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Volumn 3, Issue 9, 2013, Pages

Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CANCER SURVIVOR; CELL EXPANSION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DONOR; FEMALE; FOLLOW UP; HUMAN; IN VITRO STUDY; LONG TERM SURVIVAL; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; REGULATORY T LYMPHOCYTE; TH17 CELL;

EID: 84885350915     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2013.34     Document Type: Article
Times cited : (118)

References (48)
  • 1
    • 0022357528 scopus 로고
    • Ten-year survival in multiple myeloma
    • DOI 10.1001/archinte.145.11.2073
    • Alexanian R. Ten-year survival in multiple myeloma. Arch Intern Med 1985; 145: 2073-2074. (Pubitemid 16198409)
    • (1985) Archives of Internal Medicine , vol.145 , Issue.11 , pp. 2073-2074
    • Alexanian, R.1
  • 3
    • 0027105278 scopus 로고
    • Ten-year survival in multiple myeloma: Report of two cases and review of the literature
    • Rosner F, Grunwald HW, Kalman AC. Ten-year survival in multiple myeloma: report of two cases and review of the literature. N Y State J Med 1992; 92: 316-318. (Pubitemid 23052755)
    • (1992) New York State Journal of Medicine , vol.92 , Issue.7 , pp. 316-318
    • Rosner, F.1    Grunwald, H.W.2    Kalman, A.C.3
  • 5
    • 79959243080 scopus 로고    scopus 로고
    • Long-term follow-up of a comparison of nonmyeloablative allografting with autografting for newly diagnosed myeloma
    • Giaccone L, Storer B, Patriarca F, Rotta M, Sorasio R, Allione B et al. Long-term follow-up of a comparison of nonmyeloablative allografting with autografting for newly diagnosed myeloma. Blood 2011; 117: 6721-6727.
    • (2011) Blood , Issue.117 , pp. 6721-6727
    • Giaccone, L.1    Storer, B.2    Patriarca, F.3    Rotta, M.4    Sorasio, R.5    Allione, B.6
  • 7
    • 0345599884 scopus 로고    scopus 로고
    • Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy
    • DOI 10.1084/jem.20031030
    • Dhodapkar MV, Krasovsky J, Osman K, Geller MD. Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy. J Exp Med 2003; 198: 1753-1757. (Pubitemid 37494167)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.11 , pp. 1753-1757
    • Dhodapkar, M.V.1    Krasovsky, J.2    Osman, K.3    Geller, M.D.4
  • 8
    • 0028150642 scopus 로고
    • Multiple myeloma: Why does the disease escape from plateau phase?
    • Joshua DE, Brown RD, Gibson J. Multiple myeloma: why does the disease escape from plateau phase? Br J Haematol 1994; 88: 667-671. (Pubitemid 24375778)
    • (1994) British Journal of Haematology , vol.88 , Issue.4 , pp. 667-671
    • Joshua, D.E.1    Brown, R.D.2    Gibson, J.3
  • 9
    • 0030923576 scopus 로고    scopus 로고
    • The prognostic significance of T cell receptor β gene rearrangements and idiotype-reactive T cells in multiple myeloma
    • Brown RD, Yuen E, Nelson M, Gibson J, Joshua D. The prognostic significance of T cell receptor beta gene rearrangements and idiotype-reactive T cells in multiple myeloma. Leukemia 1997; 11: 1312-1317. (Pubitemid 27387309)
    • (1997) Leukemia , vol.11 , Issue.8 , pp. 1312-1317
    • Brown, R.D.1    Yuen, E.2    Nelson, M.3    Gibson, J.4    Joshua, D.5
  • 10
    • 71049147113 scopus 로고    scopus 로고
    • Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma
    • Brown RD, Spencer A, Ho PJ, Kennedy N, Kabani K, Yang S et al. Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma. Leuk Lymphoma 2009; 50: 1860-1864.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1860-1864
    • Brown, R.D.1    Spencer, A.2    Ho, P.J.3    Kennedy, N.4    Kabani, K.5    Yang, S.6
  • 12
    • 77951740292 scopus 로고    scopus 로고
    • Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenstrom macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy
    • Li J, Sze DM, Brown RD, Cowley MJ, Kaplan W, Mo SL et al. Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenstrom macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy. Blood 2010; 115: 3580-3588.
    • (2010) Blood , Issue.115 , pp. 3580-3588
    • Li, J.1    Sze, D.M.2    Brown, R.D.3    Cowley, M.J.4    Kaplan, W.5    Mo, S.L.6
  • 17
    • 0035525736 scopus 로고    scopus 로고
    • Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartment
    • Sze DM, Giesajtis G, Brown RD, Raitakari M, Gibson J, Ho J et al. Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartment. Blood 2001; 98: 2817-2827.
    • (2001) Blood , vol.98 , pp. 2817-2827
    • Sze, D.M.1    Giesajtis, G.2    Brown, R.D.3    Raitakari, M.4    Gibson, J.5    Ho, J.6
  • 18
    • 0041660895 scopus 로고    scopus 로고
    • The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    • DOI 10.1084/jem.20030107
    • D'Amico A, Wu L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med 2003; 198: 293-303. (Pubitemid 36987854)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.2 , pp. 293-303
    • D'Amico, A.1    Wu, L.2
  • 19
    • 28844462429 scopus 로고    scopus 로고
    • +T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden
    • DOI 10.1182/blood-2005-02-0563
    • Goodyear O, Piper K, Khan N, Starczynski J, Mahendra P, Pratt G et al. CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden. Blood 2005; 106: 4217-4224. (Pubitemid 41775929)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4217-4224
    • Goodyear, O.1    Piper, K.2    Khan, N.3    Starczynski, J.4    Mahendra, P.5    Pratt, G.6    Moss, P.7
  • 20
    • 34248194231 scopus 로고    scopus 로고
    • Tregs and rethinking cancer immunotherapy
    • DOI 10.1172/JCI31202
    • Curiel TJ. Tregs and rethinking cancer immunotherapy. J Clin Invest 2007; 117: 1167-1174. (Pubitemid 46718401)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1167-1174
    • Curiel, T.J.1
  • 23
    • 73249126730 scopus 로고    scopus 로고
    • The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells
    • Law JP, Hirschkorn DF, Owen RE, Biswas HH, Norris PJ, Lanteri MC. The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells. Cytometry Part A 2009; 75: 1040-1050.
    • (2009) Cytometry Part A , vol.75 , pp. 1040-1050
    • Law, J.P.1    Hirschkorn, D.F.2    Owen, R.E.3    Biswas, H.H.4    Norris, P.J.5    Lanteri, M.C.6
  • 24
    • 62549095932 scopus 로고    scopus 로고
    • Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4+Foxp3+ T cells
    • Minnema MC, van der Veer MS, Aarts T, Emmelot M, Mutis T, Lokhorst HM. Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4+Foxp3+ T cells. Leukemia 2009; 23: 605-607.
    • (2009) Leukemia , vol.23 , pp. 605-607
    • Minnema, M.C.1    Van Der Veer, M.S.2    Aarts, T.3    Emmelot, M.4    Mutis, T.5    Lokhorst, H.M.6
  • 25
    • 77956581743 scopus 로고    scopus 로고
    • The cytokine/ chemokine pattern in the bone marrow environment of multiple myeloma patients
    • Cao Y, Luetkens T, Kobold S, Hildebrandt Y, Gordic M, Lajmi N et al. The cytokine/ chemokine pattern in the bone marrow environment of multiple myeloma patients. Exp Hematol 2010; 38: 860-867.
    • (2010) Exp Hematol , vol.38 , pp. 860-867
    • Cao, Y.1    Luetkens, T.2    Kobold, S.3    Hildebrandt, Y.4    Gordic, M.5    Lajmi, N.6
  • 26
    • 64649083365 scopus 로고    scopus 로고
    • Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure
    • Spencer A, Prince HM, Roberts AW, Prosser IW, Bradstock KF, Coyle L et al. Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure. J Clin Oncol 2009; 27: 1788-1793.
    • (2009) J Clin Oncol , vol.27 , pp. 1788-1793
    • Spencer, A.1    Prince, H.M.2    Roberts, A.W.3    Prosser, I.W.4    Bradstock, K.F.5    Coyle, L.6
  • 27
    • 0032100486 scopus 로고    scopus 로고
    • Thalidomide costimulates primary human t lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset
    • DOI 10.1084/jem.187.11.1885
    • Haslett PA, Corral LG, Albert M, Kaplan G. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. J Exp Med 1998; 187: 1885-1892. (Pubitemid 28262451)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.11 , pp. 1885-1892
    • Haslett, P.A.J.1    Corral, L.G.2    Albert, M.3    Kaplan, G.4
  • 28
    • 58849093606 scopus 로고    scopus 로고
    • CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+) CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
    • Feyler S, von Lilienfeld-Toal M, Jarmin S, Marles L, Rawstron A, Ashcroft AJ et al. CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+) CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden. Br J Haematol 2009; 144: 686-695.
    • (2009) Br J Haematol , vol.144 , pp. 686-695
    • Feyler, S.1    Von Lilienfeld-Toal, M.2    Jarmin, S.3    Marles, L.4    Rawstron, A.5    Ashcroft, A.J.6
  • 29
    • 0028784287 scopus 로고
    • B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset
    • Galy A, Travis M, Cen D, Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 1995; 3: 459-473.
    • (1995) Immunity , vol.3 , pp. 459-473
    • Galy, A.1    Travis, M.2    Cen, D.3    Chen, B.4    Human, T.5
  • 31
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999; 401: 86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 32
    • 0034720166 scopus 로고    scopus 로고
    • Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
    • DOI 10.1038/35010121
    • Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K et al. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Nature 2000; 404: 999-1003. (Pubitemid 30243594)
    • (2000) Nature , vol.404 , Issue.6781 , pp. 999-1003
    • Kawabuchi, M.1    Satomi, Y.2    Takao, T.3    Shimonishi, Y.4    Nada, S.5    Nagal, K.6    Tarakhovsky, A.7    Okada, M.8
  • 34
    • 0032996623 scopus 로고    scopus 로고
    • C-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points
    • Mateyak MK, Obaya AJ, Sedivy JM. c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol 1999; 19: 4672-4683. (Pubitemid 29289505)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.7 , pp. 4672-4683
    • Mateyak, M.K.1    Obaya, A.J.2    Sedivy, J.M.3
  • 35
    • 0032546961 scopus 로고    scopus 로고
    • Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP)
    • DOI 10.1074/jbc.273.25.15340
    • Saxena M, Williams S, Gilman J, Mustelin T. Negative regulation of T cell antigen receptor signal transduction by hematopoietic tyrosine phosphatase (HePTP). J Bioll Chem 1998; 273: 15340-15344. (Pubitemid 28298136)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.25 , pp. 15340-15344
    • Saxena, M.1    Williams, S.2    Gilman, J.3    Mustelin, T.4
  • 38
    • 84856423569 scopus 로고    scopus 로고
    • The frequency of T regulatory cells modulates the survival of multiple myeloma patients: Detailed characterisation of immune status in multiple myeloma
    • Giannopoulos K, Kaminska W, Hus I, Dmoszynska A. The frequency of T regulatory cells modulates the survival of multiple myeloma patients: detailed characterisation of immune status in multiple myeloma. Br J Cancer 2012; 106: 546-552.
    • (2012) Br J Cancer , Issue.106 , pp. 546-552
    • Giannopoulos, K.1    Kaminska, W.2    Hus, I.3    Dmoszynska, A.4
  • 40
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • DOI 10.1084/jem.193.2.233
    • Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001; 193: 233-238. (Pubitemid 32524454)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.2 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 42
    • 33747622050 scopus 로고    scopus 로고
    • Dendritic cells and tumor microenvironment: A dangerous liaison
    • DOI 10.1080/08820130600803429, PII M1855166164075X7
    • Fricke I, Gabrilovich DI. Dendritic cells and tumor microenvironment: a dangerous liaison. Immunol Invest 2006; 35: 459-483. (Pubitemid 44266783)
    • (2006) Immunological Investigations , vol.35 , Issue.3-4 , pp. 459-483
    • Fricke, I.1    Gabrilovich, D.I.2
  • 44
    • 84872087150 scopus 로고    scopus 로고
    • Analysis of the immune system of multiple myeloma patients achieving long-term disease control, by multidimensional flow cytometry
    • Pessoa-Magalhaes RJ, Vidriales MB, Paiva B, Gimenez CF, Garcia-Sanz R, Mateos MV et al. Analysis of the immune system of multiple myeloma patients achieving long-term disease control, by multidimensional flow cytometry. Haematologica 2013; 98: 79-86.
    • (2013) Haematologica , Issue.98 , pp. 79-86
    • Pessoa-Magalhaes, R.J.1    Vidriales, M.B.2    Paiva, B.3    Gimenez, C.F.4    Garcia-Sanz, R.5    Mateos, M.V.6
  • 46
    • 84862695017 scopus 로고    scopus 로고
    • Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
    • Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol 2012; 181: 8-18.
    • (2012) Am J Pathol , Issue.181 , pp. 8-18
    • Maddur, M.S.1    Miossec, P.2    Kaveri, S.V.3    Bayry, J.4
  • 47
    • 77955862810 scopus 로고    scopus 로고
    • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
    • Prabhala RH, Pelluru D, Fulciniti M, Prabhala HK, Nanjappa P, Song W et al. Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma. Blood 2010; 115: 5385-5392.
    • (2010) Blood , Issue.115 , pp. 5385-5392
    • Prabhala, R.H.1    Pelluru, D.2    Fulciniti, M.3    Prabhala, H.K.4    Nanjappa, P.5    Song, W.6
  • 48
    • 78149322663 scopus 로고    scopus 로고
    • A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    • Noonan K, Marchionni L, Anderson J, Pardoll D, Roodman GD, Borrello I. A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 2010; 116: 3554-3563.
    • (2010) Blood , Issue.116 , pp. 3554-3563
    • Noonan, K.1    Marchionni, L.2    Anderson, J.3    Pardoll, D.4    Roodman, G.D.5    Borrello, I.6


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