Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma

Immunologic Research

Volumn 59, Issue 1-3, 2014, Pages 188-202

  Rosean, Timothy R ^a   Tompkins, Van S ^a   Tricot, Guido ^a,b   Holman, Carol J ^a,b   Olivier, Alicia K ^a   Zhan, Fenghuang ^a,b   Janz, Siegfried ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Genetically engineered mouse models of human myeloma; IL 6 signaling in neoplastic plasma cells; Myeloma stem cells and minimal residual disease; Small drug and monoclonal antibody based inhibitors

Indexed keywords

INTERLEUKIN 6; ANTINEOPLASTIC AGENT; IL6 PROTEIN, HUMAN;

CANCER GROWTH; CELL PROLIFERATION; CELL SURVIVAL; GENETICALLY ENGINEERED MOUSE STRAIN; MINIMAL RESIDUAL DISEASE; MOUSE; MULTIPLE MYELOMA; NONHUMAN; OSTEOCLASTOGENESIS; PLASMACYTOMA; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VALIDATION STUDY; ANIMAL; ART; DRUG EFFECTS; DRUG SCREENING; HUMAN; IMMUNOLOGY; PATHOLOGY; PLASMA CELL; TUMOR MICROENVIRONMENT;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTERLEUKIN-6; MULTIPLE MYELOMA; PLASMA CELLS; PORTRAITS AS TOPIC; TUMOR MICROENVIRONMENT;

EID: 84905747312     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-014-8528-x     Document Type: Review

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