Mammal-derived respiratory lipocalin allergens do not exhibit dendritic cell-activating capacity

Scandinavian Journal of Immunology

Volumn 77, Issue 3, 2013, Pages 171-176

  Parviainen, S ^a   Kinnunen, T ^a   Rytkonen Nissinen M ^a   Nieminen, A ^a   Liukko, A ^a   Virtanen, T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CELL SURFACE MARKER; ENDOTOXIN; LIPOCALIN; LIPOPOLYSACCHARIDE; RECOMBINANT ALLERGEN;

ALLERGENICITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INNATE IMMUNITY; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL;

ALLERGENS; ANIMALS; CATTLE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; DOGS; FLOW CYTOMETRY; GLYCOPROTEINS; HORSES; HUMANS; LIPOCALINS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84875633122     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12023     Document Type: Article

References (27)

1. Virtanen T, Kinnunen T. Mammalian allergens. In: Lockey RF, Ledford DK, eds. Allergens and Allergen Immunotherapy, 4th edn. New York: Informa Healthcare USA, Inc., 2008:201-18. ISBN-10: 1-4200-6197-6 and ISBN-13: 978-1-4200-6197-0.
2. Virtanen T, Kinnunen T, Rytkonen-Nissinen M. Mammalian lipocalin allergens - insights into their enigmatic allergenicity. Clin Exp Allergy 2012;42:494-504.
3. Dandeu JP, Rabillon J, Divanovic A, Carmi-Leroy A, David B. Hydrophobic interaction chromatography for isolation and purification of Equ.c1, the horse major allergen. J Chromatogr - Biomed Appl 1993;621:23-31.
4. Saarelainen S, Rytkönen-Nissinen M, Rouvinen J et al. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. Clin Exp Allergy 2008;38:374-81.
5. Ylönen J, Mäntyjärvi R, Taivainen A, Virtanen T. IgG and IgE antibody responses to cow dander and urine in farmers with cow-induced asthma. Clin Exp Allergy 1992;22:83-90.
6. Zeiler T, Mäntyjärvi R, Rautiainen J et al. T cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule. J Immunol 1999;162:1415-22.
7. Saarelainen S, Zeiler T, Rautiainen J et al. Lipocalin allergen Bos d 2 is a weak immunogen. Int Immunol 2002;14:401-9.
8. Immonen A, Saarelainen S, Rautiainen J et al. Probing the mechanisms of low immunogenicity of a lipocalin allergen, Bos d 2, in a mouse model. Clin Exp Allergy 2003;33:834-41.
9. Kinnunen T, Buhot C, Närvänen A et al. The immunodominant epitope of lipocalin allergen Bos d 2 is suboptimal for human T cells. Eur J Immunol 2003;33:1717-26.
10. Jeal H, Draper A, Harris J et al. Determination of the T cell epitopes of the lipocalin allergen, Rat n 1. Clin Exp Allergy 2004;34:1919-25.
11. Immonen A, Farci S, Taivainen A et al. T cell epitope-containing peptides of the major dog allergen Can f 1 as candidates for allergen immunotherapy. J Immunol 2005;105:3614-20.
12. Kinnunen T, Taivainen A, Partanen J et al. The DR4-DQ8 haplotype and a specific TCR Vbeta T-cell subset are associated with absence of allergy to Can f 1. Clin Exp Allergy 2005;35:797-803.
13. Immonen A, Kinnunen T, Sirven P et al. The horse major allergen Equ c 1 contains one immunodominant region of T cell epitopes. Clin Exp Allergy 2007;37:939-47.
14. Reed CE, Kita H. The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 2004;114:997-1008.
15. Sokol CL, Medzhitov R. Role of basophils in the initiation of Th2 responses. Curr Opin Immunol 2010;22:73-7.
16. Shreffler WG, Castro RR, Kucuk ZY et al. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol 2006;177:3677-85.
17. Hammad H, Chieppa M, Perros F et al. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009;15:410-6.
18. Eisenbarth SC, Piggott DA, Huleatt JW et al. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002;196:1645-51.
19. Traidl-Hoffmann C, Mariani V, Hochrein H et al. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med 2005;201:627-36.
20. Gilles S, Mariani V, Bryce M et al. Pollen-derived E1-phytoprostanes signal via PPAR-gamma and NF-kappaB-dependent mechanisms. J Immunol 2009;182:6653-8.
21. Rautiainen J, Auriola S, Rouvinen J et al. Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family. Biochem Biophys Res Commun 1998;247:746-50.
22. Paul WE, Zhu J. How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol 2010;10:225-35.
23. Zeiler T, Taivainen A, Rytkönen M et al. Recombinant allergen fragments as candidate preparations for allergen immunotherapy. J Allergy Clin Immunol 1997;100:721-7.
24. Parviainen S, Taivainen A, Liukko A et al. Comparison of the allergic and nonallergic CD4 + T-cell responses to the major dog allergen Can f 1. J Allergy Clin Immunol 2010;126:406-8.
25. Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K et al. Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J Allergy Clin Immunol 2009;123:239-48.
26. Lambrecht BN, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010;376:835-43.
27. Trompette A, Divanovic S, Visintin A et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009;457:585-8.