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Volumn 99, Issue 4, 2014, Pages 361-371

Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies

Author keywords

Adoptive T cell therapy; CAR; Hematologic malignancies

Indexed keywords

CARMUSTINE; CD19 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FLUDARABINE; LYMPHOCYTE ANTIGEN RECEPTOR; MELPHALAN; RITUXIMAB; UNCLASSIFIED DRUG; HYBRID PROTEIN;

EID: 84899656300     PISSN: 09255710     EISSN: 18653774     Source Type: Journal    
DOI: 10.1007/s12185-013-1479-5     Document Type: Review
Times cited : (91)

References (51)
  • 1
    • 0037264471 scopus 로고    scopus 로고
    • Targeting tumours with genetically enhanced T lymphocytes
    • DOI 10.1038/nrc971
    • Sadelain M, Riviere I, Brentjens R. Targeting tumours with genetically enhanced T lymphocytes. Nat Rev Cancer. 2003;3:35-45. (Pubitemid 37328885)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 35-45
    • Sadelain, M.1    Riviere, I.2    Brentjens, R.3
  • 2
    • 84877666359 scopus 로고    scopus 로고
    • How do CARs work? Early insights from recent clinical studies targeting CD19
    • Davila ML, Brentjens R, Wang X, Riviere I, Sadelain M. How do CARs work?: early insights from recent clinical studies targeting CD19. Oncoimmunology. 2012;1:1577-83.
    • (2012) Oncoimmunology , vol.1 , pp. 1577-1583
    • Davila, M.L.1    Brentjens, R.2    Wang, X.3    Riviere, I.4    Sadelain, M.5
  • 3
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. The basic principles of chimeric antigen receptor design. Cancer Discov. 2013;3:388-98.
    • (2013) Cancer Discov , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 4
    • 79955517235 scopus 로고    scopus 로고
    • CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    • Savoldo B, Ramos CA, Liu E, Mims MP, Keating MJ, Carrum G, et al. CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients. J Clin Invest. 2011;121:1822-6.
    • (2011) J Clin Invest , vol.121 , pp. 1822-1826
    • Savoldo, B.1    Ramos, C.A.2    Liu, E.3    Mims, M.P.4    Keating, M.J.5    Carrum, G.6
  • 5
    • 77955510549 scopus 로고    scopus 로고
    • Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans
    • Jensen MC, Popplewell L, Cooper LJ, DiGiusto D, Kalos M, Ostberg JR, et al. Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans. Biol Blood Marrow Transplant. 2010;16:1245-56.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 1245-1256
    • Jensen, M.C.1    Popplewell, L.2    Cooper, L.J.3    DiGiusto, D.4    Kalos, M.5    Ostberg, J.R.6
  • 6
    • 78549278144 scopus 로고    scopus 로고
    • Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    • Kochenderfer JN, Wilson WH, Janik JE, Dudley ME, Stetler-Stevenson M, Feldman SA, et al. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood. 2010;116:4099-102.
    • (2010) Blood , vol.116 , pp. 4099-4102
    • Kochenderfer, J.N.1    Wilson, W.H.2    Janik, J.E.3    Dudley, M.E.4    Stetler-Stevenson, M.5    Feldman, S.A.6
  • 7
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 2012;119:2709-20.
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3    Wilson, W.H.4    Spaner, D.E.5    Maric, I.6
  • 8
    • 80051775476 scopus 로고    scopus 로고
    • T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia
    • Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med. 2011;3:95ra73.
    • (2011) Sci Transl Med , vol.3
    • Kalos, M.1    Levine, B.L.2    Porter, D.L.3    Katz, S.4    Grupp, S.A.5    Bagg, A.6
  • 9
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 2011;365:725-33.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 10
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens RJ, Riviere I, Park JH, Davila ML, Wang X, Stefanski J, et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 2011;118:4817-28.
    • (2011) Blood , vol.118 , pp. 4817-4828
    • Brentjens, R.J.1    Riviere, I.2    Park, J.H.3    Davila, M.L.4    Wang, X.5    Stefanski, J.6
  • 11
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia
    • Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med. 2013;5:177ra138.
    • (2013) Sci Transl Med , vol.5
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3    Park, J.4    Wang, X.5    Cowell, L.G.6
  • 13
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li YS, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 1993;178:951-60. (Pubitemid 23260433)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.3 , pp. 951-960
    • Li, Y.-S.1    Hayakawa, K.2    Hardy, R.R.3
  • 14
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • DOI 10.1016/S1074-7613(00)80268-X
    • Li YS, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 1996;5:527-35. (Pubitemid 27062063)
    • (1996) Immunity , vol.5 , Issue.6 , pp. 527-535
    • Li, Y.-S.1    Wasserman, R.2    Hayakawa, K.3    Hardy, R.R.4
  • 15
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
    • DOI 10.1158/0008-5472.CAN-06-0160
    • Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, Gonzalez N, et al. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res. 2006;66:10995-1004. (Pubitemid 44876999)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3    Pfeiffer, T.4    Olivares, S.5    Gonzalez, N.6    Smith, D.D.7    Forman, S.J.8    Jensen, M.C.9    Cooper, L.J.N.10
  • 16
    • 33750061330 scopus 로고    scopus 로고
    • Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
    • DOI 10.1038/sj.leu.2404366, PII 2404366
    • Loskog A, Giandomenico V, Rossig C, Pule M, Dotti G, Brenner MK. Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells. Leukemia. 2006;20:1819-28. (Pubitemid 44574993)
    • (2006) Leukemia , vol.20 , Issue.10 , pp. 1819-1828
    • Loskog, A.1    Giandomenico, V.2    Rossig, C.3    Pule, M.4    Dotti, G.5    Brenner, M.K.6
  • 18
    • 84858759305 scopus 로고    scopus 로고
    • Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
    • Pegram HJ, Lee JC, Hayman EG, Imperato GH, Tedder TF, Sadelain M, et al. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012;119:4133-41.
    • (2012) Blood , vol.119 , pp. 4133-4141
    • Pegram, H.J.1    Lee, J.C.2    Hayman, E.G.3    Imperato, G.H.4    Tedder, T.F.5    Sadelain, M.6
  • 19
    • 67449108172 scopus 로고    scopus 로고
    • Eradication of established B-cell lymphoma by CD19-specific murine T cells is dependent on host lymphopenic environment and can be mediated by CD4+ and CD8+ T Cells
    • Cheadle EJ, Hawkins RE, Batha H, Rothwell DG, Ashton G, Gilham DE. Eradication of established B-cell lymphoma by CD19-specific murine T cells is dependent on host lymphopenic environment and can be mediated by CD4+ and CD8+ T Cells. J Immunother. 2009;32:207-18.
    • (2009) J Immunother , vol.32 , pp. 207-218
    • Cheadle, E.J.1    Hawkins, R.E.2    Batha, H.3    Rothwell, D.G.4    Ashton, G.5    Gilham, D.E.6
  • 20
    • 77949891071 scopus 로고    scopus 로고
    • Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells
    • Cheadle EJ, Hawkins RE, Batha H, O'Neill AL, Dovedi SJ, Gilham DE. Natural expression of the CD19 antigen impacts the long-term engraftment but not antitumor activity of CD19-specific engineered T cells. J Immunol. 2010;184:1885-96.
    • (2010) J Immunol , vol.184 , pp. 1885-1896
    • Cheadle, E.J.1    Hawkins, R.E.2    Batha, H.3    O'Neill, A.L.4    Dovedi, S.J.5    Gilham, D.E.6
  • 21
    • 84876050411 scopus 로고    scopus 로고
    • CD19 CAR-targeted T cells induce long-term remission and B cell aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia
    • Davila ML, Kloss CC, Gunset G, Sadelain M. CD19 CAR-targeted T cells induce long-term remission and B cell aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia. PLoS One. 2013;8:e61338.
    • (2013) PLoS One , vol.8
    • Davila, M.L.1    Kloss, C.C.2    Gunset, G.3    Sadelain, M.4
  • 23
    • 84875716409 scopus 로고    scopus 로고
    • High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia
    • O'Brien S, Schiller G, Lister J, Damon L, Goldberg S, Aulitzky W, et al. High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia. J Clin Oncol. 2013;31:676-83.
    • (2013) J Clin Oncol , vol.31 , pp. 676-683
    • O'Brien, S.1    Schiller, G.2    Lister, J.3    Damon, L.4    Goldberg, S.5    Aulitzky, W.6
  • 24
    • 84871491706 scopus 로고    scopus 로고
    • Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp MS, Gokbuget N, Zugmaier G, Degenhard E, Goebeler ME, Klinger M, et al. Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood. 2012;120:5185-7.
    • (2012) Blood , vol.120 , pp. 5185-5187
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3    Degenhard, E.4    Goebeler, M.E.5    Klinger, M.6
  • 25
    • 84874091597 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells directed against CD19 induce durable responses and transient cytokine release syndrome in relapsed, refractory CLL and ALL
    • Porter DL, Grupp SA, Kalos M, Loren AW, Lledo L, Gilmore J, et al. Chimeric antigen receptor T cells directed against CD19 induce durable responses and transient cytokine release syndrome in relapsed, refractory CLL and ALL. ASH Annu Meet Abstr. 2012;120:717.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 717
    • Porter, D.L.1    Grupp, S.A.2    Kalos, M.3    Loren, A.W.4    Lledo, L.5    Gilmore, J.6
  • 26
    • 84886583769 scopus 로고    scopus 로고
    • Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: Results from a phase I clinical trial of autologous CD19-targeted T cells for patients with relapsed CLL
    • Park JH, Riviere I, Wang X, Stefanski J, He Q, Taylor C, et al. Impact of the conditioning chemotherapy on outcomes in adoptive T cell therapy: results from a phase I clinical trial of autologous CD19-targeted T cells for patients with relapsed CLL. ASH Annu Meet Abstr. 2012;120:1797.
    • (2012) ASH Annu Meet Abstr , vol.120 , pp. 1797
    • Park, J.H.1    Riviere, I.2    Wang, X.3    Stefanski, J.4    He, Q.5    Taylor, C.6
  • 27
    • 77950525914 scopus 로고    scopus 로고
    • A transposon and transposase system for human application
    • Hackett PB, Largaespada DA, Cooper LJ. A transposon and transposase system for human application. Mol Ther. 2010;18:674-83.
    • (2010) Mol Ther , vol.18 , pp. 674-683
    • Hackett, P.B.1    Largaespada, D.A.2    Cooper, L.J.3
  • 29
    • 76349087378 scopus 로고    scopus 로고
    • Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication
    • Zhong XS, Matsushita M, Plotkin J, Riviere I, Sadelain M. Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8+ T cell-mediated tumor eradication. Mol Ther. 2010;18:413-20.
    • (2010) Mol Ther , vol.18 , pp. 413-420
    • Zhong, X.S.1    Matsushita, M.2    Plotkin, J.3    Riviere, I.4    Sadelain, M.5
  • 30
    • 65349157330 scopus 로고    scopus 로고
    • Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): A non-randomised phase I-II study
    • Ciceri F, Bonini C, Stanghellini MT, Bondanza A, Traversari C, Salomoni M, et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol. 2009;10:489-500.
    • (2009) Lancet Oncol , vol.10 , pp. 489-500
    • Ciceri, F.1    Bonini, C.2    Stanghellini, M.T.3    Bondanza, A.4    Traversari, C.5    Salomoni, M.6
  • 31
    • 34447310075 scopus 로고    scopus 로고
    • Inducible Caspase 9 Suicide Gene to Improve the Safety of Allodepleted T Cells after Haploidentical Stem Cell Transplantation
    • DOI 10.1016/j.bbmt.2007.04.005, PII S1083879107002509
    • Tey SK, Dotti G, Rooney CM, Heslop HE, Brenner MK. Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation. Biol Blood Marrow Transplant. 2007;13:913-24. (Pubitemid 47055386)
    • (2007) Biology of Blood and Marrow Transplantation , vol.13 , Issue.8 , pp. 913-924
    • Tey, S.-K.1    Dotti, G.2    Rooney, C.M.3    Heslop, H.E.4    Brenner, M.K.5
  • 33
    • 79955980426 scopus 로고    scopus 로고
    • In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    • Giordano Attianese GM, Marin V, Hoyos V, Savoldo B, Pizzitola I, Tettamanti S, et al. In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor. Blood. 2011;117:4736-45.
    • (2011) Blood , vol.117 , pp. 4736-4745
    • Giordano Attianese, G.M.1    Marin, V.2    Hoyos, V.3    Savoldo, B.4    Pizzitola, I.5    Tettamanti, S.6
  • 34
    • 0034125194 scopus 로고    scopus 로고
    • Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies
    • DOI 10.1038/76243
    • Trojan A, Schultze JL, Witzens M, Vonderheide RH, Ladetto M, Donovan JW, et al. Immunoglobulin framework-derived peptides function as cytotoxic T-cell epitopes commonly expressed in B-cell malignancies. Nat Med. 2000;6:667-72. (Pubitemid 30398790)
    • (2000) Nature Medicine , vol.6 , Issue.6 , pp. 667-672
    • Trojan, A.1    Schultze, J.L.2    Witzens, M.3    Vonderheide, R.H.4    Ladetto, M.5    Donovan, J.W.6    Gribben, J.G.7
  • 35
    • 33845256434 scopus 로고    scopus 로고
    • T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells
    • DOI 10.1182/blood-2006-04-017061
    • Vera J, Savoldo B, Vigouroux S, Biagi E, Pule M, Rossig C, et al. T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells. Blood. 2006;108:3890-7. (Pubitemid 44864573)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3890-3897
    • Vera, J.1    Savoldo, B.2    Vigouroux, S.3    Biagi, E.4    Pule, M.5    Rossig, C.6    Wu, J.7    Heslop, H.E.8    Rooney, C.M.9    Brenner, M.K.10    Dotti, G.11
  • 36
    • 78649461928 scopus 로고    scopus 로고
    • The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor
    • Hudecek M, Schmitt TM, Baskar S, Lupo-Stanghellini MT, Nishida T, Yamamoto TN, et al. The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood. 2010;116:4532-41.
    • (2010) Blood , vol.116 , pp. 4532-4541
    • Hudecek, M.1    Schmitt, T.M.2    Baskar, S.3    Lupo-Stanghellini, M.T.4    Nishida, T.5    Yamamoto, T.N.6
  • 40
    • 1642348370 scopus 로고    scopus 로고
    • Flow Cytometric Immunophenotypic Analysis of 306 Cases of Multiple Myeloma
    • DOI 10.1309/74R4-TB90-BUWH-27JX
    • Lin P, Owens R, Tricot G, Wilson CS. Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am J Clin Pathol. 2004;121:482-8. (Pubitemid 38392955)
    • (2004) American Journal of Clinical Pathology , vol.121 , Issue.4 , pp. 482-488
    • Lin, P.1    Owens, R.2    Tricot, G.3    Wilson, C.S.4
  • 41
    • 84856760798 scopus 로고    scopus 로고
    • T-cell immunotherapy with a chimeric receptor against CD38 is effective in eliminating myeloma cells
    • Mihara K, Bhattacharyya J, Kitanaka A, Yanagihara K, Kubo T, Takei Y, et al. T-cell immunotherapy with a chimeric receptor against CD38 is effective in eliminating myeloma cells. Leukemia. 2012;26:365-7.
    • (2012) Leukemia , vol.26 , pp. 365-367
    • Mihara, K.1    Bhattacharyya, J.2    Kitanaka, A.3    Yanagihara, K.4    Kubo, T.5    Takei, Y.6
  • 42
    • 84964256796 scopus 로고    scopus 로고
    • CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma
    • Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research
    • Benjamin R, Condomines M, Gunset G, Sadelain M. CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research. Cancer Res. 2012;72:3499.
    • (2012) Cancer Res , vol.72 , pp. 3499
    • Benjamin, R.1    Condomines, M.2    Gunset, G.3    Sadelain, M.4
  • 43
    • 77952420345 scopus 로고    scopus 로고
    • Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
    • Peinert S, Prince HM, Guru PM, Kershaw MH, Smyth MJ, Trapani JA, et al. Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther. 2010;17:678-86.
    • (2010) Gene Ther , vol.17 , pp. 678-686
    • Peinert, S.1    Prince, H.M.2    Guru, P.M.3    Kershaw, M.H.4    Smyth, M.J.5    Trapani, J.A.6
  • 44
    • 84877087137 scopus 로고    scopus 로고
    • B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma
    • Carpenter RO, Evbuomwan MO, Pittaluga S, Rose JJ, Raffeld M, Yang S, et al. B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma. Clin Cancer Res. 2013;19:2048-60.
    • (2013) Clin Cancer Res , vol.19 , pp. 2048-2060
    • Carpenter, R.O.1    Evbuomwan, M.O.2    Pittaluga, S.3    Rose, J.J.4    Raffeld, M.5    Yang, S.6
  • 45
    • 84875928576 scopus 로고    scopus 로고
    • Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma
    • Schuberth PC, Jakka G, Jensen SM, Wadle A, Gautschi F, Haley D, et al. Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma. Gene Ther. 2013;20:386-95.
    • (2013) Gene Ther , vol.20 , pp. 386-395
    • Schuberth, P.C.1    Jakka, G.2    Jensen, S.M.3    Wadle, A.4    Gautschi, F.5    Haley, D.6
  • 46
    • 78649899281 scopus 로고    scopus 로고
    • Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: Improvement of their immune activity by expression of CD33-specific chimeric receptors
    • Marin V, Pizzitola I, Agostoni V, Attianese GM, Finney H, Lawson A, et al. Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica. 2010;95:2144-52.
    • (2010) Haematologica , vol.95 , pp. 2144-2152
    • Marin, V.1    Pizzitola, I.2    Agostoni, V.3    Attianese, G.M.4    Finney, H.5    Lawson, A.6
  • 47
    • 84863019415 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor effect of anti-CD33 chimeric receptor-expressing EBV-CTL against CD33 acute myeloid leukemia
    • Dutour A, Marin V, Pizzitola I, Valsesia-Wittmann S, Lee D, Yvon E, et al. In vitro and in vivo antitumor effect of anti-CD33 chimeric receptor-expressing EBV-CTL against CD33 acute myeloid leukemia. Adv Hematol. 2012;2012:683065.
    • (2012) Adv Hematol , vol.2012 , pp. 683065
    • Dutour, A.1    Marin, V.2    Pizzitola, I.3    Valsesia-Wittmann, S.4    Lee, D.5    Yvon, E.6
  • 48
    • 84876163922 scopus 로고    scopus 로고
    • Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
    • Tettamanti S, Marin V, Pizzitola I, Magnani CF, Giordano Attianese GM, Cribioli E, et al. Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. Br J Haematol. 2013;161:389-401.
    • (2013) Br J Haematol , vol.161 , pp. 389-401
    • Tettamanti, S.1    Marin, V.2    Pizzitola, I.3    Magnani, C.F.4    Giordano Attianese, G.M.5    Cribioli, E.6
  • 49
    • 84887419384 scopus 로고    scopus 로고
    • Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia
    • Ritchie DS, Neeson PJ, Khot A, Peinert S, Tai T, Tainton K, et al. Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia. Mol Ther. 2013;21:2122-9.
    • (2013) Mol Ther , vol.21 , pp. 2122-2129
    • Ritchie, D.S.1    Neeson, P.J.2    Khot, A.3    Peinert, S.4    Tai, T.5    Tainton, K.6
  • 51
    • 84887079391 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia
    • O'Hear C, Inaba H, Pounds S, Shi L, Dahl G, Bowman WP, et al. Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia. Cancer 2013.
    • (2013) Cancer
    • O'Hear, C.1    Inaba, H.2    Pounds, S.3    Shi, L.4    Dahl, G.5    Bowman, W.P.6


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