Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 25, 2003, Pages 14982-14987

  Bliskovsky, Valery ^a   Ramsay, Edward S ^a   Scott, John ^a   DuBois, Wendy ^a   Shi, Wei ^a   Zhang, Shuling ^a   Qian, Xiaolan ^a   Lowy, Douglas R ^a   Mock, Beverly A ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; FKBP12 RAPAMYCIN ASSOCIATED PROTEIN; GENE PRODUCT; PHOSPHOTRANSFERASE; RAPAMYCIN DERIVATIVE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ALLELISM; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EUKARYOSIS; GENE; GENE IDENTIFICATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PCTR2 GENE; PLASMACYTOMA; PRIORITY JOURNAL; THERMOSTABILITY; TUMOR SUPPRESSOR GENE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA; GENES, TUMOR SUPPRESSOR; GENOTYPE; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLASMACYTOMA; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SIROLIMUS; TIME FACTORS;

ANIMALIA; EUKARYOTA;

EID: 0345598882     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2431627100     Document Type: Article

References (57)

1. Potter, M. (1972) Phys. Rev. 52, 631-719.
2. Hilbert, D. M., Kopf, M., Mock, B. A., Kohler, G. & Rudikoff, S. (1995) J. Exp. Med. 182, 243-248.
3. Nordan, R. P. & Potter, M. (1986) Science 233, 566-569.
4. Morse, H. C., III, Hartley, J. W. & Potter, M. (1980) in Progress in Myeloma, ed. Potter, M. (Elsevier, Amsterdam), pp. 263-279.
5. Mock, B. A., Krall, M. A. & Dosik, J. K. (1993) Proc. Natl. Acad. Sci. USA 90, 9499-9503.
6. Potter, M., Mushinski, E. B., Wax, J. S., Hartley, J. & Mock, B. (1994) Cancer Res. 54, 969-975.
7. Mock, B. A., Hartley, J., Le Tissier, P., Wax, J. S. & Potter, M. (1997) Blood 90, 4092-4098.
8. Zhang, S., Ramsay, E. S. & Mock, B. A. (1998) Proc. Natl. Acad. Sci. USA 95, 2429-2434.
9. Zhang, S. L., DuBois, W., Ramsay, E. S., Bliskovski, V., Morse, H. C., III, Taddesse-Heath, L., Vass, W. C., DePinho, R. A. & Mock, B. A. (2001) Mol. Cell. Biol. 21, 310-318.
10. Zhang, S. & Mock, B. A. (1999) Curr. Top. Microbiol. Immunol. 246, 363-368.
11. Zhang, S., Qian, X., Redman, C., Bliskovski, V., Ramsay, E. S., Lowy, D. R. & Mock, B. A. (2003) Oncogene 22, 2285-2295.
12. Sabatini, D., Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S. H. (1994) Cell 78, 35-43.
13. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B. & Schreiber, S. L. (1995) Nature 377, 441-446.
14. Abraham, R. T. (1998) Curr. Opin. Immunol. 10, 330-336.
15. Gingras, A.-C., Kennedy, S. G., O'Leary, M. A., Sonenberg, N. & Hay, N. (1998) Genes Dev. 12, 502-513.
16. Chen, J., Peterson, R. T. & Schreiber, S. L. (1998) Biochem. Biophys. Res. Commun. 247, 827-832.
17. Yokogami, K., Wakisaka, S., Avruch, J. & Reeves, S. A. (1999) Curr. Biol. 10, 47-50.
18. Gingras, A.-C., Baught, B. & Sonenberg, N. (2001) Genes Dev. 15, 807-826.
19. Hartman, M. E., Villela-Bach, M., Chen, J. & Freund, G. G. (2001) Biochem. Biophys. Res. Commun. 280, 776-781.
20. Badache, A. & Hynes, N. E. (2001) Cancer Res. 61, 383-391.
21. Klein, B., Zhang, X., Jourdan, M., Boiron, J., Portier, M., Lu, Z., Wijdenes, J., Brochier, J. & Bataille, R. (1990) Eur. Cytokine Network 1, 193-201.
22. Shimizu, S., Yoshioka, R., Hirose, Y., Sugai, S., Tachibana, J. & Konda, S. (1989) J. Exp. Med. 169, 339-344.
23. Schmelzle, T. & Hall, M. N. (2000) Cell 103, 253-262.
24. Willumsen, B. M., Vass, W. C., Velu, T. J., Papageorge, A. G., Schiller, J. & Lowy, D. R. (1991) Mol. Cell. Biol. 9, 6026-6033.
25. Ilyin, G. P., Rialland, M., Pigeon, C. & Guguen-Guillouzo, C. (2000) Genomics 67, 40-47.
26. Thiel, S., Vorup-Jensen, T., Strover, C. M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U., Reid, K. B. M. & Jensenius, J. (1997) Nature 386, 506-510.
27. Takahashi, M., Endo, Y., Fujita, T. & Matsushita, M. (1999) Int. Immun. 11, 859-863.
28. Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S. & Schreiber, S. L. (1994) Nature 369, 756-758.
29. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C. & Abraham, R. T. (1997) Science 277, 99-101.
30. Hara, K., Yonezawa, K., Kozlowski, M. T., Sugimoto, T., Andrabi, T., Weng, Q. P., Kauga, M., Nishimoto, I. & Avruch, J. (1997) J. Biol. Chem. 272, 26457-26463.
31. Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H. & Sabatini, D. (1998) Proc. Natl. Acad. Sci. USA 95, 1432-1437.
32. Yarosh, D. B., Cruz, P. D., Dougherty, I., Bizios, N., Kibitel, J., Goodtzova, K., Both, D., Goldfarb, S., Green, B. & Brown, D. (2000) J. Invest. Dermatol. 114, 1005-1010.
33. Kaighn, M. E., Narayan, K. S., Ohnuki, Y., Lechner, J. F. & Jones, L. W. (1979) Invest. Urol. 17, 16-23.
34. Louie, K. G., Behrens, B. C., Kinsella, T. J., Hamilton, T. C., Grotzinger, K. R., McKoy, W. F., Winker, M. A. & Ozols, R. F. (1985) Cancer Res. 45, 2110-2115.
35. Loreni, F., Thomas, G. & Amaldi, F. (2000) Eur. J. Biochem. 267, 6594-6601.
36. Abraham, R. T. & Wiederrecht, G. (1996) Annu. Rev. Immunol. 14, 483-510.
37. Dudkin, L., Dilling, M. B., Cheshire, P. J., Harwood, F. C., Hollingshead, M., Arbuck, S. G., Travis, R., Sausville, E. A. & Houghton, P. J. (2001) Clin. Cancer Res. 7, 1758-1764.
38. Huang, S. & Houghton, P. J. (2002) Curr. Opin. Invest. Drugs 3, 295-304.
39. Perry, J. & Kleckner, N. (2003) Cell 112, 151-155.
40. Sabatini, D. M., Barrow, R. K., Blackshaw, S., Burnett, P. E., Lai, M. M., Field, M. E., Bahr, B. A., Kirsch, J., Betz, H. & Snyder, S. H. (1994) Science 284, 1161-1164.
41. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J. & Yonezawa, K. (2002) Cell 110, 177-189.
42. Kim, D.-H., Sarbassov, D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P. & Sabatini, D. (2002) Cell 110, 163-175.
43. Choi, J. H., Bertram, P. G., Drenan, R., Carvalho, J., Zhou, H. H. & Zheng, X. F. S. (2002) EMBO Rep. 3, 988-994.
44. Balint, E. E. & Vousden, K. H. (2001) Br. J. Cancer 85, 1813-1823.
45. Aoki, M., Blazek, E. & Vogt, P. K. (2001) Proc. Natl. Acad. Sci. USA 98, 136-141.
46. Balcarcel, R. R. & Stephanopoulos, G. (2001) Biotechnol. Bioeng. 76, 1-10.
47. Pene, F., Claessens, Y.-E., Muller, O., Viguie, F., Mayeux, P., Dreyfus, F., Lacombe, C. & Bouscary, D. (2002) Oncogene 21, 6587-6597.
48. Weissinger, E. M., Mischak, H., Goodnight, J., Davidson, W. F. & Mushinski, J. F. (1993) Mol. Cell. Biol. 13, 2578-2585.
49. Wiener, F., Coleman, A., Mock, B. A. & Potter, M. (1995) Cancer Res. 55, 1181-1188.
50. Kumar, V., Sabatini, D., Pandey, P., Gingras, A.-C., Majumder, P. K., Kumar, M., Yuan, Z.-M., Carmichael, G., Weichselbaum, R., Sonenberg, N., et al. (2000) J. Biol. Chem. 275, 10779-10787.
51. Wakefield, L. M. & Roberts, A. B. (2002) Curr. Opin. Genet. Dev. 12, 22-29.
52. Akhurst, R. J. (2002) J. Clin. Invest. 109, 1533-1536.
53. Rounbehler, R. J., Rogers, P. M., Conti, C. J. & Johnson, D. G. (2002) Cancer Res. 11, 3276-3281.
54. Derynck, R., Akhurst, R. J. & Balmain, A. (2001) Nat. Genet. 29, 117-129.
55. Pierce, A. M., Gimenez-Conti, I. B., Schneider-Broussard, R., Martinez, L. A., Conti, C. J. & Johnson, D. G. (1998) Proc. Natl. Acad. Sci. USA 95, 8858-8863.
56. Pierce, A. M., Schneider-Broussard, R., Gimenez-Conti, I. B., Russell, J. L., Conti, C. J. & Johnson, D. G. (1999) Mol. Cell. Biol. 19, 6408-6414.
57. Conner, E. A., Lemmer, E. R., Omori, M., Wirth, P. J., Factor, V. M. & Thorgiersson, S. S. (2000) Oncogene 19, 5054-5062.