) Differences in heat stability and ligand binding among beta-lactoglobulin genetic variants A, B and C using H NMR and fluorescence quenching. Biochimica et biophysica acta.
7. Belatik A, Kanakis CD, Hotchandani S, Tarantilis PA, Polissiou MG, et al. (2012) Locating the binding sites of retinol and retinoic acid with milk beta-lactoglobulin. Journal of biomolecular structure & dynamics 30: 437-447.
8. Muresan S, van der Bent A, de Wolf FA (2001) Interaction of beta-lactoglobulin with small hydrophobic ligands as monitored by fluorometry and equilibrium dialysis: nonlinear quenching effects related to protein - protein association. Journal of agricultural and food chemistry 49: 2609-2618. (Pubitemid 32843298)
9. Riihimaki LH, Vainio MJ, Heikura JM, Valkonen KH, Virtanen VT, et al. (2008) Binding of phenolic compounds and their derivatives to bovine and reindeer beta-lactoglobulin. Journal of agricultural and food chemistry 56: 7721-7729.
10. Cowland JB, Borregaard N (1997) Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45: 17-23. (Pubitemid 27449379)
11. Devireddy LR, Gazin C, Zhu X, Green MR (2005) A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123: 1293-1305. (Pubitemid 41821786)
12. Devireddy LR, Teodoro JG, Richard FA, Green MR (2001) Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 293: 829-834. (Pubitemid 32743967)
13. Kehrer JP (2010) Lipocalin-2: pro- or anti-apoptotic? Cell biology and toxicology 26: 83-89.
14. Hider RC, Kong X (2010) Chemistry and biology of siderophores. Natural product reports 27: 637-657.
15. Kontopidis G, Holt C, Sawyer L (2002) The ligand-binding site of bovine beta-lactoglobulin: evidence for a function? Journal of molecular biology 318: 1043-1055. (Pubitemid 35007367)
16. Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, et al. (2009) AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of computational chemistry 30: 2785-2791.
17. Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of computational chemistry 31: 455-461.
18. Ye Y, Godzik A (2003) Flexible structure alignment by chaining aligned fragment pairs allowing twists. Bioinformatics 19 Suppl 2: ii246-255. (Pubitemid 41296662)
19. Kaldjian E, McCarthy SA, Sharrow SO, Littman DR, Klausner RD, et al. (1988) Nonequivalent effects of PKC activation by PMA on murine CD4 and CD8 cell-surface expression. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2: 2801-2806.
20. Miean KH, Mohamed S (2001) Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. Journal of agricultural and food chemistry 49: 3106-3112.
21. Shimoi K, Okada H, Furugori M, Goda T, Takase S, et al. (1998) Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS letters 438: 220-224. (Pubitemid 28529277)
22. Gomez-Casado C, Roth-Walter F, Jensen-Jarolim E, Diaz-Perales A, Pacios LF (2013) Modeling iron-catecholates binding to NGAL protein. Journal of molecular graphics & modelling 45: 111-121.
23. Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E (2005) Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. The Journal of allergy and clinical immunology 116: 869-875. (Pubitemid 41400554)
24. Roth-Walter F, Gomez-Casado C, Pacios LF, Mothes-Luksch N, Roth GA, et al. (2014) Bet v 1 from Birch Pollen is a Lipocalin-like Protein acting as Allergen only when devoid of Iron by promoting Th2 lymphocytes. The Journal of biological chemistry.
25. Parviainen S, Kinnunen T, Rytkonen-Nissinen M, Nieminen A, Liukko A, et al. (2013) Mammal-derived respiratory lipocalin allergens do not exhibit dendritic cell-activating capacity. Scandinavian journal of immunology 77: 171-176.
26. Sanchez D, Ganfornina MD, Gutierrez G, Marin A (2003) Exon-intron structure and evolution of the Lipocalin gene family. Molecular biology and evolution 20: 775-783. (Pubitemid 36539014)
27. Roth-Walter F, Berin MC, Arnaboldi P, Escalante CR, Dahan S, et al. (2008) Pasteurization of milk proteins promotes allergic sensitization by enhancing uptake through Peyer's patches. Allergy 63: 882-890. (Pubitemid 351832791)
28. Kuhnen S, Moacyr JR, Mayer JK, Navarro BB, Trevisan R, et al. (2014) Phenolic content and ferric reducing-antioxidant power of cow's milk produced in different pasture-based production systems in southern Brazil. Journal of the science of food and agriculture.
29. Symonowicz M, Sykula-Zajac A, Lodyga-Chruscinska E, Rumora I, Straukas M (2012) Evaluation of polyphenols and anthocyanins contents in black chockeberry - Photinia melanocarpa (Michx.) fruits extract. Acta poloniae pharmaceutica 69: 381-387.
30. Zhou J, Wang X, Ai T, Cheng X, Guo HY, et al. (2012) Preparation and characterization of beta-lactoglobulin hydrolysate-iron complexes. Journal of dairy science 95: 4230-4236.
31. Wang X, Ai T, Meng XL, Zhou J, Mao XY (2014) In vitro iron absorption of alpha-lactalbumin hydrolysate-iron and beta-lactoglobulin hydrolysate-iron complexes. Journal of dairy science.
32. Jang JT, Green JB, Beard JL, Green MH (2000) Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats. The Journal of nutrition 130: 1291-1296. (Pubitemid 30233282)
33. Suharno D, West CE, Muhilal, Karyadi D, Hautvast JG (1993) Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 342: 1325-1328. (Pubitemid 23345180)
34. Rosales FJ, Jang JT, Pinero DJ, Erikson KM, Beard JL, et al. (1999) Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters. The Journal of nutrition 129: 1223-1228. (Pubitemid 29250175)
35. Akerstrom B, Flower DR, Salier JP (2000) Lipocalins: unity in diversity. Biochimica et biophysica acta 1482: 1-8.
36. Bao G, Clifton M, Hoette TM, Mori K, Deng SX, et al. (2010) Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nature chemical biology 6: 602-609.
37. Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, et al. (2012) Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. Journal of immunology 189: 1911-1919.
38. Xu G, Ahn J, Chang S, Eguchi M, Ogier A, et al. (2012) Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. The Journal of biological chemistry 287: 4808-4817.
39. Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464: 1367-1370.
40. Van Hemelen D, Oude Elberink JN, Bohle B, Heimweg J, Nawijn MC, et al. (2011) Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures. Journal of immunological methods 371: 114-121.
41. Tordesillas L, Cuesta-Herranz J, Gonzalez-Munoz M, Pacios LF, Compes E, et al. (2009) T-cell epitopes of the major peach allergen, Pru p 3: Identification and differential T-cell response of peach-allergic and non-allergic subjects. Molecular immunology 46: 722-728.
42. Illi S, Weber J, Zutavern A, Genuneit J, Schierl R, et al. (2014) Perinatal influences on the development of asthma and atopy in childhood. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 112: 132-139 e131.
43. Elgersma A, Tamminga S, Ellen G (2006) Modifying milk composition through forage. Animal Feed Science and Technology 131: 207-225. (Pubitemid 44693015)
44. Escobar D, Clark S, Ganesan V, Repiso L, Waller J, et al. (2011) High-pressure homogenization of raw and pasteurized milk modifies the yield, composition, and texture of queso fresco cheese. Journal of dairy science 94: 1201-1210.
45. Zurera-Cosano G, Moreno-Rojas R, Amaro-Lopez MA (1994) Effect of processing on contents and relationships of mineral elements of milk. Food Chemistry 51: 75-78. (Pubitemid 24244914)
46. Waser M, Michels KB, Bieli C, Floistrup H, Pershagen G, et al. (2007) Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology 37: 661-670.